Wyniki wyszukiwania - Biblioteka Nauki

1

Immunotoxins, an Advance tool for Cancer Treatment: Review and update

100%

Munir I. , Naseer R. D. , Saleem M. , Mahmood A. , Sultana A.

Acta Poloniae Pharmaceutica - Drug Research

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2018

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tom 75

|

nr 6

1267-1277

EN

Conventional therapeutic approaches like chemotherapy, surgery and radiation for cancer and other malignancies have limited success rate. Several factors such as drug resistance, non-penetrability into solid tumors and unwanted toxicity due to non-specific action contribute to treatment failure. To overcome these issues, immunotoxins were developed having a target specific action. Immunotoxins are chimeric cytotoxic proteins which are formed by linking a toxin moiety to intact antibody or its fragment. Bacterial and plant based toxins are used in immunotoxins construction but they have many drawbacks in terms of immunogenicity and non-specific toxicity. Recently, a novel class of immunotoxins of human origin has been introduced. Immunotoxins fight back cancers by targeting the neoplastic cells and cause cells death by inhibiting protein synthesis. They have been categorized into two main classes, chemically conjugated immunotoxins and recombinant immunotoxins. This review summarizes recent advances in immunotoxins development and present a comprehensive illustration of sources and generations of immunotoxins. Moreover, it also highlights future directions to be explored. This review also focuses the limitations in immunotoxins development and its use.

2

Syndrome of inappropriate secretion of ADH in the course of chemotherapy for anaplastic large T-cell lymphoma of the lung

100%

Kade G. , Michalak M. , Straszyńska A. , Moczulski D. , Hałka J. , Spaleniak S.

OncoReview

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2022

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tom 12

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nr 2

50-53

EN

The present study reports the case of a 40-year-old patient who presented SIADH syndrome due to anaplastic large T-cell lymphoma and antineoplastic drugs.

3

Head and Neck Lymphomas - Diagnostic Difficulties

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Neskoromna-Jędrzejczak A. , Tyndorf M. , Arkuszewski P. , Kobos J.

Polish Journal of Surgery

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2012

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tom 84

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nr 3

113-118

EN

Malignant lymphomas represent approximately 5% of all malignant neoplasm of the head and neck and may involve nodal or extranodal sites. The head and neck region is the second most frequent anatomical site of extranodal lymphomas (after the gastrointestinal tract). Most are non-Hodgkin lymphomas (NHL) of B-cell lineage. Hodgkin's lymphoma (HL) rarely occurs in extranodal site.The aim of the study was to evaluate head and neck manifestation of lymphoma (both HL and NHL) and emphasize diagnostic difficulties of these pathologies.Material and methods. Retrospective review of medical records of patients diagnosed for lymphomas in our department was performed. Authors analyzed demographic data as well as clinical manifestation and diagnostic trials.Results. 9 patients were included to the study. 7 of them suffered from extranodal NHL and 2 of them from HL (one patient - extranodal and one nodal manifestation). There were diagnostic complications in all cases and final diagnosis was made after surgical material analysis.Conclusions. This data demonstrate low sensivity of fine needle aspiration for identification of lymphoma as well as clinical picture is non characteristic.

4

Cytotoxic effect of nitric oxide on human hematological malignant cells.

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Tsumori M. , Tanaka J. , Koshimura K. , Kawaguchi M. , Murakami Y. , Kato Y.

Acta Biochimica Polonica

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2002

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tom 49

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nr 1

139-144

EN

We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.

5

Role of biomarkers and electrocardiography assessment as individual predictors of anthracycline cardiotoxicity in lymphoma patients

88%

Długosz-Danecka M. , Jaroszyński A. , Jurczak W.

OncoReview

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2018

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tom 8

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nr 4

99-104

EN

The significant progress in the treatment of non-Hodgkin lymphomas, translating into prolongation of overall survival results in the manifestation of long-term adverse events, like anthracycline-related cardiotoxicity. Despite the dose-dependent cardiac dysfunction and the presence of risk factors, the increasing probability of cardiotoxicity arises from individual predisposition. Identification of high- -risk patients gives the opportunity to implement the prevention strategies to reduce the incidence of cardiac complications. The study evaluated the utility of biomarkers: N-terminal B-type natriuretic peptide, troponin I and electrocardiography with spatial QRS-T angle assessment, as indicators of individual sensitivity of cardiomyocytes to doxorubicin resulting in myocardial damage. Thirty-five treatment-naïve patients at increased risk of cardiotoxicity, were subjected prospectively during (R)-CHOP treatment to echocardiographic assessment and analysis of biomarkers: TnI and NT-proBNP plasma level and spatial QRS-T assessment before and 24 hours after each cycle of chemotherapy. The analysis of QRS-T angle was consistent with the results of NT-proBNP assessment and allowed to identify, after the first cycle of chemotherapy, patients at increased risk of developing cardiovascular complications, who require thorough echocardiographic analysis and primary cardioprotection implementation. Our data did not reveal the role of TnI in the identification of cardiac events. Our findings, though promising, should be confirmed in a larger group of patients in real-life or clinical trials.

