Wyniki wyszukiwania - Biblioteka Nauki

1

Influence of the Classic and Laparoscopic Bariatric Operations For the Ventilation Lung Activity

100%

Świαtkowska M. , Cywiński J. , Hedayati M. , Drozda R. , Wieloch M. , Kołomecki K.

Polish Journal of Surgery

|

2008

|

tom 80

|

nr 12

659-663

EN

The obese patient constitute the group with high perioperative risk due to more respiratory and cardiovascular disorders. The respiratory disorders deepen during postoperative period.The aim of the study was an assessment of changes in ventilation lung activity after classic and laparoscopic bariatric operations.Material and methods. For the lung activity assessment the measurement of pick expiratory flow was used before operation, in the first and third twenty-four hours after operation. Moreover, before and in the first twenty-four hours after operation a spirometry was performed. The forced vital capacity (FVC), 1 second forced expiratory volume (FEV1) and Tiffenau index (FEV1/FVC) were estimated in the study. 54 persons were included in batriatric operations. The first group was formed by the patients after vertical banded gastroplasty (VBG), the second after laparoscopic vertical banded gastroplasty (LVBG), the third one after laparoscopic adjustable gastric banding (LABG).Results. The following average results were gained: first group-PEF before operation 399 liter per minute, in the first twenty-four hours after operation 195 liter per minute and in the third twenty-four hours 282 liter per minute. FEV1 before operation 2.6 liter, in the first twenty-four hours 1.5 liter, FVC before 3.5 liter and after operation 2liter. Tiffenau index before 86%, after 85%. The second group PEF before operation 446 liter per minute, in the first twenty-four hours 326 liter per minute in the third twenty-four hours 409 liter per minute, FEV1 before 3.6 liter, after 2.6 liter, FVC before 3.9 liter, after 2.7 liter, Tiffenau index before 92%, after 96%. The third group PEF before 460 liter per minute, in the first twenty-four hours 340 liter per minute, in the third twenty-four hours 430 liter per minute, FEV1 before 3.2 liter, after 3.1 liter, FVC before 4.5 liter, after 3.6 liter, Tiffenau index before 90%, after 90%.Conclusions. The bariatric operations reduce ventilation lung activity. After classic bariatric surgery respiratory disorders are longer and become more intense. Independently of bariatric operation's method all respiratory disorders have a restrict type.

2

Comparative study of lung function changes in farmers and industrial workers

100%

Mustajbegovic J. , Zuskin E. , Kern J. , Doko-Jelinic J.

Annals of Agricultural and Environmental Medicine

|

1994

|

tom 01

|

nr 2

3

Anthropometric variables and PEFR

88%

Chandel R. , Shivhare G. , Bhagat A.

Central European Journal of Sport Sciences and Medicine

|

2022

|

tom 39

|

nr 03

4

Lung function - clinical importance, problems, and new results

88%

Ulmer W. T.

Journal of Physiology and Pharmacology. Supplement

|

2003

|

tom 54

|

nr 1

11-13

EN

This review tackles the usefulness of spirometry, a more than century old method of assessing pulmonary lung function. Variables measured with a spirometer, such as forced expiratory volume in 1 s, have long been the mainstays of the diagnosis and treatment of lung disorders. But there are problems with the reliability of spirometric measurements. The method depends on the cooperation of the investigated subject, which introduces a confounding subjective element and all too often results in test failure, and the results are evaluated against the predicted values that are based on a set of fixed factors, some of which, such as body height, are not in a straight proportion to the intrathoracic gas volume. Substantial spread of results arises, which makes a reliable assessment of lung function difficult. New methods, such as the resistance-volume curve, provide better information on airway behavior in different conditions. These new methods, which basically evolved from spirometry, show that the old idea of lung function analysis is still viable and may remain helpful for diagnosis and treatment of respiratory pathological states.

5

Wheezing and lung function measured in subjects exposed to various levels of fine particles and polycyclic aromatic hydrocarbons

88%

Jedrychowski W. , Perera F. , Whyatt R. , Mroz E. , Flak E. , Jacek R. , Penar A. , Spengler J. , Camman D.

