Wyniki wyszukiwania - Biblioteka Nauki

1

Inhibition of Selected Enzymes with Specific Inhibitors in the Tissue Homogenates from Patients with Colorectal Cancer

100%

Hap A. , Kielan W. , Siewiński M. , Tarnawa R. , Agrawal A. , Rudno-Rudzińska J. , Hap W. , Grzebieniak Z.

|

2010

|

tom 82

|

nr 9

504-509

EN

Large intestine malignancy is the second most common malignancy and second leading cause of cancer mortality in Poland. This is related to late detection of these lesions, e.g. due to lack of effective screening tests. Lesions found by a surgeon are clinically advanced, making the treatment often ineffective and sometimes even completely impossible. Discovery of a substance that would be able to stop key processes for the development of malignancy could change such situation. Activity of certain enzymes was found to increase in malignant cells and invasion of malignancy could be triggered by inadequate amount of endogenous inhibitors of these enzymes in the surrounding healthy tissues. Inhibitors identical with that produced in human cells were found in egg whites.The aim of the study was to determine ability of cystatin isolated from egg whites to inhibit activity of cathepsin B and L.Material and methods. Immunohistochemistry and histology of tissue specimen collected from malignant lesions resected from 60 patients diagnosed with large intestine adenocarcinoma, who underwent surgical treatment in 2nd Department of General and Oncological Surgery, Medical University of Wrocław between 2007 and 2009.Results. Differences were fund between health tissues, margins and center of the malignant lesions with regard to amount and distribution of stained cathepsin B - cystatin complexes. The above mentioned inhibitors were able to inhibit 90% of primary activity of cathepsin B and L in malignant tissues.Conclusions. Cystatins obtained from egg whites could be used as substances supporting anti-cancer therapy in the future.

2

A new species of Spauligodon (Nematoda; Oxyuroidea; Pharyngodonidae) and other nematodes in Cyrtodactylus epiroticus (Squamata; Gekkonidae) from Papua, New Guinea

72%

Bursey C. R. , Goldberg S. R. , Kraus F.

Acta Parasitologica

|

2017

|

tom 62

|

nr 4

3

New species of Parapharyngodon (Nematoda: Pharyngodonidae) in Phymaturus spp. (Iguania: Liolaemidae) from Argentina

72%

Ramallo G. , Bursey C. , Castillo G. , Acosta J. C.

|

nr 3

4

Histopathological changes in small and large intestines during hymenolepidosis in rats

72%

Kosik-Bogacka D. I. , Kolasa A.

Folia Biologica

|

2012

|

tom 60

|

nr 3-4

5

Diagnostyka ultrasonograficzna chorób jelit u dorosłych

72%

Smereczyński A. , Kołaczyk K.

|

2015

|

tom 11

|

nr 2

157-165

EN

Ultrasonography is the first step in the diagnosis of acute and chronic diseases of the abdominal cavity by imaging methods. In an increasing number of cases ultrasound examination is used to diagnose lesions located in the intestines, which beside the mesenteries and the omentum are an important part of the abdomen. The aim of this overview paper is to present the current possibilities of ultrasonography in the assessment of pathologies of the gastrointestinal tract. Currently it is possible to present the anatomy of the intestinal wall, vascular network and the surrounding tissue with a great precision, even through transabdominal access. It is facilitated by digital sonograms, especially using harmonic imaging, spatial and XRES imaging as well as variable transducer pressure. Even better results can be obtained using endoscopic ultrasound, which can be equipped with a Doppler blood flow imaging facility and elastography. In addition, endoscopic ultrasound can be used to guide the collection of material for cytology or pathomorphology examination and the performance of various medical procedures. Over the recent years the diagnostic value of ultrasound increased following the introduction of intestinal hydrosonography and ultrasound contrast media, which also work very well in fistulography. Therefore, it is not surprising that ultrasonography used by an experienced practitioner makes it possible to diagnose the vast majority of intestinal pathologies and their complications as well as the results of the treatment applied. This is especially applicable to infectious, inflammatory, ischaemic and various neoplastic diseases. In the case of neoplastic lesions the stage of local advancement of the process can be determined, especially using endosonography. In a transabdominal examination this method achieves high efficacy in the diagnosis of acute appendicitis and in diverticulitis of the large intestine, which is decisive for the selection of the method of treatment. Its value was also demonstrated in bowel obstruction and in less frequently occurring lesions such as epiploic appendagitis or greater omental infarction. Ultrasonography has little importance in the diagnosis of gastrointestinal tract bleeding in patients with a substantial amount of gas in the digestive tract, obese patients and uncooperative ones.