6

Follicular mucinosis on the forehead of a 15-year-old girl

88%

Brzeziński P. , Chiriac A.

OncoReview

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2015

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tom 5

|

nr 3

A122-124

EN

Follicular mucinosis is a rare dermatosis characterized by accumulation of mucin in the follicular epithelium and sebaceous glands. Clinically, it is characterized by the presence of papules or well-circumscribed and infiltrative plaques. In this paper, we report a case of a 15-year-old girl, in which an asymptomatic, erythematous and infiltrative plaque evolved within a few weeks in the forehead region. There was no regression of the lesion with the use of topical glucocorticosteroids and isotretinoinum for 30 days.

7

Quality of life patients treated with rituximab intravenous versus subcutaneous in B-cell lymphomas: results from outpatient Hematooncology Clinic in Lodz

88%

Witkowska M. , Witkowska S. , Klimczak M. , Frydecka A. , Witkowski M. , Smolewski P.

OncoReview

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2021

|

tom 11

|

nr 2

33-39

EN

Introduction: Nowadays, rituximab is available both as intravenous (IV) and subcutaneous (SC) formulations. The aim of this study is to compare quality of life (QOL) of patients treated in Hematooncology Clinic in Lodz with B-cell nonHodgkin lymphoma (B-NHL) treated with rituximab IV and SC. Material and Methods: In 50 adult patients with B-NHL diagnosis we assessed QOL by three different questionnaries (EORTC QLQ-C30, FACT/ GOG-NTx and EQ-5D). We compared it between patients treated with rituximab IV and SC. Results: In comparison of general condition in EQ-5D-3L and EORTC QLQ-C30 questionnaire patients treated with rituximab SC felt statistically better than with IV administration (p<0.01). In SC group general health was evaluated for 72 while in IV for only 58,1. According to FACT/GOG-NTx questionnaire SC group had significantly better physical well-being. In SC group we observed statistically more complete responses (CR) 21 (88%) versus 17 (65%) in IV group. Moreover, trend was observed in emotional well-being in favor of SC treatment. Discussion: In our study we observed for the first time in the literature statistical difference in frequency of vomiting, nausea, and lack of appetite mentioned from our patients in questionnarie. It is very important that this findings were not published in any other study comparing SC and IV route od administration. Also looking at economic side of SC administration, this type of dosing. As a result it should be preferred form for B-cell lymphoma patients.

8

Molecular hematology – modern methodology serving patients and research

88%

Witt M.

Nauka

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2009

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nr 4

PL

The article describes a country-wide attempt to organize a network of laboratories performing molecular diagnostic procedures in a context of clinical hematology. The principles of construction of a commissioned grant in molecular hematology are presented. A major result of this project, the monographic book on molecular hematology is being announced.

9

Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules.

88%

Łuczyński W. , Stasiak-Barmuta A. , Krawczuk-Rybak M. , Szymański M. , Malinowska I. , Mitura-Lesiuk M.

Acta Biochimica Polonica

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2004

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tom 51

|

nr 4

1067-1073

EN

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.

10

The role of residence near hazardous waste sites containing benzene in the development of hematologic cancers in upstate New York

88%

Boberg E. , Lessner L. , Carpenter D. O.

