Wyniki wyszukiwania - Biblioteka Nauki

1

Visualization of pathologic changes in liver tissue via polarized light

100%

Stoilova A. , Blagoeva B. , Nazarova D. , Stoykova E. , Berberova-Buhova N. , Nedelchev L. , Machikhin A.

Optica Applicata

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2022

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tom Vol. 52, nr 3

395--404

EN

In this work, we applied two polarized light based approaches to visualize histological patterns of liver pathologies. The first one involves acquisition of two images through a polarizing microscope, one image (Ppar) acquired with the analyzer oriented parallel to the polarization of illumination and the other (Pper) acquired with the analyzer oriented perpendicular to the illumination. The final image is based on the polarization ratio, Preconstructed = (Ppar – Pper)/(Ppar + Pper). Using the second technique, the histological specimens were illuminated with a polarized laser beam with wavelength of 635 nm. Polarimetric parameters as azimuth, angle of ellipticity, degree of polarization and reflected power have been measured to quantify the change in the polarization state of the incident light after interaction with the sample of the healthy tissue and of the tissue with abnormal morphological changes.

2

Lack of salidroside impact on selected cytochromes encoding genes transcription in the liver of ethanol induced rats

75%

Kujawski R. , Szulc M. , Tobola M. , Graczyk M. , Czora-Poczwardowska K. , Baraniak J. , Kania-Dobrowolska M. , Slynko-Krzyzostaniak J. , Krajewska-Patan A. , Mikolajczak P. L.

Herba Polonica

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2021

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tom 67

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nr 3

3

Determination of coumarin-3-carboxylic acid in the liver and heart tissue of Sprague-Dawley rats after intragastric administration of extractive of leaves of F. virens var. sublanceolata by HPLC

75%

Xiang Y. , Chuahe B. , Zhang J. , Li J. , Jiang X.

Acta Chromatographica

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2024

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tom Vol. 36, no. 1

1--6

EN

The study was aimed to validate and optimize high performance liquid chromatographic (HPLC) method for the determination of coumarin-3-carboxylic acid (C3A) in the heart and liver issue of Sprague-Dawley (SD) rats after intragastric administration of extractive of leaves of Ficus virens var sublanceolata. And simple ADME and target prediction analyses were performed for C3A. Ethyl acetate was employed to precipitate protein with appropriate sensitivity and acceptable matrix effects. The satisfactory separation was developed on an ODS2 column (4.6 mm × 250 mm, 5 μm) by gradient elution with a methanol-acetic acid solution (pH = 3.0) as the mobile phase. The flow rate was 1.0 mL min⁻¹, the column temperature was maintained at 30 ± 2 °C, the injection volume was 20 μL, and the detection wavelength was set as 309 nm. The method was fully validated in terms of selectivity, linearity, accuracy, precision, extraction recovery and stability. The results of the ADME analysis found that C3A has excellent characteristics of drug-likeness, consistent with good bio-absorption. And the predicted 12 target protein belongs to the amine oxidoreductase and carbonic anhydrase target class. This method is simple, rapid, sensitive, and accurate for the determination of coumarin-3-carboxylic acid in the heart and liver tissue of SD rats.

4

The amount of liver tissue is essential for accurate histological staging in patients with autoimmune hepatitis

63%

Vetter M. , Kremer A. E. , Agaimy A. , Konturek P. C. , Pfeifer L. , Neurath M. F. , Siebler J. , Zopf S.

Journal of Physiology and Pharmacology

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2021

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tom 72

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nr 1

5

The concentration of ethanol affects its penetration rate in bovine cardiac and hepatic tissues

63%

Dunster-Jones M. , Steicke M. , Mackie J. , Guthrie R. , Dinh T. N. , Ahmady F. , Golledge J. , Wang Y.

Folia Histochemica et Cytobiologica

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2018

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tom 56

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nr 2

6

T1 and T2 NMR relaxation times in cattle liver tissue during Fasciola hepatica invasion

63%

Grabiec S. , Guttowa A. , Wranicz M.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1988

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tom 36

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nr 4-6

7

Persistent organic pollutant content in cod [Gadus morhua L.] from the Barents Sea Region

63%

Sapota G. , Wisniewska-Wojtasik B.

Oceanological and Hydrobiological Studies

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2007

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tom 36

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nr 3

8

Relationship between biomarker responses and contaminant concentration in selected tissues of flounder (Platichthys flesus) from the Polish coastal area of the Baltic Sea

51%

Napierska D. , Podolska M.

Oceanologia

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2008

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tom 50

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nr 3

421-442

EN

Previous studies in the Gulf of Gdańsk discussed the responses of selected enzymatic biomarkers to the contaminant gradient in fish and mussels. In the present study, flounder muscle and liver tissues were analyzed for polychlorinated biphenyls (PCB congeners: 28, 52, 101, 118, 138, 153 and 180), organochlorine pesticides (HCHs, HCB and DDTs), and trace metals (Pb, Cd, Zn, Cu, Hg, Cr). An attempt was made to identify the relationship between the measured enzymatic biomarker responses (cholinesterases, malic enzyme, isocitrate dehydrogenase, glutathione S-transferase) and contaminant concentrations in selected flounder tissues. The observed differences in enzymatic biomarker levels suggest that chronic exposure to low-concentration mixtures of contaminants may be occurring in the studied area. However, no conclusive evidence was found of a clear link between the biomarker responses and contaminant concentrations in flounder tissues.