Wyniki wyszukiwania - Biblioteka Nauki

1

Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells

100%

Radomska-Lesniewska D. M. , Sadowska A. M. , Van Overveld F. J. , Demkow U. , Zielinski J. , De Backer W. A.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

325-334

EN

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. The initial step in the inflammatory process is overexpression of adhesion molecules, which leads to excessive transmigration of neutrophils. One of these adhesion molecules is ICAM-1 which is elevated in COPD patients. In this study we evaluated the influence of N-acetylcysteine (NAC) (0.01 mM-30 mM) on the cytokine-induced (TNF-alphalpha/IL-1ß) expression of the ICAM-1 adhesion molecule and on IL-8 release in endothelial (ECV-304) and bronchial epithelial (H292) cell lines. The methodology used consisted of immunochemistry for the assessment of surface ICAM-1 and ELISA method for that of soluble ICAM-1 and IL-8. NAC inhibited the TNF-alphalpha/IL-1ß-stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner. The most effective concentrations were 30 mM and 20 mM (99 and 90% inhibition respectively, P<0.01). We conclude that NAC is an effective inhibitor of TNF-alphalpha/IL-1ß- stimulated ICAM-1 and IL-8 release in endothelial and epithelial cells. This fact highlights the anti-inflammatory potential of NAC in COPD.

2

Elastase, alpha1-proteinase inhibitor, and interleukin-8 in children and young adults with end-stage kidney disease undergoing continuous ambulatory peritoneal dialysis

100%

Polanska B. , Augustyniak D. , Makulska I. , Niemczuk M. , Jankowski A. , Zwolinska D.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 3

3

IP6 modulates interleukin-8 secretion in colon epithelial cells by influencing various signalling pathways

100%

Weglarz L. , Wawszczyk J. , Orchel A. , Dzierzewicz Z.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

4

Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-alpha in human dermal microvascular endothelial cells

84%

Del Socorro Pina-Canseco M. , Paez-Arenas A. , Masso F. , Perez-Campos E. , Martinez-Cruz R. , Hernandez-Cruz P. , Majluf-Cruz A. , Martinez-Cruz M. , Perez-Campos Mayoral L. , Perez-Santiago A. D. , Zenteno E.

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tom 50

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nr 3

5

Prolonged treatment with inhaled corticosteroids does not normalize high activity of matrix metalloproteinase-9 in exhaled breath condensates of children with asthma

84%

Grzela K. , Zagorska W. , Krejner A. , Litwiniuk M. , Zawadzka-Krajewska A. , Banaszkiewicz A. , Kulus M. , Grzela T.

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tom 63

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nr 3

6

Exhaled IL-8 in systemic lupus erythematosus with and without pulmonary fibrosis

84%

Nielepkowicz-Gozdzinska A. , Fendler W. , Robak E. , Kulczycka-Siennicka L. , Gorski P. , Pietras T. , Brzezianska E. , Antczak A.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 3

7

Host response to the presence of Helicobacter spp. DNA in the liver of patients with chronic liver diseases

84%

Rybicka M. , Nakonieczna J. , Stalke P. , Bielawski K. P.

Polish Journal of Microbiology

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2011

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tom 60

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nr 2

EN

Literature data indicate an association between the presence of Helicobacter spp. in the liver and the development of hepatocellular carcinoma (HCC). However, the role of H. pylori infections in chronic liver diseases (CLD) remains controversial. The aim of this study was to detect Helicobacter spp. DNA in patients with CLD, and to investigate the host response to the presence of the bacterium in the liver. Helicobacter spp. DNA was detected in 59% samples. H.pylori was the most prevalent species (94%). We estimated the expression level of IL-1 and IL-8 genes. The presence of Helicobacter spp. did not have a significant effect on the gene expression of IL-8 and IL-1.

8

Selected clinical features fail to predict inflammatory gene expressions for TNF‑alpha, TNFR1, NSMAF, Casp3 and IL‑8 in tendons of patients with rotator cuff tendinopathy

84%

Struzik S. , Czarkowska‑Paczek B. , Wyczalkowska‑Tomasik A. , Maldyk P. , Paczek L.

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2021

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tom 69

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nr 1

9

The role of local and systemic cytokines in patients infected with Clostridium difficile

84%

Czepiel J. , Biesiada G. , Brzozowski T. , Ptak-Belowska A. , Perucki W. , Birczynska M. , Jurczyszyn A. , Strzalka M. , Targosz A. , Garlicki A.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 5

10

Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury

84%

Kim E. K. , Cho J. H. , Jeong A. R. , Kim E. J. , Park D. K. , Kwon K. A. , Chung J. W. , Kim K. O. , Kim J. H. , Kim J. H. , Kim Y. J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 1

11

Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and STNFR55-TNFR75 in plasma of patients with acute pancreatitis

84%

Naskalski J. W. , Kusnierz-Cabala B. , Panek J. , Kedra B.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 3

