Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 6

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: liposomal drug

Sortuj według:

Ogranicz wyniki do:

Molecular interactions and dynamics in liposome-drug systems revealed by EPR spectroscopy

100%

Grof P.

Cellular and Molecular Biology Letters

2005

tom 10

nr Suppl.

Sphingomyelin-cholesterol liposomes. Effect of natural resorcinolic amphiphiles on their properties

84%

Przeworska E. , Kamps J. A. A. M. , Scherphof G. L. , Kozubek A.

Cellular and Molecular Biology Letters

1999

tom 04

nr 2

From nanotechnology to nanomedicine: our liposome experience

84%

Barenholz Y.

Cellular and Molecular Biology Letters

2005

tom 10

nr Suppl.

In vitro antibacterial activity of liposomal polymyxin B incorporated into collagen sponge

84%

Trafny E. A. , Antos-Bielska M. , Grzybowski J.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

The new antibacterial collagen dressing implant was constructed. The dressing was composed of collagen sponge saturated with liposomal polymyxin B (Lip-PolB). As a control an alternative dressing composed of collagen sponge saturated with free polymyxin B (Free-PolB) was used. The release of the antibiotic from the Lip-PolB was measured by diffusion of the drug into polyurethane sponge saturated with sterile broth employing “polyurethane sponge model” published previously. The antibiotic was released from Lip-PolB four times slower than from Free-PolB. Antibacterial activity of the dressing was tested using also polyurethane sponge model, with polyurethane sponge saturated with the bacterial broth culture of P. aeruginosa (108 CFU/ml). After 1, 2 and 3 days of incubation at 37°C, polyurethane sponges were sonicated in the tubes with PBS; then the CFU number was examined by plating. The Lip-PolB proved again to be several times less effective than Free-PolB. We can draw a conclusion that collagen sponge with liposomal polymyxin B can serve as an effective reservoir of the drug for control of infection in superficial wounds. However, the concentration of liposomal drug applied topically should be several times higher than the concentration of free drug.

Liposomal drug delivery, a novel approach: PLARosomes

84%

Kozubek A. , Gubernator J. , Przeworska E. , Stasiuk M.

Acta Biochimica Polonica

2000

tom 47

nr 3

Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.

Pharmacokinetics, biodistribution and bioavailability of liposomal drugs

84%

Allen T. M. , Charrois G. , Laginha K.

Cellular and Molecular Biology Letters

2005

tom 10

nr Suppl.