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The influence of luteolin on expression of epithelial MUC1 mucin in human skin fibroblasts

100%

Wosek J. , Radziejewska I. , Andrulewicz E.

Progress in Health Sciences

2016

tom 6(2)

64-69

Purpose: The membrane-anchored MUC1 mucin is typically expressed on normal and cancerous epithelial cells. Non-epithelial localization of this mucin is rare. However, the presence of MUC1 in human skin fibroblasts has been recently unexpectedly revealed. The aim of the study was to prove the expression of MUC1 mucin in human skin fibroblasts and the examine of the influence of luteolin on its expression. Materials and methods: ELISA tests and real-time PCR analysis were used to assess the expression of MUC1 mucin in fibroblast cells cocultured with 30 μM concentration of luteolin. Results: The expression of MUC1 was revealed in human skin fibroblasts. Luteolin decreased the relative level of mucin in cell lysates and media. Statistically significant decreased expression of MUC1 gene after luteolin treatment of fibroblasts cells was also revealed. Conclusion: Our results prove non-epithelial localization of MUC1 mucin. Luteolin inhibits the expression of MUC1 mucin in healthy human skin fibroblasts.

Potentiometric and spectrophotometric determination of the stability constants of luteolin (3',4',5,7-tetrahydroxyflavone) complexes with aluminium(III) and iron(III)

63%

Karadag R.

Chemia Analityczna

2003

tom Vol. 48, No. 6

931-937

In this study, one determined stability constants of the complexes of luteolin with aluminium (III) and iron(lll). Potentiometric methods of Calvin-Bjerrum and Irving-Rossotti, and spec-trophotometric assay have been utilised. The evaluated protonation constants of the ligand were: logk(1) = 8.95, logk(2) = 8.10, and logk(3) = 6.85 at the 25°C. For the aluminium and iron complexes the subsequent logarithms of formation constants were found: for Al 17.50, 15.00, 4.75 and for iron: 19.60, 19.40, 17.82.

Spektrofotometrycznie i potencjometrycznie stosując metody Calvina-Bjerruma i Irvinga-Rossottiego, wyznaczono stale wartości kompleksów luteoliny z glinem(III) i żelazem(III). Wyznaczone stałe protonowania ligandu wynosiły log k(2) = 8,95; log k2 = 8,10; log k(3) = 6,85 w temperaturze 25°C. Dla kompleksów glinu kolejne wartości logarytmów stałych tworzenia wynosiły: 17,50; 15,00; 4,75, zaś dla kompleksów żelaza: 19,60; 19,40; 17,82.

Transport of 3 - bromopyruvate across the human erythrocyte membrane

63%

Sadowska-Bartosz I. , Soszynski M. , Ulaszewski S. , Ko Y. , Bartosz G.

Cellular and Molecular Biology Letters

2014

tom 19

nr 2

3-Bromopyruvic acid (3-BP) is a promising anticancer compound because it is a strong inhibitor of glycolytic enzymes, especially glyceraldehyde 3-phosphate dehydrogenase. The Warburg effect means that malignant cells are much more dependent on glycolysis than normal cells. Potential complications of anticancer therapy with 3-BP are side effects due to its interaction with normal cells, especially erythrocytes. Transport into cells is critical for 3-BP to have intracellular effects. The aim of our study was the kinetic characterization of 3-BP transport into human erythrocytes. 3-BP uptake by erythrocytes was linear within the first 3 min and pH-dependent. The transport rate decreased with increasing pH in the range of 6.0–8.0. The Km and Vm values for 3-BP transport were 0.89 mM and 0.94 mmol/(l cells x min), respectively. The transport was inhibited competitively by pyruvate and significantly inhibited by DIDS, SITS, and 1-cyano-4-hydroxycinnamic acid. Flavonoids also inhibited 3-BP transport: the most potent inhibition was found for luteolin and quercetin.

Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge

63%

Manju V. , Balasubramaniyan V. , Nalini N.

Cellular and Molecular Biology Letters

2005

tom 10

nr 3

Gold nanoparticles phytoreduced with Cornus mas extract mitigate some of gliadin effects on Caco-2 cells

51%

Domsa E. M. , Filip G. A. , Olteanu D. , Baldea I. , Glichici S. , Muresan A. , David L. , Moldovan B. , Para I. , Suciu M. , Achim M. , Negrean V. , Andreica V.

Journal of Physiology and Pharmacology

2020

tom 71

nr 2