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Content available remote N-acetyl-beta-glucosaminidase urine activity as a marker of early proximal tubule damage and a predictor of the long-term function of the transplanted kidneys
100%
Kwiatkowska E. , Domański L. , Bober J. , Kłoda K. , Safranow K. , Szymańska-Pasternak J. , Romanowski M. , Sulecka A. , Pawlik A. , Ciechanowski K.
Acta Biochimica Polonica
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2014
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tom 61
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nr 2
275-280
EN
Introduction: Ischaemia-reperfusion injury (IRI) is a factor leading to the damages of the transplanted kidney, what affects mainly the proximal tubules. Early monitoring of tubule damage can be an efficient tool to predict the allograft dysfunction. Present in proximal tubules, N-acetyl-beta-glucosaminidase (NAG) is a lysosomal enzyme whose excretion rises as a result of IRI or acute rejection. The aim of this study was to monitor the NAG urine activity to evaluate the early proximal tubule damage, and to try to predict the long-term function of the transplanted kidney. Material and methods: The study enrolled 87 Caucasian renal transplant recipients (61.7% males, 38.3% females, mean age 45.56±14.34 years). Urine samples were collected for NAG and creatinine analysis on the 1st day after transplantation, and then in the 3rd and 12th month. Protocol biopsies were performed in the 3rd and 12th month. Results: A significant positive correlation between NAG urine activity in the 3rd month after transplantation and creatinine concentration on the 14th (p=0.004) and 30th day (p=0.05), in the 3rd month (p=0.009) and after the 1st (p=0.005) and 2nd year (p=0.003) was observed. A statistically significantly higher urinary NAG activity in samples collected in the first 3 days and in the 3rd month after transplantation among patients with DGF (p=0.006 and p=0.03 respectively) was found. There was a significant positive correlation between NAG urine activity in the 3rd month and the grade of tubular atrophy in specimens collected in the 3rd (p=0.03) and 12th (p=0.04) month. Conclusions: Monitoring of NAG urine activity is useful in the evaluation of early proximal tubule damage and predicting the long-term function of the transplanted kidneys.
2
CTLA‑4 expression inversely correlates with kidney function and serum immunoglobulin concentration in patients with primary glomerulonephritides
86%
Grywalska E. , Smarz-Widelska I. , Mertowski S. , Gosik K. , Mielnik M. , Podgajna M. , Abramiuk M. , Drop B. , Rolinski J. , Zaluska W.
Archivum Immunologiae et Therapiae Experimentalis
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2019
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tom 67
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nr 5
3
Content available Effect of heat exposure on dehydration and kidney function among sea salt workers in Thailand
58%
Luangwilai T. , Robson M. G. , Siriwong W.
Roczniki Państwowego Zakładu Higieny
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2021
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tom 72
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nr 4
4
Content available Investigation of kidney function changes in sea salt workers during harvest season in Thailand
58%
Luangwilai T. , Robson M. G. , Siriwong W.
Roczniki Państwowego Zakładu Higieny
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2022
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tom 73
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nr 1
EN
Background. Occupational factors have previously been mentioned as contributing to decreased kidney function and the development of chronic kidney disease of unknown cause. Sea salt workers are one of the occupations facing high outdoor temperatures and a highly, intensive workload. Objective. The purpose of the study was to examine whether the kidney function of sea salt workers at the beginning of the harvest season differs from kidney function at the end of the harvest season and to identify factors that can predict the change of kidney function. Material and methods. Data were collected from salt workers (n=50) who were between 18–60 years of age without hypertension, diabetes, and kidney disease in Samut Sakhon province, Thailand. Urine specific gravity (USG) was used for hydration status and the estimated glomerular filter rate (eGFR) was used to measure kidney function. The mixed model was used to find differences over the harvest season and prediction of factors. Results. On average, the eGFR was estimated to decrease by 15.2 ml/min/1.73 m2 over the harvest season. The decline in eGFR of sea salt workers with moderate and heavy workloads were significantly faster than their light workload counterparts after controlling for other covariates. Similarly, dehydration (USG ≥ 1.030) significantly accelerated the rate of kidney function loss. Conclusions. Our study confirmed exposure to heat over the harvest season leads to decreased eGFR in sea salt workers. The rate of change of eGFR could be predicted by workload and hydration status. Workers with dehydration who performed medium to heavy workloads in farms showed faster kidney function decline than those who performed light workload.
5
Content available remote Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats
58%
Testerink J. , Degens H. , Rittweger J. , Shiraishi A. , Jaspers R. T. , De Haan A.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 1
EN
Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supra-physiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.
6
Content available High renin arterial hypertension due to occlusion of the adrenal veins in the rat
58%
Abramczyk P. , Przybylski J. , Lisiecka A. , Papierski K. , Ciszek B.
Journal of Physiology and Pharmacology
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1995
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tom 46
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nr 1
7
Content available The effect of nitrendipine on renal haemodynamics and tubular reabsorption and its neural control in anaesthetised rats with chronic renal failure
51%
Manitius J. , Johns E. J. , Chamienia A. L.
Journal of Physiology and Pharmacology
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1999
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tom 50
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nr 1
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