EN

Plasma pancreatic-type Poly-C specific ribonuclease (P-RNase) - enzyme activity increases in patients with acute pancreatitis (AP) who develop pancreatic necrosis and severe disease course. It is considered as a marker of pancreatic tissue destruction. The aim of this study was to estimate interrelations between major inflammatory cytokines such as: interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor soluble receptors: sTNFR55 and sTNFR75 output, and plasma P-RNase activity. The study was carried out in a group of 56 patients with AP, where 20 developed pancreatic necrosis. It was found that serum P-RNase concentration and levels of all studied inflammatory cytokines significantly increase already in the first day from diagnose of the disease (2,5 folds for P-RNase, 20 for IL-8, about 200 for IL-6 and 1,5 for receptors, respectively). In the first day from admission to hospital, P-RNase activity significantly correlated with plasma concentration of studied inflammatory cytokines. The most pronounced correlation was found for P-RNase and IL-6 in days 1-4 from diagnose, manifested by Pearson correlation r coefficients amounting to 0,86; 0,79; 0,60 and 0,57 respectively (p<0,001). Dividing the studied AP patients into two groups, varying in severity of disease a significant differences in P-RNase and IL-6, IL-8 and sTNFR55/sTNFR75 were found. In patients with acute necrotizing pancreatitis P-RNase significantly correlate with levels of major inflammatory cytokines. Carried out studies suggest that activity of P-RNase reflects severity of inflammatory reaction, which is dependent on development of pancreatic injury and tissue necrosis in AP.

12

High level expression of STAG1-PMEPA1 in an androgen-independent prostate cancer PC3 subclone

84%

Hirokawa Y. S. , Takagi A. , Uchida K. , Kozuka Y. , Yoneda M. , Watanabe M. , Shiraishi T.

Cellular and Molecular Biology Letters

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2007

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tom 12

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nr 3

EN

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

13

The neutrophil-activating peptide 1-interleukin 8, a novel neutrophil chemotactic cytokine

84%

Schroder J. M.

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1992

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tom 40

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nr 1

14

Desulfovibrio desulfuricans lipopolysaccharides induce endothelial cell IL-6 and IL-8 secretion and E-selectin and VCAM-1 expression

84%

Weglarz L. , Dzierzewicz Z. , Skop B. , Orchel A. , Parfiniewicz B. , Wisniowska B. , Swiatkowska L. , Wilczok T.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 4

EN

The aim of this study was to determine whether Desulfovibrio desulfuricans-derived LPS stimulate the release of IL-6 and IL-8 from ECs and the expression of their adhesion molecules at the transcriptional level. Confluent monolayers of HUVEC were incubated in the absence or presence of 20 μg/ml and 60 μg/ml LPSs derived from the DdT and DdA bacterial strains. Also, the simultaneous stimulation of cells with LPSs and IL-1β was evaluated. The levels of cytokines released were measured using ELISA. LPS-activated HUVEC increased the secretion of both IL-6 and IL-8, which was not LPS dose dependent. The expression of E-selectin and VCAM-1 was assessed by TR-PCR. The transcripts were detectable at all the concentrations (20, 40, 60 μg/ml) of LPSs used. These results suggest that D. desulfuricans LPS may activate immune functions in endothelial cells and influence the inflammatory response during bacteremia caused by these bacteria.

15

Glycoconjugates with NeuAc-NeuAc-Gal-Glc are more effective at preventing adhesion of Helicobacter pylori to gastric epithelial cells than glycoconjugates with NeuAc-Gal-Glc

84%

Hata Y. , Murakami M. , Okabe S.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 3

EN

Helicobacter pylori (H. pylori) adheres to human gastric epithelial cells, eliciting various gastroduodenal diseases. Gangliosides play a critical role in bacterial adhesion to cell surfaces. The present study examined how residues of gangliosides are important for inhibition of adhesion of H. pylori to MKN-45 cells. We measured adhesion or detachment effects of gangliosides on the interaction between MKN-45 cells and H. pylori, as well as interleukin-8 production. Among the gangliosides, O-Ac-GD3, GT1b, GD1a, GD1b, GT1a, and GD3 had potent dose dependent inhibitory effects on adhesion of H. pylori to MKN-45 cells, interleukin-8 production, and vacuole formation induced by H. pylori toxin binding to Vero cells. GD3 also accelerated bacterial detachment of MKN-45 cells with adherent H. pylori in a dose dependent manner. Such results strongly suggest that the mechanism involved in the inhibition of H. pylori adhesion is mediated by the variations of the residues of the NeuAc-NeuAc-Gal-Glc chain of gangliosides. NeuAc-NeuAc-Gal-Glc exhibits a more inhibitory effect on adhesion than the NeuAc-Gal-Glc chain. Such gangioside and oligosaccrharide sequences appear to have therapeutic importance for prevention of H. pylori adhesion, as well as reduction of both inflammation and gastric mucosal injuries.

16

Pro-inflammatory cytokine release in rectal surgery: comparison between laparoscopic and open surgical techniques

67%

Kvarnstrom A. , Swartling T. , Kurlberg G. , Bengtson J.-P. , Bengtsson A.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 5

17

Modulatory effect of sera from sarcoidosis patients on mononuclear cell-induced angiogenesis

67%

Zielonka T. M. , Demkow U. , Bialas B. , Filewska M. , Zycinska K. , Radzikowska E. , Szopinski J. , Skopinska-Rozewska E.

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2007

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tom 58

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nr 5

18

Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy

67%

Sugimoto M. , Yamaoka Y.

Archivum Immunologiae et Therapiae Experimentalis

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2009

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tom 57

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nr 1

45-56

19

Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion

67%

Zelazowska-Rutkowska B. , Ilendo E. , Skotnicka B. , Wysocka J. , Kasprzycka E.

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tom 50

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nr 4

20

Blood specimen biomarkers of inflammation, matrix degradation, angiogenesis, and cardiac involvement: a future useful tool in assessing clinical outcomes of COPD patients in clinical practice?

67%

Kristan S. S.

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nr 6