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1
Blue nevus of the endocervix
100%
Szumilo J. , Patel A. , Patel S. , Burdan F.
Folia Morphologica
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2010
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tom 69
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nr 1
EN
The mucosa of the uterine cervix is normally devoid of melanocytes; therefore, melanin-containing lesions are very rare in this site. A new case of a common blue nevus in the cervix of a 57-year-old woman is reported. The lesion was an incidental finding in a total hysterectomy specimen performed for atypical endometrial hyperplasia. Gross and histological examination revealed minute dark macula on the mucosa of the posterior aspect of the endocervical canal, composed of loose conglomerates of spindle-shaped and dendritic cells located superficially within the stroma, containing multiple brownish granules, which exhibited positive immunostaining for HMB45 and melan A. Although the blue nevi seem to be lesions of low clinical significance, they require careful differential diagnosis with malignant melanoma, especially in scanty endocervical curettage or cervical biopsy specimens. (Folia Morphol 2010; 69, 1: 62–64)
2
Effect of alpha3beta1 and alphavbeta3 integrin glycosylation on interaction of melanoma cells with vitronectin
86%
Janik M. E. , Przybylo M. , Pochec E. , Pokrywka M. , Litynska A.
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tom 57
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nr 1
55-61
EN
 The metastatic transformation of melanocytes is associated with altered expression of adhesion molecules, including αvβ3 and α3β1 integrins. Integrin αvβ3 is a primary vitronectin (VN) receptor, while both integrin types take part in adhesion to VN when they are in complex with uPAR. Although their role in melanoma cell interaction with VN is of great interest, the influence of N-oligosaccharides attached to these glycoproteins is still unappreciated. The present study assesses the role of αvβ3 and α3β1 integrins and the influence of their glycosylation status on WM9 and WM239 metastatic melanoma cell interactions with VN. Cell adhesion to and migration on VN were selected as the studied cell behaviour parameters. Functionblocking antibodies and swainsonine (SW) treatment were used in these tests. Both cell lines interacted with VN in an integrin-mediated but cell-line-specific manner. In WM9 cells, migration was not completely inhibited by antibodies against α3β1 or αvβ3 integrins, suggesting the participation of other VN receptors. In both cell lines in coprecipitation test the formation of an integrins/uPAR complex was shown. In the presence of SW formation of the complex did not occur, suggesting the participation of glycosylation in this proccess. Additionally, the adhesion properties of WM9 cells were changed after SW treatment. Our results suggest that in these two metastatic cell lines integrin-linked N-oligosaccharides influence the VN adhesion receptor activity and function.
3
Content available Melanophores inside frogs
86%
Pshennikova E. S. , Voronina A. S.
International Letters of Natural Sciences
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2018
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tom 71
EN
Melanocytes/melanophores were known for some decades as pigment cells in skin. The origin of these cells in embryogenesis from neural crest cells is actively investigated now. Some melanocytes/melanophores were described inside adult vertebrates. Historically, these internal melanocytes have been largely ignored, until recently. In frogs, the melanophores populate not only the skin, but all the inner connective tissues: epineurium, peritoneum, mesentery, outer vascular layer and skin underside. In adult avian, melanocytes were also found in visceral connective tissues, periostea, muscles, ovaries and the peritoneum. In mammals and humans, melanocytes are also revealed in eyes, ears, heart and brain. A black-brownish pigment, which can be found in brains of humans and some mammals, was called neuromelanin. Currently, attempts are being made to treat neurodegenerative diseases and various nerve injuries with medications containing melanin. In this micro-review, we wanted to remind again about the inner melanophores on visceral organs and lining blood vessels and nerves, their importance in organisms resistance to adverse environmental factors.
4
Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features
72%
Alekseenko A. , Wojas-Pelc A. , Lis G. J. , Wisniowski Z. , Czerwinska M. , Niewiara L. , Litwin J. A.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 2
5
Content available Melanina – z melanocytu do keratynocytu, czyli jak przebiega transport melaniny w skórze
72%
Rok J. , Otręba M. , Buszman E. , Wrześniok D.
