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Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene

100%

Świercz R. , Majcherek W. , Wąsowicz W.

International Journal of Occupational Medicine and Environmental Health

2015

tom 29

nr 1

113-128

Objectives The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated. Material and Methods Male outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes. Results Significantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA. Conclusions The significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.

Effect of mesitylene on ethanol metabolism in rat liver microsomes

100%

Zajworoniuk H. , Rzeczycki W.

Acta Biochimica Polonica

1992

tom 39

nr 4

Increased catalase activity was observed in the liver microsomal fraction of ethanol-treated rats (10% v/v aqueous ethanol solution per os for 5 weeks). In contrast, cytochrome P-450 concentration and specific activity of NADPH-cytochrome c reductase remained at the same level as in the liver of control rate (drinking water). The ratio of microsomal H202-generation to catalase activity was lower In the "ethanol" group than in the control one. This phenomenon seems to be related to the increased contribution of the "peroxidatic" reaction (increased rate of ethanot oxidation). Administration of mesitylene (1,3,5-trimethylbenzene) by gastric tube for 3 days (5 mmoles per kg daily) increased cytochrome P-450 concentration» specific activity of NADPH-cytochrome c reductase and ethanol metabolism.

Mesitylene [1,3,5-trimethylbenzene] in the liver, lung, kidney, and blood and 3,5-dimethylbenzoic acid in the liver, lung, kidney and urine od rats after single and repeated inhalation exposure to mesitylene

84%

Swiercz R. , Wasowicz W. , Majcherek W.

Polish Journal of Environmental Studies

2006

tom 15

nr 3

The aim of our study was to explore the tissue distribution of 3,5-dimethylbenzene acid (3,5-DMBA) and its excretion with urine of rats and to evaluate toxicokinetics of mesitylene in blood of rats after single and repeated inhalation exposure to mesitylene vapours. Experiments were performed on male outbred IMP:WIST rats. The animals were exposed to mesitylene vapours at the target concentration of 25, 100, and 250 ppm in dynamic inhalation chambers for 6 h at single exposure and for 4 weeks (6 h/day for 5day/week) at repeated exposure. The study revealed in rats, after inhalation exposure to mesitylene, exposure-dependent increases in 3,5-DMBA tissue concentration and urinary excretion as well as enhanced mesitylene concentration in tissues and blood. After termination of exposure, mesitylene was rapidly eliminated from blood of rats. Mesitylene retention reduced in rat lungs after repeated exposure, as compared to a single exposure, was most likely the reason for its lower concentration in lungs and blood. Compared with single exposure, 3,5-DMBA concentration increased in rat lungs after repeated inhalation exposure to mesitylene at 100 and 250 ppm, and in the liver at 250 ppm, which may be associated with the induction of mesitylene-metabolizing enzymes. Mesitylene metabolism in the lungs of the rats after repeated exposure to its low concentrations probably had a significant impact on the increased urinary excretion of 3,5-DMBA.