PL

Ultrasonografia stanowi pierwszy krok w diagnostyce obrazowej ostrych i przewlekłych chorób jamy brzusznej. Coraz częściej dotyczy to zmian położonych w jelitach, które wspólnie z krezkami i siecią są istotną składową brzucha. Celem tego opracowania przeglądowego jest zaprezentowanie aktualnych możliwości ultrasonografii w ocenie patologii przewodu pokarmowego. Obecnie można z dużą dokładnością przedstawić budowę ściany jelit, ich unaczynienie oraz otaczającą tkankę nawet z dostępu przezbrzusznego. Ułatwiają to ucyfrowione sonogramy, szczególnie z użyciem obrazowania harmonicznego, złożonego przestrzennie i techniką XRES oraz dozowanego ucisku głowicą. Jeszcze lepsze wyniki uzyskuje się dzięki ultrasonografii endoskopowej, która może być wyposażona w dopplerowskie wersje odwzorowania przepływu krwi oraz w elastografię. Ponadto pod jej kontrolą można pobrać materiał do badania cytologicznego lub patomorfologicznego oraz wykonać różne procedury zabiegowe. W ostatnich latach wartość diagnostyczna ultrasonografii wzrosła po wprowadzeniu hydrosonografii jelit oraz ultrasonograficznych środków kontrastujących, które doskonale przydają się też przy fistulografii. Nie może więc dziwić fakt, że ultrasonografia w doświadczonych rękach pozwala rozpoznać zdecydowaną większość patologii jelit, ich powikłań oraz skutków zastosowanej terapii. Dotyczy to przede wszystkim: chorób infekcyjnych, zapalnych, niedokrwiennych oraz różnego rodzaju nowotworów jelit. W przypadku zmian nowotworowych można z dużą dokładnością określić stopień miejscowego zaawansowania procesu, zwłaszcza dzięki endosonografii. W badaniu przezbrzusznym metoda ta uzyskuje wysokie wskaźniki diagnostyczne w ostrym zapaleniu wyrostka robaczkowego oraz w zapaleniu uchyłków jelita grubego, co decyduje o wyborze metody leczniczej. Ponadto wykazano jej wartość w niedrożności jelit i w rzadziej występujących zmianach, takich jak zapalenie przyczepków sieciowych oraz zawał sieci większej. Ultrasonografia ma niewielkie znaczenie w diagnostyce krwawienia z przewodu pokarmowego u pacjentów zagazowanych, otyłych i niewspółpracujących.

6

A new species of Cosmocerca (Nematoda, Cosmocercidae) and other helminths from Barygenys atra (Anura, Microhylidae) from Papua New Guinea

72%

Bursey C. R. , Goldberg S. R. , Kraus F.

Acta Parasitologica

|

2013

|

tom 58

|

nr 1

EN

Cosmocerca oroensis sp. nov. (Ascaridida, Cosmocercidae) from the large intestine of Barygenys atra (Anura, Microhylidae) is described and illustrated. Cosmocerca oroensis represents the 26th species assigned to the genus and the 7th from the Australo-Papuan biogeographical region. Cosmocerca oroensis sp. nov. differs from the previously described Australo-Papuan species in number of plectanes: C. oroensis with 2 pairs; C. australis, 3–4 pairs; C. archeyi, C. tyleri and C. zugi, 4 pairs; C. limnodynastes and C. novaeguineae, 5 pairs. In addition to the new nematode species, Meteterakis crombiei (Nematoda, Heterakidae) was also found.

