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1

Deposition of Ru-106 and I-125 on silver by internal electrolysis

100%

Mielcarski M. , Puchalska I.

Nukleonika

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2002

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tom Vol. 47, nr 2

83-86

EN

The application of internal electrolysis for the deposition of ruthenium-106 and iodine-125 on silver was examined. These investigations were aimed at the preparation of sealed radiation sources for brachytherapy. The current and voltage of a cell built of silver cathode and aluminium anode, immersed in electrolytes containing different concentrations of ruthenium were determined. The same parameters were measured for the cell consisting of silver anode and platinum cathode as a function of the concentrations of NaI and NaOH in the electrolyte. The changes of current and voltage of the cells as a function of duration of electrolysis were investigated. The influence of white light observed during the deposition of iodine indicates that photolysis of silver iodide formed on the anode affects the cell parameters. From the results obtained it follows that electrolysis performed without application of external electric tension is a simple and convenient method for fixing considerable amounts of both ruthenium-106 and iodine-125 on silver.

2

Metastasis inhibition after proton beam, β- and γ-irradiation of melanoma growing in the hamster eye

86%

Romanowska-Dixon B. , Elas M. , Swakoń J. , Sowa U. , Ptaszkiewicz M. , Szczygieł M. , Krzykawska M. , Olko P. , Urbańska K.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

307-311

EN

Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development of spontaneous lung metastases. Tumors of Bomirski Hamster Melanoma (BHM) implanted into the anterior chamber of the hamster eye grew aggressively and completely filled the anterior chamber within 8-10 days. Metastases, mainly in the lung, were found in 100% of untreated animals 30 days after enucleation. Tumors were irradiated at a dose of 3-10 Gy with a 106Ru plaque and at a dose of 6-14 Gy using a 125I plaque. The protons were accelerated using the AIC-144 isochronous cyclotron operating at 60 MeV. BHM tumors located in the anterior chamber of the eye were irradiated with 10 Gy, for the depth of 3.88 mm. All radiation types caused inhibition of tumor growth by about 10 days. An increase in the number of metastases was observed for 3 Gy of β-irradiation, whereas at 10 Gy an inhibition of metastasis was found. γ-radiation reduced the metastatic mass at all applied doses, and proton beam therapy at 10 Gy also inhibited the metastastic spread. These results are discussed in the context of recent clinical and molecular data on radiation effects on metastasis.

3

Metastasis inhibition after proton beam, beta- and gamma-irradiation of melanoma growing in the hamster eye

58%

Romanowska-Dixon B. , Elas M. , Swakon J. , Sowa U. , Ptaszkiewicz M. , Szczygiel M. , Krzykawska M. , Olko P. , Urbanska K.

Acta Biochimica Polonica

|

2013

|

tom 60

|

nr 3

EN

Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development of spontaneous lung metastases. Tumors of Bomirski Hamster Melanoma (BHM) implanted into the anterior chamber of the hamster eye grew aggressively and completely filled the anterior chamber within 8-10 days. Metastases, mainly in the lung, were found in 100% of untreated animals 30 days after enucleation. Tumors were irradiated at a dose of 3-10 Gy with a 106Ru plaque and at a dose of 6-14 Gy using a 125I plaque. The protons were accelerated using the AIC-144 isochronous cyclotron operating at 60 MeV. BHM tumors located in the anterior chamber of the eye were irradiated with 10 Gy, for the depth of 3.88 mm. All radiation types caused inhibition of tumor growth by about 10 days. An increase in the number of metastases was observed for 3 Gy of β-irradiation, whereas at 10 Gy an inhibition of metastasis was found. γ-radiation reduced the metastatic mass at all applied doses, and proton beam therapy at 10 Gy also inhibited the metastastic spread. These results are discussed in the context of recent clinical and molecular data on radiation effects on metastasis.