Wyniki wyszukiwania - Biblioteka Nauki

1

Treating kidney cancer – a review

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Piotr Przyczyna P. , David Aebisher D. , Dorota Bartusik-Aebisher D. , Ewa Kaznowska E.

European Journal of Clinical and Experimental Medicine

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2020

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nr 1

38-41

EN

Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.

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Wyniki leczenia operacyjnego raka nerki w I Klinice Urologii Uniwersytetu Medycznego w Łodzi w latach 2004–2010

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Kierstan A. , Jabłonowski Z. , Sosnowski M.

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nr 1

53-68

EN

Introduction. Aim of the study: The only effective treatment method for all forms of the kidney cancer is surgery with possible subsequent institution of neoadjuvant treatment. The standard management involves nephrectomy with or without lymphadenectomy and adrenalectomy. In patients with kidney tumors up to 4 cm in diameter, surgical procedures saving the renal parenchyma (Nephron-Sparing Surgery – NSS) are currently performed. The objective was the retrospective analysis of the treatment results obtained in renal cancer patients who had undergone surgical procedures. The results of the treatment following nephrectomy performed from transperitoneal and retroperitoneal approach were compared with those obtained after NSS type procedures. Material and methods: The study was carried out in 238 patients: 107 women and 131 men with kidney cancer, operated on in the years 2004 – 2010. In 15 patients distant metastases were found. The nephrectomy was performed in 69 patients from transperitoneal access and in 105 patients from retroperitoneal access with NSS procedures in 55 patients. The transperitoneal approach was used in patients with large tumors ranging > 6 cm size. Other patients were operated on with lumbar access, also those with tumors < 4 cm, since that approach was used for NSS procedures. The intraoperative and postoperative period, the duration of the surgery, complications, hospitalization time, analgesic treatment and overall survival were evaluated. Results: The operated patients were hospitalized for 11 days on the average, and the mean time of the surgical procedure was ca. 168 minutes. Intraoperative blood loss during most of the performed procedures was without clinical significance but the largest blood loss during the operation was reported in the patients with kidney tumors > 10 cm during transperitoneal access surgery. The blood loss was compensated in 33 cases by the administration of RBC preparations in 21.74% of the patients after transperitoneal access surgeries and 10.65% of those after lumbar access. Retroperitoneal access was associated with the use of larger quantities of analgesic medications in the postoperative period. Histopathological investigations resulted with clear cell carcinoma in 85% of the patients, in other 15% of the cases, most commonly diagnosed with chromophobe and papillary carcinomas. The malignancy grade of RCC according to Fuhrman scale; Fuhrman 1 – 7.98%, Fuhrman 2 – 61.38%, Fuhrman 3 – 9.66%, Fuhrman 4 – 5.88%. Fuhrman grades 3 and 4 were, however, more common in the patients with the big tumors undergoing transperitoneal access. The local advancement of the removed kidney tumors according to TNM classification: stage pT1 in 156 patients, stage pT2 in 52 and pT3 in 1 patient. The distribution of diagnoses and staging was similar for both surgical approaches. The results of kidney cancer treatment were reflected by the assessment of 5–year survival of the patients. Such analysis was possible only in the subgroup of 115 patients who had undergone the surgery in the years 2004 – 2007. The obtained data indicated the overall 5–year survival rate amounting to 58.3% of the reviewed subgroup, whereas 48 patients, i.e. 41.7% died. The causes of death were not possible to know. It is noteworthy that the group of deaths included all the patients operated on at the metastatic stage of the disease. Conclusions: In large renal tumors > 6 cm size, transperitoneal access nephrectomy was preferred. In the remaining patients lumbar access procedures were performed, including kidney-sparing surgery. Fuhrman grade 3 and 4 clear cell tumors are predominant in the patients operated on with transperitoneal access. The number of intra- and postoperative complications is similar in both groups. The use of transperitoneal access is associated with an increase in the amount of analgesics administered in the postoperative course, longer duration of the surgical procedure and longer hospitalization time. The overall 5–year survival rate for the group of 115 patients operated on in the years 2004–2007 was 58.3%.

