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Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats

100%

Jin L. , Beswick R. A. , Yamamoto T. , Palmer T. , Taylor T. A. , Pollock J. S. , Pollock D. M. , Brands M. W. , Webb R. C.

nr 3

Hypertension is associated with increased reactive oxygen species (ROS). Renal ROS production and their effects on renal function have never been investigated in mineralocorticoid hypertensive rats. In this study we hypothesized that increased ROS production in kidneys from deoxycorticosterone (DOCA)-salt rats contributes to adverse renal morphological changes and impaired renal function in DOCA-salt hypertensive rats. We also determined whether ROS-induced renal injury was dependent on blood pressure. DOCA-salt hypertensive rats exhibited a marked increase in blood pressure, renal ROS production, glomerular and tubular lesions, and microalbuminuria compared to sham rats. Treatment of DOCA-salt hypertensive rats with apocynin for 28 days resulted in attenuation of systolic blood pressure and improvement of renal morphology. Renal superoxide level in DOCA-salt rats was 215% of sham-operated rats and it was significantly decreased to 140% with apocynin treatment. Urinary protein level was decreased from 27 ± 3 mg/day in DOCA-salt hypertensive rats to 9 ± 2 mg/day. 28 days of Vitamin E treatment also reduced renal injury in regard to urinary protein level and renal morphology but had no effect on blood pressure in DOCA-salt rats. Increased urinary 8-isoprostane, a marker for oxidative stress, in DOCA-salt hypertensive rats (55 ± 8 ng/day) was diminished by vitamin E treatment (24 ± 6 ng/day). These data suggest that renal injury characteristic of mineralocorticoid hypertension is associated with oxidative stress and is partly independent of blood pressure.

Increased AST/ALT ratio in azotaemic dogs infected with Babesia canis

84%

Zygner W. , Gojska-Zygner O. , Norbury L. J. , Wedrychowicz H.

Polish Journal of Veterinary Sciences

2012

tom 15

nr 3

The AST/ALT ratio was estimated in 182 dogs infected with Babesia canis. Among these dogs 65 had anaemia and 68 were azotaemic. Student’s t test was used to compare means of the AST/ALT ratio in anaemic and non-anaemic dogs, and in azotaemic and non-azotaemic dogs (p < 0.05). The differences in AST/ALT ratio between anaemic (1.52 ± 1.15) and non-anaemic (1.76 ± 1.34) dogs were statistically insignificant (p = 0.23), however, the comparison of AST/ALT ratio between azotaemic (2.68 ± 1.52) and non-azotaemic (1.08 ± 0.53) dogs revealed a significantly higher value of this index in azotaemic dogs (p = 0.00). The present results suggest that kidney injury contributed to increased AST activity in these dogs.

Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, uromodulin, and cystatin C concentrations in an experimental rat model of ascending acute kidney injury induced by pyelonephritis

84%

Skowron B. , Baranowska A. , Dobrek L. , Ciesielczyk K. , Kaszuba-Zwoinska J. , Wiecek G. , Malska-Wozniak A. , Strus M. , Gil K.

nr 4

Evaluation of serum and urine neutrophil gelatinase-associated lipocalin and cystatin C as biomarkers of acute kidney injury in horses

84%

Siwinska N. , Zak A. , Paslawska U.

nr 2

Galangin protects against oxidative damage and attenuates inflammation and apoptosis via modulation of NF-kappaB p65 and caspase-3 signaling molecules in a rat model of diabetic nephropathy

59%

Aladaileh S. H. , Al-Swailmi F. K. , Abukhalil M. H. , Shalayel M. H.

nr 1