International Journal of Occupational Medicine and Environmental Health

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2011

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tom 24

|

nr 4

327-338

EN

Objectives: Epidemiologic studies suggest an association between environmental exposure to benzene and hematologic cancers, but the relationship is not fi rmly established. The aim of this study was to assess the potential association between residence near hazardous waste sites containing benzene and hospitalization discharge rates for persons having hematologic cancers. Materials and Methods: We determined the number of hospital discharges of people with hematologic cancers in New York State except for New York City for the years 1993 to 2008. Descriptive statistics and negative binomial regression models were used to compare the rates of hospitalization of residents in zip codes containing hazardous waste sites containing benzene to the rates of discharges from residents in zip codes without waste sites. Results: When adjusting for potential confounders we found a 15% increase in the rate of hospitalization for chronic lymphatic leukemia (CLL) [rate ratio (RR): 1.15; 95% confi dence interval (CI): 1.00–1.33], a 22% increase in the rate of discharges for total leukemia (RR: 1.22; 95% CI: 1.04–1.43) and a 17% increase in the rate of discharges for total lymphoma (RR: 1.17; 95% CI: 1.02–1.35) in the benzene exposed sites. We found greater effects of exposure in African Americans compared to Caucasians, females compared to males and people with higher socioeconomic status (SES) compared to those with lower SES for several of the diseases studied. Conclusions: After controlling for major confounders we found statistically signifi cant increases in discharge rates for several hematologic cancers in persons residing in zip codes containing benzene waste sites. These results provide additional support for a relationship between environmental exposure to benzene and risk of hematologic cancers.

11

Prognostic role of clinical presentation, cytological picture and response to treatment in canine centroblastic lymphoma

75%

Kliczkowska-Klarowicz K. , Jagielski D. , Czopowicz M. , Sapierzyński R. , Kliczkowska-Klarowicz K. , Jagielski D. , Czopowicz M. , Sapierzyński R.

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12

Outcomes of Jehovah’s Witnesses with hematological malignancies treated without transfusions — single center experience

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Drozd-Sokołowska J. E. , Waszczuk-Gajda A. , Dwilewicz-Trojaczek J. , Walesiak A. , Krzyżanowska M. , Paluszewska M. , Wieczorek J. , Wiktor-Jędrzejczak W. , Drozd-Sokołowska J. E. , Waszczuk-Gajda A. , Dwilewicz-Trojaczek J. , Walesiak A. , Krzyżanowska M. , Paluszewska M. , Wieczorek J. , Wiktor-Jędrzejczak W.

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tom 60

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nr 4

13

Immunohistochemical assessment of metalloproteinases MMP2 and MMP9 expression in canine various subtypes of lymphomas in relation with proliferative and apoptotic markers

75%

Sokołowska J. , Urbańska K. , Sokołowska J. , Urbańska K.

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14

Chłoniak złośliwy czy choroba Kikuchi-Fujimoto – opis przypadku

75%

Syrek-Kaplita K. , Karczmarek-Borowska B. , Sałek A. , Fudali L.

Medical Review

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2013

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nr 2

257–263

PL

Pacjentka lat 70, została skierowana do Ośrodka Onkologicznego z podejrzeniem chłoniaka złośliwego. Po wykonaniu badań i ponownej ocenie preparatów histopatologicznych rozpoznano chorobę Kikuchi- Fujimoto. Następnie chora została przekazana pod opiekę Poradni Reumatologicznej. Choroba Kikuchi- Fujimoto znana jako histiocytarne, martwicze zapalenie węzłów chłonnych bez nacieków granulocytarnych jest limfadenopatią o nieznanej etiologii. Po raz pierwszy została opisana w 1972 roku w Japonii, przez niezależnych badaczy Kikuchi i Fujimoto. Podczas diagnostyki pod uwagę bierze się choroby infekcyjne, autoimmunologiczne, nowotworowe- głównie rozrosty układu chłonnego lub przerzuty guzów litych. Podstawą rozpoznania jest potwierdzenie cech klinicznych oraz histopatologicznych. W terapii stosuje się leczenie objawowe, ale w większości przypadków zmiany ulegają samoistnej regresji.

EN

The case is a 70-year-old female patient, who was directed to the Oncology Center with suspected malignant lymphoma. The evaluation and histopathological reexamination suggested Kikuchi-Fujimoto disease. The patient was then referred to a Rheumatology Clinic. The Kikuchi-Fujimoto disease or histiocytic, necrotizing lymphadenitis without granulocytic infiltration is a lymphadenopathy of unknown etiology. It was first described in Japan by independent researchers Kikuchi and Fujimoto in 1972. During the diagnostic workup infectious, autoimmune, or neoplastic diseases are taken into consideration. The diagnosis is confirmed both by clinical and histopathological features of the disease. Symptomatic treatment is administered, but the changes regress spontaneously in most cases.

15

Lymphadenomegaly in dogs - cytological study

75%

Sapierzynski R. , Micun J.