Open Medicine

|

2007

|

tom 2

|

nr 1

66-78

EN

The main purpose of the study was to assess the occurrence of wheezing and lung function in non-smoking women exposed to various levels of fine particulate matter(FP) and polycyclic aromatic hydrocarbons (PAH). Out of the total study group, 152 women were included in the lower exposed group (PM2.5 ≤34.3μg/m3 or PAHs ≤ 22.9ng/ m3) and 96 persons in higher concentrations of both air pollutants (PM2.5>34.3μg/m3 and PAHs > 22.9ng/ m3). Except for FVC and FEV1, all lung forced ventilatory flows (PEFR, FEF25% FEF50%, FEF75%, FEF25−75%) were significantly lower in the higher exposed group. The findings suggest bronchoconstriction within the respiratory tract, which may be related to the exposure under study. This was consistent with a higher prevalence of wheezing in more exposed subjects. It was shown that higher levels of both pollutants increased the risk of wheezing by factor 5.6 (95% CI: 1.77–17.8) after accounting for potential confounders such as allergic diseases and exposure to ETS. This study suggests that pollutants in question may have the capacity to promote broncho-constriction and asthmatic symptoms, possibly by bronchial inflammation resulting from the exposure.

6

Toxocariasis and lung function: Relevance of a neglected infection in an urban landscape

75%

Walsh M. G. , Haseeb M. A.

Acta Parasitologica

|

2014

|

tom 59

|

nr 1

EN

Toxocariasis has been highlighted as a potentially important neglected infection of poverty in developed countries that experience substantive health disparities such as the United States. An association between Toxocara infection and lung function, in concert with a relatively high prevalence of infection, may mark an important mechanism by which this infection could contribute significantly to the differential morbidity across different socioeconomic groups and landscapes. To assess the potential relevance of this infection in a dense urban environment, we measured the association between forced expiratory volume in 1 second (FEV1) and serology diagnosed Toxocara infection in a sample of US-born New York City residents. We identified a significant independent association between Toxocara infection and lung function, wherein those with previous Toxocara infection had a 236.9 mL reduced FEV1 compared to those without Toxocara infection even after adjusting for age, sex, ethnicity, level of education, smoking status, body mass index, and pet ownership. These findings from New York City corroborate similar findings in a national sample and, while the cross-sectional data preclude a direct causal relationship, this study identifies a potentially important neglected infection in a dense urban landscape.

7

Comparison of the effects of low-dose vs. high-dose aminophylline on lung function in experimental meconium aspiration syndrome

75%

Mokra D. , Drgova A. , Mokry J. , Pullmann R. , Redfors B. , Petraskova M. , Calkovska A.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

449-459

8

Increased risk of horse sensitization in southwestern Iranian horse riders

75%

Moghtaderi M. , Farjadian S. , Hosseini Z. , Raayat A.

International Journal of Occupational Medicine and Environmental Health

|

2015

|

tom 28

|

nr 5

909-913

EN

Objectives The aim of this study has been to investigate the frequency of sensitization to horse allergens and clinical symptoms in horse riders. Material and Methods A total of 42 horse riders and 50 healthy individuals were examined by means of skin prick tests for a panel of horse and common animal allergens, and pulmonary function tests were done by spirometry. Results The rate of sensitization to horse allergens was 31% as proven by the skin prick test in horse riders whereas horse sensitization was not seen in the control group. Occupational allergy symptoms were reported by 19 horse riders. Two horse riders with no history of clinical symptoms showed positive skin reactions to horse allergens. Conclusions To decrease the high risk of occupational sensitization among horse riders, workplace conditions should be improved to reduce the load of airborne horse allergens.

9

Endotoxin exposure and changes in short-term pulmonary function among sewage workers

75%

Cyprowski M. , Sobala W. , Buczyńska A. , Szadkowska-Stańczyk I.

