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CSF-1 as a regulator of macrophage activation and immune responses

100%

Sweet M. J. , Hume D. A.

Archivum Immunologiae et Therapiae Experimentalis

2003

tom 51

nr 3

Adverse effects of inhaled sand dust particles on the respiratory organs of sheep and goats exposed to severe sand storms in Mongolia

80%

Kobayashi Y. , Shimada A. , Nemoto N. , Morita T. , Adilbish A. , Bayasgalan M.-O.

nr 3

Preparation and properties of alkylphospholipid liposomes: A review

80%

Zeisig R. , Fichtner I. , Arndt D.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

Alkylphospholipids are synthetic compounds with relatively simple structures combining amphiphilic character and anticancer properties. It is possible to prepare different types of liposomes from APL if a high amount of cholesterol and a charged component is added. The biological relevant properties can be changed by sterical stabilization of these vesicles by the incorporation of up to 10 mol% poly(ethylenglycol) derivatives of phosphoethanolamine. This incorporation increased the fixed aqueous layer thickness from 0.83 nm to 3.57 nm. As a result of this changed property the uptake of such liposomes by macrophages was reduced compared to liposomes without a sterical stabilization. APL liposomes are remarkably stable in buffer and in plasma. APL-liposomes are able to induce the release of tumoricidal factors like TNF and NO from different macrophage cell lines. The strongest release was induced by a synergistic action of liposomal APC and lipopolysaccharide. Sterical stabilization prevents such an activation process likely as a result of significantly reduced uptake and internalization by the macrophages. APL are highly therapeutically active in a number of hormone-independent human mammary carcinomas. Using the MaTu mammary carcinoma xenotransplanted to nude mice the sterically stabilized HPC-SUV have the strongest cancerostatic formulation.