7

Cosmocercoides himalayanus sp. nov. (Nematoda, Cosmocercidae) in Duttaphrynus himalayanus (Amphibia, Anura) from Dehradun (Uttarakhand), India

72%

Rizvi A. N. , Bursey C. R.

Acta Parasitologica

|

2014

|

tom 59

|

nr 1

EN

Cosmocercoides himalayanus sp. nov. (Nematoda, Cosmocercidae) from the large intestine of Duttaphrynus himalayanus (Amphibia, Anura) from Dehradun, India is described and illustrated. Cosmocercoides himalayanus sp. nov. represents the 21st species assigned to the genus and the 9th species from the Oriental biogeographical region. Cosmocercoides himalayanus sp. nov. differs from the previously described Oriental species in number and position of rosette papillae; it is the only species possessing 24 or more rosette papillae to have 4 postcloacal papillae. In addition, a list of species assigned to Cosmocercoides is provided; however, C. fotedari Arya, 1992 is removed from the genus and until further study is considered a species inquirenda.

8

Organisation of autonomic nervous structures in the large intestine of chinchilla (Chinchilla laniger Molina)

72%

Nowak E.

|

nr 3-4

9

Diagnostyka ultrasonograficzna chorób jelit u dorosłych

72%

Smereczyński A. , Kołaczyk K.

|

nr 1

78-86

EN

Ultrasonography is the first step in the diagnosis of acute and chronic diseases of the abdominal cavity by imaging methods. In an increasing number of cases ultrasound examination is used to diagnose lesions located in the intestines, which beside the mesenteries and the omentum are an important part of the abdomen. The aim of this overview paper is to present the current possibilities of ultrasonography in the assessment of pathologies of the gastrointestinal tract. Currently it is possible to present the anatomy of the intestinal wall, vascular network and the surrounding tissue with a great precision, even through transabdominal access. It is facilitated by digital sonograms, especially using harmonic imaging, spatial and XRES imaging as well as variable transducer pressure. Even better results can be obtained using endoscopic ultrasound, which can be equipped with a Doppler blood flow imaging facility and elastography. In addition, endoscopic ultrasound can be used to guide the collection of material for cytology or pathomorphology examination and the performance of various medical procedures. Over the recent years the diagnostic value of ultrasound increased following the introduction of intestinal hydrosonography and ultrasound contrast media, which also work very well in fistulography. Therefore, it is not surprising that ultrasonography used by an experienced practitioner makes it possible to diagnose the vast majority of intestinal pathologies and their complications as well as the results of the treatment applied. This is especially applicable to infectious, inflammatory, ischaemic and various neoplastic diseases. In the case of neoplastic lesions the stage of local advancement of the process can be determined, especially using endosonography. In a transabdominal examination this method achieves high efficacy in the diagnosis of acute appendicitis and in diverticulitis of the large intestine, which is decisive for the selection of the method of treatment. Its value was also demonstrated in bowel obstruction and in less frequently occurring lesions such as epiploic appendagitis or greater omental infarction. Ultrasonography has little importance in the diagnosis of gastrointestinal tract bleeding in patients with a substantial amount of gas in the digestive tract, obese patients and uncooperative ones.