Annales Academiae Medicae Silesiensis
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2012
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tom 66
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nr 1
60-66
EN
The article presents classifi cation, functions of melanins together with maturation stages and transport mechanisms of melanosomes from melanocytes to keratinocytes. Melanins are macromolecular pigments, occuring in the plants, animals and fungi kingdoms. Melanins can be classifi ed into three groups: eumelanin, pheomelanin and allomelanin. They are widely distributed in organism and are responsible for the colour of eyes, skin, hair, feathers and coats. Protective role of melanins is connected with absorbing of UV radiation and scavenging of free radicals. They can also interact with drugs, infl uencing therapeutic and toxic eff ects. Melanins are synthesized in melanocytes, in lysosome-related organelles – melanosomes. Melanosomes mature through four morphologically distinct stages. In melanocytes, they move rapidly fi rstly along microtubules and secondly along actine fi laments to the end of dendrites. Next, melanosomes are transferred to keratinocytes, where determine colour of skin and protect against ultraviolet radiation.
PL
W artykule przedstawiono podział i funkcje melanin oraz etapy dojrzewania i transportu melanosomów z melanocytów do keratynocytów. Melaniny są wielkocząsteczkowymi barwnikami szeroko rozpowszechnionymi w przyrodzie. Można wśród nich wyróżnić eumelaninę, feomelaninę i allomelaninę. Pełnią one wiele ważnych biologicznych i biochemicznych funkcji. Odpowiadają za kolor oczu, skóry, włosów, a także sierści i piór, ponadto chronią komórki przed szkodliwym wpływem promieniowania UV i wolnych rodników. Mogą także oddziaływać z cząsteczkami leków, wpływając na ich skuteczność i toksyczność. Biosynteza melaniny zachodzi w wyspecjalizowanych komórkach barwnikowych – melanocytach. Za proces melanogenezy odpowiedzialne są melanosomy należące do grupy organelli komórkowych związanych z lizosomami. Powstają one w kilkuetapowym procesie z endosomalnych pęcherzyków, które dojrzewając przechodzą przez cztery różne stadia morfologiczne. Dojrzałe melanosomy są transportowane z obszaru okołojądrowego do wypustek dendrytycznych melanocytów kolejno za pośrednictwem mikrotubul, a następnie fi lamentów aktynowych. Zgromadzone w wypustkach melanocytarnych melanosomy są transportowane do otaczających keratynocytów, gdzie determinują zabarwienie skóry oraz pełnią funkcję ochronną przed promieniowaniem UV.
6
Content available remote Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats
58%
Gomez-SanMiguel A. B. , Nieto-Bona M. P. , Fernandez-Galaz C. , Priego T. , Martin A. I. , Lopez-Calderon A.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 2
7
Secretion of proinflammatory cytokines by normal human melanocytes in response to lipopolysaccharide
58%
Tam I. , Stepien K.
Acta Biochimica Polonica
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2011
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tom 58
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nr 4
EN
A large body of evidence suggests that epidermal melanocytes are an integral part of the skin immune system and can be considered immunocompetent cells. Recently, it has been reported that human melanocytes constitutively express Toll-like receptors and may be involved in the induction of several inflammatory cytokines. In the study the secretion of IL-1β, IL-6 and TNF-α by cultured normal melanocytes was investigated after stimulation with lipopolysaccharide. LPS increased the secretion of IL-1β in a dose-dependent manner. IL-1β stimulated release of IL-6 and TNF-α by melanocytes, whereas LPS activated production of TNF-α, but not of IL-6. These observations indicate that LPS can participate in the regulation of cytokine activity in normal human melanocytes and suggest that cytokines released by melanocytes could affect melanocytes themselves or/and other cells of the epidermis.
8
Different expression of cyclooxygenase-2 (COX-2) in selected nonmelanocytic human cutaneous lesions
58%
Kuzbicki L. , Lange D. , Stanek-Widera A. , Chwirot B. W.
Folia Histochemica et Cytobiologica
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2011
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tom 49
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nr 3
9
Content available remote Photodynamic therapy in melanoma - an update
51%
Baldea F. , Filip A. G.
Journal of Physiology and Pharmacology
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2012
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tom 63
|
nr 2
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