International Journal of Occupational Medicine and Environmental Health

|

2015

|

tom 28

|

nr 5

803-811

EN

Objectives The inhaled endotoxin is considered as a causative factor in the process of acute bronchial obstruction, which can be measured by a decrease in forced expiratory volume in 1 s (FEV₁). The aim of this study was to assess endotoxin exposure among sewage treatment plant workers (STPW) and its effect on across-shift changes in respiratory airflow. Material and Methods A group of 78 STPW from a large sewage treatment plant was studied. Inhalable dust for endotoxin assessment was collected using personal aerosol samplers. Endotoxin was assayed with the kinetic, chromogenic Limulus amebocyte lysate test. Across-shift spirometric measurements were performed on Mondays, after 2-days absence from work, with the use of portable spirometer. The forced vital capacity (FVC), and FEV₁ parameters were analyzed. Multifactor regression modeling was performed to determine parameters significantly associated with endotoxin exposure. Results The concentration of inhalable dust and endotoxin ranged from 0.01–1.38 mg/m³ and 0.68–214 endotoxin units per cubic meter of air (EU/m³), respectively. Endotoxins were characterized with the skewed distribution (arithmetic mean (AM) = 38.8 EU/m³, geometric mean (GM) = 15.4 EU/m³, geometric standard deviation (GSD) = 4.21). Through the use of multifactor analysis, which excluded the main confounders (inhalable dust and smoking habit) it was found that, despite low levels of endotoxin, it had significant impact on the observed across-shift decline in FEV₁ (p = 0.044). For this parameter, the regression slope was additionally calculated (r = –0.017, p = 0.071). Conclusions Relatively low levels of endotoxin among sewage treatment plant workers may cause small, but significant across-shift declines in FEV₁. The observed relationship was independent of organic dust concentrations and smoking habit. The respiratory protection should be provided for STPW.

10

New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine

75%

Van Overveld F. J. , Demkow U. , Gorecka D. , De Backer W. A. , Zielinski J.

Journal of Physiology and Pharmacology. Supplement

|

2005

|

tom 56

|

nr 4

135-142

EN

Inhaled corticosteroids (ICS) are widely used for the treatment of COPD despite of controversial statements concerning their efficacy. The use of N-acetylcysteine (NAC), a mucolytic drug with antioxidant properties, is less clear, but it may counteract the oxidant-antioxidant imbalance in COPD. The aim of this study was to evaluate whether treatment of COPD patients with ICS or NAC is able to improve inflammatory indices and to enhance lung function. ICS treatment enhanced protective markers for oxidative stress such as glutathione peroxidase (GPx) (51.2 ±5.8 vs. 62.2 ±8.6 U/g Hb, P<0.02) and trolox-equivalent antioxidant capacity (TEAC) (1.44 ±0.05 vs. 1.52 ±0.06 mM, P<0.05). NAC decreased sputum eosinophil cationic protein (318 ±73 vs. 163 ±30 ng/ml, P<0.01) and sputum IL-8 (429 ±80 vs. 347 ±70 ng/ml, P<0.05). The increased antioxidant capacity prevented an up-regulation of adhesion molecules, since the levels of intracellular adhesion molecule 1 (ICAM-1) correlated negatively with GPx (P<0.0001) and TEAC (P<0.0001). On the other hand, expression of adhesion molecules was promoted by inflammation, reflected by a positive correlation between the levels of IL-8 and ICAM-1 (P<0.0001). The effects of treatment on lung function were only reflected in the FEV1 values. The absolute value of FEV1, both before and after salbutamol inhalation, increased from 1690 ±98 to 1764 ±110 ml, and 1818 ±106 to 1906 ±116 ml, respectively, after ICS (P<0.05) . Ten weeks after treatment, FEV1 values dropped to 1716 ±120 ml post-salbutamol (P<0.05). When followed by treatment with NAC, these values decreased even further to 1666 ±84 ml. These results suggest that ICS improved lung function in COPD patients with moderate airflow obstruction, beside a minor improvement in the oxidant-antioxidant imbalance leading to a lesser expression of ICAM-1. Treatment with NAC decreased some inflammatory parameters and had indirectly an inhibitory effect on the expression of adhesion molecules.