PL

Ultrasonografia stanowi pierwszy krok w diagnostyce obrazowej ostrych i przewlekłych chorób jamy brzusznej. Coraz częściej dotyczy to zmian położonych w jelitach, które wspólnie z krezkami i siecią są istotną składową brzucha. Celem tego opracowania przeglądowego jest zaprezentowanie aktualnych możliwości ultrasonografii w ocenie patologii przewodu pokarmowego. Obecnie można z dużą dokładnością przedstawić budowę ściany jelit, ich unaczynienie oraz otaczającą tkankę nawet z dostępu przezbrzusznego. Ułatwiają to ucyfrowione sonogramy, szczególnie z użyciem obrazowania harmonicznego, złożonego przestrzennie i techniką XRES oraz dozowanego ucisku głowicą. Jeszcze lepsze wyniki uzyskuje się dzięki ultrasonografii endoskopowej, która może być wyposażona w dopplerowskie wersje odwzorowania przepływu krwi oraz w elastografię. Ponadto pod jej kontrolą można pobrać materiał do badania cytologicznego lub patomorfologicznego oraz wykonać różne procedury zabiegowe. W ostatnich latach wartość diagnostyczna ultrasonografii wzrosła po wprowadzeniu hydrosonografii jelit oraz ultrasonograficznych środków kontrastujących, które doskonale przydają się też przy fistulografii. Nie może więc dziwić fakt, że ultrasonografia w doświadczonych rękach pozwala rozpoznać zdecydowaną większość patologii jelit, ich powikłań oraz skutków zastosowanej terapii. Dotyczy to przede wszystkim: chorób infekcyjnych, zapalnych, niedokrwiennych oraz różnego rodzaju nowotworów jelit. W przypadku zmian nowotworowych można z dużą dokładnością określić stopień miejscowego zaawansowania procesu, zwłaszcza dzięki endosonografii. W badaniu przezbrzusznym metoda ta uzyskuje wysokie wskaźniki diagnostyczne w ostrym zapaleniu wyrostka robaczkowego oraz w zapaleniu uchyłków jelita grubego, co decyduje o wyborze metody leczniczej. Ponadto wykazano jej wartość w niedrożności jelit i w rzadziej występujących zmianach, takich jak zapalenie przyczepków sieciowych oraz zawał sieci większej. Ultrasonografia ma niewielkie znaczenie w diagnostyce krwawienia z przewodu pokarmowego u pacjentów zagazowanych, otyłych i niewspółpracujących.

10

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine

72%

Godlewski J.

Folia Histochemica et Cytobiologica

|

2010

|

tom 48

|

nr 1

157-162

11

New species of Falcaustra (Nematoda: Kathlaniidae) in Batagur trivittata (Testudines: Geoemydidae) from Myanmar

72%

Bursey C. R. , Platt S. G.

Acta Parasitologica

|

2018

|

tom 63

|

nr 4

12

Ontogeny regulates creatine metabolism in rat small and large intestine

72%

Garcia-Miranda P. , Garcia-Delgado M. , Peral M. J. , Calonge M. L. , Ilundain A. A.

Journal of Physiology and Pharmacology

|

2009

|

tom 60

|

nr 3

127-133

EN

The ontogeny of intestinal CRT, AGAT and GAMT was investigated in foetuses, newborn, suckling, weaning and adult rats. In the colon, CRT mediates creatine transport because it was Na+- and Cl- dependent and inhibited by creatine and GPA. In addition, Northern assays showed two CRT transcripts (2.7-kb and 4.2-kb) and the in situ hybridisation revealed that CRT mRNA is restricted to the colon epithelial cells. The immunohistochemistry revealed that CRT protein was at the apical membrane of colon epithelia. Maturation decreased colonic CRT activity to undetectable levels and increased CRT mRNA abundance. Western assays revealed 57-, 65-, 80- and 116-kDa polypeptides at the intestinal apical membrane. The abundance of the 65-, 80- and 116-kDa polypeptides decreased with age, and that of 57-kDa was only observed in adult rats. The small and large intestine express AGAT and GAMT mRNAs. Maturation decreased AGAT mRNA abundance without affecting that of GAMT. For comparison, renal AGAT mRNA levels were measured and they were increased with age. The study reports for the first time that: i) the apical membrane of rat colon have an active CRT, ii) development down-regulates CRT activity via post-transcriptional mechanism(s), iii) the intestine might synthesize creatine and iv) intestinal and renal creatine synthesis is ontogenically regulated at the level of AGAT gene expression.