Polish Journal of Veterinary Sciences

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2009

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tom 12

|

nr 2

263-268

EN

Lymphadenomegaly is the enlargement of the lymph node/nodes, due to various nonneoplastic or neoplastic processes, observed mainly in dogs, rarely in other animal species. The first step of a diagnostic procedure in cases of lymph nodes enlargement, apart from physical examination and morphological blood analysis, should be a cytological examination of an enlarged lymph node/nodes. The aim of the present study was to determine the character and the cause of the lymph node/nodes enlargement in dogs and to evaluate the usefulness of fine-needle cytology in a diagnosis of lymphadenomegaly. The study was performed on dogs submitted to consultation in the Small Animal Clinic of Department of Clinical Sciences, Warsaw University of Life Sciences, due to generalized or local lymphadenomegaly, and in which fine-needle biopsy was made. A signalement, general state of dog, the presence and duration of clinical signs, the character (generalized vs. localized) and intensity (mild, moderate or severe) of lympadenomegaly were recorded during physical examination. The average age of dogs examined was 8 years, 64 were males and 36 were females of various breeds; however the majority of them were greater than 25 kg in weight. The cytological diagnosis including most often lymphoma and reactive hyperplasia, more seldom metastatic neoplasm and lymphadenitis were recognized, some of the samples were considered nondiagnostic/nondefined. On the basis of the present results it can be concluded that cytological examination of good quality samples allows to obtain final diagnosis in over 90% of lymphadenomegaly. Higher incidence of canine lymphomas in males is suggested.

16

DNA repair in drug resistance induced by fusion tyrosine kinases

75%

Blasiak J.

Cellular and Molecular Biology Letters

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2002

|

tom 07

|

nr Suppl.

17

Immunocytochemical and cytomorphometric diagnostics of malignant lymphomas in dogs

75%

Dzimira S.

Bulletin of the Veterinary Institute in Puławy

|

2007

|

tom 51

|

nr 1

EN

Monoclonal antibodies are used to determine whether tumour cells of malignant lymphomas in dogs belong to B or T lymphocytes, to define the proliferative potential of the cells (Ki-67 protein, PCNA antigen, AgNORs) and to demonstrate effects of potential mutations of the p53 gene. Among 76 examined cases, 58 tumours (76.32%) were lymphomas of lymphocytes B; the remaining 18 (23.68%) cases were qualified as originating from lymphocytes T. Lymphomas with a high grade of malignancy prevailed (54 cases, 71.06%), and also in this group of lymphomas of lymphocytes B prevailed (48 cases, 88.89%). The remaining 22 cases (28.95%) represented less malignant lymphomas, including 12 cases of lymphocyte T lymphomas (54.54%). In the group of highly malignant lymphomas, high values of Ki- 67 and PCNA indices were demonstrated. Positive reactions of low intensity with anti-p53 protein were obtained in 31 cases (57.4%) of highly malignant and in 9 cases (40.9%) of less malignant lymphomas. In dogs, most frequently malignant centroblastic B receptor lymphomas are encountered. The extent of malignancy is determined by young forms and their proliferation exponents are Ki-67 and PCNA proteins.

18

Association of EBV infection with lymphomas

75%

Trzcinska A. , Litwinska B.

Acta Microbiologica Polonica

|

2003

|

tom 52

|

nr 2

19

Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules

75%

Luczynski W. , Stasiak-Barmuta A. , Krawczuk-Rybak M. , Szymanski M. , Malinowska I. , Mitura-Lesiuk M.

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 4

EN

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.

20

Usefulness od real-time PCR in long-term follow-up of follicular lymphoma patients

75%

Tysarowski A. , Fabisiewicz A. , Paszkiewicz-Kozik E. , Kulik J. , Walewski J. , Siedlecki J. A.

Acta Biochimica Polonica

|

2007

|

tom 54

|

nr 1

EN

The aim of this study was to evaluate the usefulness of quantitative real-time PCR (RQ-PCR) for the monitoring of molecular remission in follicular lymphoma (FL) patients during long-term follow-up. RQ-PCR by the use of TaqMan® detection system is a sensitive tool to monitor minimal residual disease (MRD) in FL through amplification of the t(14;18) fusion gene during and post-therapy. In most cases the breakpoint region occurs within the major breakpoint region (MBR). Among 75 patients diagnosed with FL, cells harboring the fusion gene BCL2/JH were found in peripheral blood of 31 patients (41%). We further monitored 30 of these patients in a period varying from 6 months to 5 years by RQ-PCR. In our study the level indicating the possibility of the presence of MRD was established at more than five t(14;18)-positive cells in the background of 83000 normal cells. The results of this work also confirmed that the presence of MRD detected by RQ-PCR is an indication for careful observation of patients because of a higher risk of disease recurrence.