11

Relationship between nutritional status and pulmonary function in adult cystic fibrosis patients

75%

Gozdzik J. , Cofta S. , Piorunek T. , Batura-Gabryel H. , Kosicki J.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

253-260

12

Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis

75%

Chorostowska-Wynimko J. , Lesniewska-Radomska D. , Krychniak-Soszka A. , Remiszewski P. , Szopinski J. , Wesolowski S. , Kus J. , Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

|

2004

|

tom 55

|

nr 3

41-47

EN

Sarcoidosis is a chronic inflammatory multiorgan disease of unknown origin. Our previous study demonstrated a significant correlation between the relative count of nonCD4+, nonCD8+ lymphocytes in bronchoalveolar lavage of active sarcoidosis patients and proangiogenic activity of BAL homogenates. The aim of the present study was to evaluate in a group of 40 patients with active sarcoidosis the possible relationship between the intensity of alveolitis, particularly the nonCD4+, nonCD8+ lymphocyte subset, and other parameters characterizing the level of pulmonary (lung function tests) and extrapulmonary (spleen longitudinal dimension) disease activity. We found that the relative count of nonCD4+, nonCD8+ lymphocytes in BAL correlated positively with spleen size (r=0.50, P<0.01) and negatively with static compliance (r=0.43, P<0.05). We concluded that the lymphocytes belonging to the nonCD4+nonCD8+ subset participate in the inflammatory process in sarcoidosis. However, more detailed phenotypic and functional characteristics of this cellular population are needed.

13

Pulmonary function between 40 and 80 years of age

75%

Ostrowski S. , Grzywa-Celinska A. , Mieczkowska J. , Rychlik M. , Lachowska-Kotowska P. , Lopatynski J.

Journal of Physiology and Pharmacology. Supplement

|

2005

|

tom 56

|

nr 4

127-133

EN

Spirometry is the most frequently performed lung function test. To determine a normal range of spirometry results, reference formulas are used. Predicted values play an important role in establishing whether the volumes measured in an individual fall within a range to be expected in a healthy person of the same gender, height, and age. Such standards enable to assess the development of the respiratory system in the youth, the early recognition of the influence of a disease on the respiratory system and the influence of environmental factors on lung function. The objective of the present study was to estimate lung function prediction equations and to identify appropriate normal reference values for the Lublin Region local population of adults. We addressed the issue by analyzing the data from a lung function screening program conducted in the Lublin Region of Poland. Pulmonary function of adults aged 40-80 years was assessed from the measurements of forced vital capacity (FVC) and forced expired volume in the first second (FEV1) in 136 adults. Reference values of FVC and FEV1 for females and males were calculated by linear multiple regressions with age and height used as predictors. Different equations were compared to show their reliability when applied to the local population. The results were as follows. In females, the mean FEV1 was 2.856 ±0.534 (L) (113.7 ±14.3%) and the mean FVC was 3.517 ±0.662 (L) (118.5 ±14.1%), in males, 3.913 ±0.773 (L) (110.9 ±15.1%), 4.922 ±0.941 (L) (112.1 ±14.1%), respectively. The estimated prediction equations were: for the FVC - for females - FVC (L) = 0.0528 (height) - 0.0262 (age) - 3.676 and for males - FVC = 0.0756 (height) - 0.0649 (age) - 4.904; and for the FEV1 - for females - FEV1 (L) = 0.0378 (height) - 0.0282 (age) - 1.799 and for males - FEV1 (L) = 0.0553 (height) - 0.0553 (age) - 2.874. Units are years for age and centimeters for height. In conclusion, the analysis of the lung function data showed that there were significant difficulties in determining the appropriate reference values of FEV1 and FVC. The predicted FEV1 and FVC values derived from equations based on the ECSC (1) reference populations are considerably lower than those calculated in the present study, re-emphasizing the need to be cautious when applying the ECSC reference values for the local Lublin population. There seems to be a need for a constant refinement of spirometric standards.

