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Association between intestinal and antioxidant barriers in children with cancer

100%

Stachowicz-Stencel T. , Synakiewicz A. , Owczarzak A. , Sliwinska A. , Lysiak-Szydlowska W. , Balcerska A.

Acta Biochimica Polonica

2012

tom 59

nr 2

237-242

Objective: Reactive oxygen species (ROS) play a role in cancerogenesis processing and damage tissues. Furthermore, oncological treatment may impair proper function of the gut barrier. The aim of this study was to measure intestinal permeability in children in clinical remission for solid tumours and to search for a possible relationship between free radicals and the intestinal barrier. No such investigation in children has been reported so far. Research Methods and Procedures: The prospective study consisted of 19 paediatric patients with cancer after completion of chemotherapy. 32 healthy children from the outpatients clinics were recruited for measurement of intestinal permeability and antioxidant barrier as a control group. Intestinal permeability was assessed by measurement of urinary lactulose and mannitol after oral challenge. Antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in erythrocytes were assessed. Ischemia modified albumin (IMA) concentration was measured in serum. Results: Cancer patients excreted less mannitol and more lactulose versus controls. The ratio of lactulose to mannitol was significantly higher in oncological children vs control (mean 0.188 and 0.0453, respectively, p=0.0006,). Significantly higher IMA level in the oncological group vs control was noted (mean 123.8 and 87.3 U/ml, respectively, p=0.0037). No correlation between intestinal permeability and oxidative stress barrier was found. Conclusions: Our data shows that intestinal barrier is damaged in paediatric cancer patients after chemotherapy. IMA is believed to play a protective role in the defence against tissue damage. No correlation was found between these two barriers.

Changes in intestinal permeability to 51Cr - ethylene - diaminetetraacetate [51Cr-EDTA] in animal infected with gastrointestinal nematodes

100%

Sinski E. , Uba P. , Maclean J. M.

Acta Parasitologica

1992

tom 37

nr 1

Permeability of the intestine to ⁵¹Cr-EDTA administered intragastrically was assessed in mice infected with Trichinella spiralis, in gerbils infected with Trichostrongylus colubriformis and in rabbits infected with Obeliscoides cuniculi. The results showed that, compared with the worm-free control animals, there was a significant increase in the recovery of ⁵¹Cr-EDTA in the urine five hours after the administration of the ⁵¹Cr-EDTA in all infected animals, about six times more in mice, ten times more in gerbils, and five times more in rabbits. Increased gut permeability appeared to be associated with changes in the mucosal surface of the gut, directly related to the action of the worms on the epithelium.

Assessment of intestinal permeability in preruminant calves by lactulose-mannitol test

75%

Klein P. , Moravcova J. , Kleinova T. , Volek Z. , Skrivanova V.

Journal of Animal and Feed Sciences

2007

tom 16

nr 1

43-52

Host nuclear factor erythroid 2-related factor 2 defense system determines the outcome of dextran sulfate sodium - induced colitis in mice

51%

Lee J. S. , An J. M. , Kang E. A. , Han Y. M. , Kim Y. S. , Lee H. J. , Kim K.-J. , Surh Y. J. , Hahm K.-B.

Journal of Physiology and Pharmacology

2018

tom 69

nr 5

Badanie przepuszczalności jelitowej - nowatorskie narzędzie diagnozy wielu chorób

51%

Kubica P. , Kot-Wasik A. , Namieśnik J. , Landowski P.

Analityka : nauka i praktyka

2012

tom nr 2

48-53

Diagnostyka przepuszczalności jelitowej ma kluczowe znaczenie w ocenie zaawansowania różnych chorób i schorzeń, a także pomaga w określeniu ogólnego stanu układu pokarmowego. Oznaczanie cukrów w moczu stanowi ciekawą alternatywę dla tradycyjnych metod gastroskopowych, kolonoskopowych i biopsji.