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EN
Recent decades have witnessed the ageing of populations in many countries across the world accompanied by unprecedented social, cultural, and technological change as well as recognition of the implications of climate change. As this demographic transformation has posed a full range of challenges to policy dimensions in certain countries, the importance of older people being able to access appropriate learning opportunities has become more widely recognised. Increasingly, it is understood that this is necessary not only for the economies of different countries, which may require people to remain for longer in the labour market but also as an essential component of a fulfilling later life. However, a focus only on chronological age and ageing fails to allow for the more positive aspects of what may be termed “the longevity effect” which has been driven by a better understanding of the factors that influence increased life expectancy in different countries, enabling people to live longer, happier and more productive lives. It is argued firstly that we need to rethink the current focus on “aging” and replace it with a more positive emphasis on “longevity” that includes an understanding of what happens to our brains as we grow older. Secondly, the concept of “long life learning” which is beginning to appear in different contexts is explored. Thirdly, it is acknowledged that the worldwide spread of COVID-19 has both opened up some novel ways of helping some older people to learn and, simultaneously, widened the so-called digital divide. Finally, the pernicious influence of ageism is considered.
EN
Objectives: The aim of this review was to explain the literature about the association between physical activity and longevity. Methods: The search was carried out in all databases of Web of Science and in all years (1900-2020), until December 31, 2020. The search term was “physical activity longevity” and the search was restricted to title. The inclusion criteria for papers were: 1. Type: Original papers. 2. Language: English. 3. Sample: Human participants. 4. Measures: Longevity and physical activity. Findings: A total of 52 papers were found. After applying the inclusion and exclusion criteria, only 15 papers of these 52 papers were included in this review. The 15 studies found that physical activity have a positive impact on longevity. Conclusions: Physical activity can extend longevity and delay mortality. Future studies should focus on explaining the influence of different types of physical activities on longevity and identifying potential mechanisms. Public health strategies should be implemented to increase the physical activity levels of the population.
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EN
The success of experimental biology was possible due to the use of model organisms. It is believed that the mechanisms of aging have a universal character and they are conserved in a wide range of organisms. The explanation of these universal mechanisms by tracing survival curves of model organisms clearly suggests that death of individuals is a direct consequence of aging. Furthermore, the use of unicellular organisms like yeast Saccharomyces cerevisiae to explain the aging processes of multicellular organisms runs the risk of oversimplification. Aging is a very complex process and therefore in this paper we present arguments suggesting that some of these fundamental assumptions require a deep rethinking and verification.
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Content available On the Depictions and Intricacies of Senility
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PL
Starszy człowiek niejako na naszych oczach stał się przedstawicielem jednej z najliczniejszych grup ludności współczesnego świata. Rozpatrując w związku ztym zjawiskiem zagadnienie starości, oscyluje się przeważnie pomiędzy dwoma poglądami. Jeden z nich głosi, że starość jest cechą typowo ludzką, która pojawia się w niezbyt odległym od nas okresie dzięki poprawie warunków życia oraz postępowi wiedzy. Drugi zakłada, że żyjący wcześniej starsi ludzie nie pojawiali się jako odrębna kategoria społeczna, ponieważ utożsamiało się ich z ogółem dorosłych. Niezależnie od tego, jaką wersję przyjmiemy, okres, który nazywamy starością, jest obecnie powszechnie dostępną dla większości osób częścią życia człowieka. Okresem, który zwykle nas nie zadowala, choć jest równie istotny i cenny jak dzieciństwo, okres dojrzewania lub młodości. Celem niniejszego artykułu przeglądowego jest próba zachęcenia czytelnika do zainteresowania się zagadnieniem wieku sędziwego poprzez przedstawienie zarysu losów oraz obrazów starości w kontekście wybranych społeczeństw.
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Content available remote Resilience as a Factor of Longevity and Gender Differences in Its Effects
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EN
Various explanations for longevity and mortality differences have been repeatedly tested and discussed in the context of worldwide population ageing. This study contributes to this field of research by testing the potential of resilience as a capacity to adapt in the face of adversity through individual and social resources and is the first European study to investigate how resilience predicts survival in later life. Panel data from the Survey of Health, Ageing and Retirement in Europe are used to determine the predictors of survival among people over the age of 75 between waves 1, 2, 4, and 5. The results of a multilevel logistic regression show that resilience is a strong predictor of survival among the oldest old and that this is true even when controlling for the amount and severity of adversity. Resilience is found on its own to be a stronger predictor of survival in women, while the amount and severity of adversity is more important in men. Resilience is therefore found to be an important factor in longevity and survival in later life and the stronger effect of resilience in women can partly explain the ‘gender paradox’. To sum up, resilience is observed to be protective against decease, especially through the use of social resources, which are stronger among women and which are not measured in most traditionally used resilience scales.