13

Evaluation of apoptosis, proliferation intensity and metallothionein [MT] expression in comparison with selected clinicopathological variables in primary adenocarcinomas of the large intestine

72%

Dumanska M. , Dziegiel P. , Sopel M. , Wojnar A. , Zabel M.

Folia Morphologica

|

2004

|

tom 63

|

nr 1

EN

Tumour growth and expansion are the result of proliferative activity and the capacity to eliminate cells by apoptosis and/or necrosis. The present study was aimed at comparing the apoptosis and proliferation intensity in cells of adenocarcinomas of the large intestine with the expression of metallothionein (MT), the grade of the tumour and the depth to which the tumour infiltrated the intestinal wall. The TUNEL technique and immunocytochemical reactions (expression of caspase-3, Ki-67, MT) were used to detect apoptosis. The results demonstrated augmented levels of all the variables examined, positively correlated with grade of malignancy, G, and with the depth of intestinal wall infiltration by the tumour cells. The testing of apoptosis, proliferation and MT expression may prove useful in the appraisal of the growth and progression of primary adenocarcinomas in the large intestine.

14

Anatomical structure and size of large intestinal mucosa in selected species of shrews and rodents

72%

Wilczynska B.

Acta Theriologica

|

1998

|

tom 43

|

nr 4

EN

The large intestine of eight Micro mammalia species, of the orders Insectivora (Sorex minutus, Sorex araneus) and Rodentia {Sicista betulina, Clethrionornys glareo- lus, Microtus oeconomus, Apodemus flauicollis, Mus musculus, Cavia porcellus) were studied. Both the length and surface area of the mucosa of the alimentary canal are strongly associated with food hydration, In M. oeconomus, feeding exclusively on green parts of plants, the large intestine dominates the totai length of the alimentary canal (35% of length). In omnivorous S. betulina and A. flavicollis, the length of the large intestine is 30% of total length of the canal and only 20% in M. musculus fed with dry and granulated food. The large intestine of the rodents (but S. betulina) is divided into caecum, colon and rectum. The caecum is best developed in M. oeconomus, where the relative value of the caecum is 5.54 mm/g and the surface area is 97.07 mm2/g of the body weight and least developed in M. musculus - 1.24 mm/g and 13.34 mmJ/g. In insectivorous shrews, the large intestine is very short and non-differentiated into segments. Its proportion in the length of the alimentary canal amounts only to 6.5%. The relative value of the length of the large intestine is between 1.34 mm/g of body weight (S, araneus) and 2.01 mm/g (S. minutus).

15

Frequency of occurrence of IgG against Helicobacter pylori in the blood serum of patients with giant adenoma of the large intestine

72%

Kopanski Z. , Wasilewska-Radwanska M. , Schlegel-Zawadzka M. , Witkowska B. , Cienciala A. , Jung A. , Kuc T.

|

tom 48

|

nr 1

16

Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the µ3 opiate receptor subtype: a hormonal role for endogenous morphine

72%

Stefano G. B. , Zhu W. , Cadet P. , Bilfinger T. V. , Mantione K.

Journal of Physiology and Pharmacology

|

2004

|

tom 55

|

nr 1,2

EN

Studies from our laboratory have revealed a novel µ opiate receptor, µ3, which is expressed in both human vascular tissues and leukocytes. The µ3 receptor is selective for opiate alkaloids, insensitive to opioid peptides and is coupled to constitutive nitric oxide (cNO) release. We now identify the µ3 receptor characteristics in mammalian gut tissues. It appears that the various regions of the mouse gut release low levels of NO (0.02 to 4.6 nM ) in a pulsatile manner. We demonstrate that morphine stimulates cNO release (peak level 17 nM) in the mouse stomach, small intestine and large intestine in a naloxone and L-NAME antagonizable manner. Opioid peptides do not exhibit cNO-stimulating capabilities in these tissues. Taken together, we surmise morphine acts as a hormone to limit gut activity via µ3 coupled to NO release since µ opiate receptors are found in the gut and endogenous morphine is not but is found in blood.