14

New insights into physiology and pathophysiology by resistance-volume recordings

75%

Ulmer W. T. , Schafer T.

Journal of Physiology and Pharmacology. Supplement

|

2004

|

tom 55

|

nr 3

149-153

EN

This work deals with the assessment of airway resistance in the course of a single breath. The study showed the presence of an early increase in the resistance at the beginning of expiration, which intensifies during expiration and ends up with a sharp decline during expiring the last remaining volume of ca 350 ml. The dynamic changes in airway resistance over a breath depend on the disharmonic interplay between diaphragm function and bronchial wall tonus. Thus, airway resistance is not constant during breathing, as could be misleadingly judged from the total resistance averaged over a breath. The study underscores the importance of recording the resistance-volume curves alongside the standard flow-volume curves to be able to discern the peculiarities of airway resistance changes during a single breath. Knowing changes in the instantaneous airway resistance characteristic for a given lung pathology could appreciably improve the diagnostic and therapeutic powers.

15

Lung function in a five-year follow-up study of farmers

75%

Iversen M. , Brink O. , Dahl R.

Annals of Agricultural and Environmental Medicine

|

1994

|

tom 01

|

nr 1

16

Relationship between respiratory symptoms and annual rate of change in pulmonary function in grain elevator workers

75%

Senthilselvan A. , Pahwa P. , Wang P. Z. , McDuffie H. M. , Dosman J. A.

Annals of Agricultural and Environmental Medicine

|

1994

|

tom 01

|

nr 2

17

Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury

63%

Kosutova P. , Mikolka P. , Balentova S. , Kolomaznik M. , Adamkov M. , Mokry J. , Calkovska A. , Mokra D.

Journal of Physiology and Pharmacology

|

2018

|

tom 69

|

nr 5

18

Modulatory effect of sera from patients with various types of pulmonary fibrosis on mononuclear cell-induced angiogenesis in relation to pulmonary function

63%

Zielonka T. M. , Demkow U. , Filewska M. , Bialas-Chromiec B. , Zycinska K. , Szopinski J. , Remiszewski P. , Rowinska-Zakrzewska E. , Wardyn K. A. , Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

771-779

19

Late consequences of respiratory system burns

63%

Krzywiecki A. , Ziora D. , Niepsuj G. , Jastrzebski D. , Dworniczak S. , Kozielski J.

Journal of Physiology and Pharmacology. Supplement

|

2007

|

tom 58

|

nr 5

20

How accurate is spirometry at predicting restrictive pulmonary impairment in children with myasthenia gravis

63%

Zielonka T. , Kostera-Pruszczyk A. , Ryniewicz B. , Korczynski P. , Szyluk B.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 4

409-416

EN

Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction. Clinical symptoms are caused by weakness and increased fatigability of various muscle groups. Myasthenia may lead to significant respiratory dysfunction. The aim of our study was to estimate lung function in children with MG. We tested 23 non-smoking patients (18 girls and 5 boys) aged 7-18 years. Whole-body plethysmography and spirometry were performed in all patients. In 33% of the patients a decrease in VC <80% of predicted value was observed (VC = 89 ±19%), but the analysis of TLC revealed restrictive pattern only in one patient (TLC = 102 ±17%). In more than 75% of the children the value of RV above 120% of predicted value was found (RV = 146 ±54%). Spirometric obstructive pattern measured by FEV1%VC <70% was not observed, although in 56% of the patients airway resistance was increased (Raw = 132 ±44%). In 45% of the patients a decrease of PEF (76 ±14%) was observed. In MG children true restrictive pulmonary impairment is rarely observed and a decrease in VC in these patents seems to result mainly from functional restriction provoked by an increase in RV. Spirometry is not an optimum method to assess functional changes in MG patients. The assessment of additional measures such as TLC, RV, and Raw is desirable.