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Content available Poczucie jakości życia osób długowiecznych
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The changing demography and the progress in medicine, pharmacy, undertaking preventive actions, allow a wider group of people reach the age of aging, and even a longevity. Unparalleled in the human history number of people will reach and exceed the ninetieth and hundredth year of life. Therefore the main aim of this study was to determine the level of the sense of the quality of life for generations of 90+ and comparing it with the sense of the quality of life for people in earlier stages of aging (75–89, 60–74). The sense of the quality of life was defined as a multidimensional occurence, including four main spheres of man’s functioning: psychophisical, psychosocial, subjective and metaphisical (spiritual).
EN
The yeast Saccharomyces cerevisiae has long been used as a model organism for studying the basic mechanisms of aging. However, the main problem with the use of this unicellular fungus is the unit of "longevity". For all organisms, lifespan is expressed in units of time, while in the case of yeast it is defined by the number of daughter cells produced. Additionally, in yeast the phenotypic effects of mutations often show a clear dependence on the genetic background, suggesting the need for an analysis of strains representing different genetic backgrounds. Our results confirm the data presented in earlier papers that the reproductive potential is strongly associated with an increase in cell volume per generation. An excessive cell volume results in the loss of reproductive capacity. These data clearly support the hypertrophy hypothesis. The time of life of all analysed mutants, with the exception of sch9D, is the same as in the case of the wild-type strain. Interestingly, the 121% increase of the fob1D mutant's reproductive potential compared to the sfp1D mutant does not result in prolongation of the mutant's time of life (total lifespan).
EN
The yeast Saccharomyces cerevisiae has a finite replicative life span. Yeasts possess two prohibitins, Phb1p and Phb2p, in similarity to mammalian cells. These proteins are located in the inner mitochondrial membrane, where they are involved in the processing of newly-synthesized membrane proteins. We demonstrate that the elimination of one or both of the prohibitin genes in yeast markedly diminished the replicative life span of cells that lack fully-functional mitochondria, while having no effect on cells with functioning mitochondria. This deleterious effect was suppressed by the deletion of the RAS2 gene. The expression of PHB1 and PHB2 declined gradually up to 5-fold during the life span. Cells in which PHB1 was deleted in conjunction with the absence of a mitochondrial genome displayed remarkable changes in mitochondrial morphology, distribution, and inheritance. This loss of mitochondrial integrity was not seen in cells devoid of PHB1 but possessing an intact mitochondrial genome. In a subset of the cells, the changes in mitochondrial integrity were associated with increased production of reactive oxygen species, which co-localized with the altered mitochondria. The mitochondrial deficits described above were all suppressed by deletion of RAS2. Our data, together with published information, are interpreted to provide a unified view of the role of the prohibitins in yeast aging. This model posits that the key initiating event is a decline in mitochondrial function, which leads to progressive oxidative damage that is exacerbated in the absence of the prohibitins. This aggravation of the initial damage is ameliorated by the suppression of the production of mitochondrial proteins in the absence of Ras2p signaling of mitochondrial biogenesis.
EN
This study was carried out to determine the effects of packaging materials and storage periods on seed quality and longevity dynamics of an endangered tropical tree species, Pericopsis elata. The experimental period was December, 2015 to June, 2016. Seed collection was done at the Bobiri Forest Reserve. The seed storage experiment was set up using 3 x 6 factorial arrangements in Completely Randomized Design with three replications. Six packaging materials (jute, nylon, paper, ziplock bag, airtight bottle and no packaging) and three storage periods (no storage, three months storage and six months storage) were used. Germination percentage, seed vigour, 1000 seed weight, moisture content, carbohydrate, protein and oil contents were assessed before storage, three months and six months after storage. P. elata seeds with initial moisture content of 7.5% and packaged in airtight bottle and ziplock bags maintained their moisture contents even as storage periods increased. The initial amounts of seed carbohydrates (1.9%), proteins (37.4%) and oil (31.3%) were maintained in the airtight packaging materials (bottle and ziplock bag) thereby improving seed storability. The seed viability equation predicted that P. elata seeds could be stored for 243 years after six months of storage. Seed viability dropped to 164 days after the accelerated aging test was performed on the six-months old stored seeds. The study concluded that the seeds of this important endangered tree can be stored in airtight containers before the next planting season without any loss in seed quality.