17

Nematodes of the large intestine of the European bison of the Bialowieza National Park

58%

Demiaszkiewicz A. W. , Pyziel A. M. , Kuligowska I. , Lachowicz J. , Krzysiak M. K.

Annals of Parasitology

|

2012

|

tom 58

|

nr 1

EN

The present study was conducted on 31 males and females of the European bison, eliminated during the winter seasons 2007–2011 in the Białowieża Primeval Forest, Poland. The caeca of 14 free-ranging bison, aged from 3 months up to 16 years, the most favorable infection site for the large intestine nematodes, were investigated during the winter of 2007/2008. The parasitological autopsies of the large intestines of 9 free-ranging bison aged from 5 months up to 10 years as well as 9 bison kept in the close reserves aged from one up to 20 years were done during the winter seasons of 2008–2011 to determine localization of nematodes in large intestine and the total intensity of parasite infection. Five species of nematodes (i.e., Trichuris ovis, Oesophagostomum venulosum, O. radiatum, Ashworthius sidemi, Nematodirus helvetianus) were found in dissected caecum of bison culled during the winter of 2007/2008. During the seasons of 2008–2010, 6 species of nematodes were found in the large intestine of bison (i.e., T. ovis, O. venulosum, O. radiatum, A. sidemi, N. roscidus and Bunostomum trigonocephalum). We did not find any nematodes in the lumen of the large intestine of captive bison culled during the seasons of 2010/2011. The results of the present study indicate that the intensity of infection by the large intestine nematodes of the European bison in the Białowieża Primeval Forest has stayed at the comparable level throughout the last 20 years; however the number of nematode species has increased. The observed level of parasitic infection is typical of subclinical parasitoses.

18

Mannanoligosaccharides or flavomycin in turkeys diets: effect on mucosa-associated microflora and growth performance

58%

Wasilewska E. , Ratowska J. , Bielecka M. , Zdunczyk Z. , Jankowski J.

|

2010

|

tom 19

|

nr 4

19

A dose-response effects of tannic acid and protein on growth performance, caecal fermentation, colon morphology, and beta-glucuronidase activity of rats

58%

Barszcz M. , Taciak M. , Skomial J.

Journal of Animal and Feed Sciences

|

2011

|

tom 20

|

nr 4

20

Falcaustra sanjuanensis sp. nov. (Nematoda: Kathlaniidae) from Odontophrynus cf. barrioi (Anura: Cycloramphidae) from Argentina

58%

Gonzalez C. E. , Sanabria E. A. , Quiroga L. B.

Acta Parasitologica

|

2013

|

tom 58

|

nr 1

EN

Here, we describe a new kathlaniid nematode, Falcaustra sanjuanensis sp. nov., from the large intestine of Odontophrynus cf. barrioi (Anura: Cycloramphidae), from San Juan Province, Argentina. The new species belongs to the Falcaustra group that possesses a pseudosucker. It resembles F. andrias in the distribution pattern of caudal papillae (six precloacal, four adcloacal, 12 postcloacal, one unpaired median anterior to the cloaca) but differs from F. andrias in the following characters: the longer size of males and females (11.17–13.45 mm and 10.1–15.5 mm, respectively); the longer size and form of the gubernaculum (0.17–0.23 mm, triangular form); the arrangement of postcloacal papillae (three pairs on the ventral side, two pairs on the lateral side, one pair on the subventral side) and unpaired papilla anterior to the cloaca located on the protuberance. The species description is based on light microscopy and scanning electron microscopy (SEM). Falcaustra sanjuanensis sp. nov. represents the 12th Neotropical species assigned to the genus. Also, we added a key to Neotropical species of Falcaustra.