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EN
The characteristics of T lymphocytes’ subpopulations (helper, cytotoxic, regulatory, memory and others) have been described. Among T helper cells one can enumerate Th0, Th1, Th2, Th9, Th17, Th22, TFH and nTh2, while among T cytotoxic cells: Tc and NKT, Tγδ, T CD8αα (IEL). Among regulatory cells there are nTreg, iTreg, TR1, iTR35, together with lymphocytes T with CD8, such as CD8+CD122+, CD8+CD28, CD11c+CD8+, while among memory T cells there are Tcm and Tem. Moreover there are some so called “others” T cells, such as Tn (T αβ CD4+ i T αβ CD8+), T exhausted and T anergic.
EN
The role of T regulatory cells (Tregs) in transplantology has been widely studied over the years. The mouse model of skin transplantation is used as a quick and easy way to monitor the immune response of Tregs, vital for creation and maintenance of homeostasis and immunological tolerance. This model is extremely useful in the assessment of allograft rejection and immune tolerance induction dependent on Tregs. The procedure of skin transplantation is widely used not only in transplantology, but also in studies on the effectiveness of various immunosuppressive compounds and studies on autoimmune diseases, including diabetes, multiple sclerosis and albinism. The improved protocol of mouse tail skin grafting is easy to master, and its wide application gives many opportunities for new solutions in biomedical research.
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