EN
Since aging is primarily the result of a failure of maintenance and repair mechanisms, various approaches are being developed in order to stimulate these pathways and modulate the process of aging. One such approach, termed hormesis, involves challenging cells and organisms by mild stress that often results in anti-aging and life prolonging effects. In a series of experimental studies, we have reported that repeated mild heat stress (RMHS) has anti-aging hormetic effects on growth and various cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. These beneficial effects of repeated challenge include the maintenance of stress protein profile, reduction in the accumulation of oxidatively and glycoxidatively damaged proteins, stimulation of the proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to other stresses, and enhanced levels of cellular antioxidant ability. In order to elucidate the molecular mechanisms of hormetic effects of RMHS, we are now undertaking studies on signal transduction pathways, energy production and utilisation kinetics, and the proteomic analysis of patterns of proteins synthesised and their posttranslational modifications in various types of human cells undergoing cellular aging in vitro. Human applications of hormesis include early intervention and modulation of the aging process to prevent or delay the onset of age-related conditions, such as sarcopenia, Alzheimer's disease, Parkinson's disease, cataracts and osteoporosis.
EN
Aging is currently stimulating intense interest of both researchers and the general public. In developed countries, the average life expectancy has increased by roughly 30 years within the last century, and human senescence has been delayed by around a decade. Although aging is arguably the most familiar aspect of human biology, its proximate and ultimate causes have not been elucidated fully and understood yet. Nowadays there are two main approaches to the ultimate causes of aging. These are deterministic and stochastic models. The proximate theories constitute a distinct group of explanations. They focus on mechanistic causes of aging. In this view, there is no reason to believe that there is only one biological mechanism responsible for aging. The aging process is highly complex and results from an accumulation of random molecular damage. Currently, the disposable soma theory (DST), proposed by Thomas Kirkwood, is the most influential and coherent line of reasoning in biogerontology. This model does not postulate any particular mechanism underpinning somatic defense. Therefore, it is compatible with various models, including mechanistic and evolutionary explanations. Recently, however, an interesting theory of hyper-function of mTOR as a more direct cause of aging has been formulated by Mikhail Blagosklonny, offering an entirely different approach to numerous problems and paradoxes in current biogerontology. In this view, aging is quasi-programmed, which means that it is an aimless continuation of developmental growth. This mTOR-centric model allows the prediction of completely new relationships. The aim of this article is to present and compare the views of both parties in the dispute, based on the results of some recent experimental studies, and the contemporary knowledge of selected major aspects of human aging and longevity
PL
W oparciu o metodę autorską badania kinetyki zużywania materiałów przy tarciu ślizgowym przedstawiono metodę oszacowania trwałości zużyciowej przekładni ślimakowych ze ślimakiem Archimedesa. Ustalono postać funkcji zużycia liniowego zębów ślimacznicy w wybranych punktach przyporu. Na podstawie rozwiązania numerycznego określono charakter zależności resursu przekładni od zużycia.
EN
On the basis of the author’s investigation, a method of material kinetics wear in sliding friction using the developed method of value wear longevity of worm gears with Archimedean worm are presented. The type of the function of worm teeth linear wear in select points of gears has been established. On the basis of a numerical solution, the character of dependence of resource gear from wear has been defined.
EN
The purpose of this paper is twofold. First we consider a ruin theory approach along with risk measures in order to determine the solvency capital of long-term guarantees such as life insurances or pension products. Secondly, for such products,we challenge the definition of the Solvency Capital Requirement (SCR) under the Solvency II (SII) regulatory framework based on a yearly viewpoint. Several methods for the calculation of the solvency capital are presented. We start our study with risk measures as considered in the SII framework and then proceed with the ruin theory approach. Instead of considering the continuous time setting of the ruin theory,we consider the discrete time-the yearly basis-of the accounting viewpoint.We finally give an illustration with a fixed guaranteed rate product along with the equity, interest rate and longevity risks. The latter risk brings us to consider zero-coupon longevity bonds in which we invest the capital. We show that long-term guarantees might be overloaded under the SII regulation.
EN
According to demographers, percentage of seniors who have a chance to live for a hundred years still increases. These predictions force us to the reflection about raising the quality of aging by promoting a model of successful aging. Experts in this area are certainly the oldest citizens who with their life prove that living in old age can be satisfying. The article presents studies conducted among centenarians. The research concerned the phenomenonof longevity. The life-extending factors were also analyzed. The frame for theoretical assumptions are statements of centenarians on the principles of successful aging. A case study method based on press sources was applied.
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