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Automatic Extraction of the Pelvicalyceal System for Preoperative Planning of Minimally Invasive Procedures

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Heryan K. , Skalski A. , Jakubowski J. , Drewniak T. , Gajda J.

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nr 1

4

Zastosowanie metody zbiorów poziomicowych do wyodrębniania struktur naczyniowych w obrębie nerki w celu minimalizacji inwazyjności zabiegów onkologicznych

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Bugajska K. , Skalski A. , Drewniak T. , Gajda J.

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tom R. 91, nr 5

68-71

PL

W artykule zaproponowano zastosowanie algorytmów przetwarzania obrazów w celu wyodrębnienia struktur naczyniowych zlokalizowanych w obrębie nerki. Możliwość identyfikacji tętnic odżywiających guza nerki pozwala na jego usunięcie bez ryzyka wystąpienia urazu niedokrwiennego i przyczynia się do maksymalnego zabezpieczenia czynności nerki. Minimalizacja inwazyjności zabiegu usunięcia guza jest także korzystna dla pacjenta. Badania rozpoczęto od segmentacji struktur naczyniowych preparatów anatomicznych. Do ich wyodrębnienia zastosowano progowanie z histerezą, co pozwoliło na otrzymanie funkcji inicjalizującej dla metody zbiorów poziomicowych. Otrzymane wyniki potwierdziły skuteczność doboru metody - wizualnie ciągłość tych struktur była lepiej odtworzona względem samej binaryzacji, a granice obiektów były odpowiednio odwzorowane. Dodatkowo, analiza ilościowa polegająca na porównaniu otrzymanych wyników działania algorytmu z ręcznymi obrysami okazała się zadawalająca, co skłania do kontynuacji badań mogących stanowić o renoprotekcji.

EN

In the article we have proposed an application of several image processing algorithms to extract renal vessels. Earlier identification of the tumor feeding arteries facilitates conducting a zero-ischemia partial nephrectomy and preservation of renal function. This minimally invasive procedure is also beneficial for a patient. The study began with vascular structures segmentation of anatomical preparations. To do this hysteresis thresholding was applied to three dimensional computer tomography images. It allowed to obtain an initialization function for subsequently applied segmentation method – i.e. the level set method. The results confirmed the effectiveness of described methods - visually, in comparison to initial binarization, the acquired structures continuity had been found better and the objects boundaries were properly mapped. In addition, quantitative analysis involving the comparison of segmentation results with manual ones had been found satisfactory, that encourages to continue further research.

5

Metabolomic analysis of biological material using LC-MS in the quest for urinary system cancer biomarkers - review

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Szuberla W. , Wrona M.

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tom Vol. 4

70--75

EN

Renal cell carcinoma (RCC) and bladder cancer (BC) are among the most frequently diagnosed urinary system cancers worldwide. They are characterized by high mortality and recurrence rates. In response to the rising incidence and mortality rates, scientists are exploring innovative diagnostic and therapeutic methods. Metabolomics, which analyzes metabolite levels, may enable early diagnosis and monitoring of therapy progress. Compared to other omics technologies, it focuses on the outcomes of metabolite activity, providing a unique perspective on processes occurring in cancer cells. Metabolomic analyses utilize techniques such as mass spectrometry. These methods allow the identification of biomarkers and precise determination of the chemical composition of biological samples. However, the most commonly used method is liquid chromatography-mass spectrometry (LC-MS), which enables the most comprehensive screening of cancer metabolomes. Recent studies show significant progress in recognizing characteristic metabolites associated with urological cancers, although this area remains partially unexplored. Research on circulating metabolites, especially those present in easily accessible samples like blood or urine, demonstrates promising potential in clinical practice. Study results reveal differences in metabolic profiles between various stages of cancer development, which may have clinical significance. The future of this field involves an increasing number of clinical cohorts, standardization of sample preparation, and further improvements in instrument sensitivity and speed. LC-MS-based metabolomics has the potential to contribute to the improvement of diagnostics, therapy, and the quality of life of patients with some urological cancers. However, challenges, such as the lack of uniform methodologies and understanding of metabolite determinants, require further research and innovation.