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  1. 12 Archivum Immunologiae et Therapiae Experimentalis
  2. 5 Journal of Physiology and Pharmacology. Supplement
  3. 4 Acta Biochimica Polonica
  4. 4 Acta Parasitologica
  5. 4 Folia Histochemica et Cytobiologica
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  1. 2 2021
  2. 2 2020
  3. 1 2018
  4. 2 2016
  5. 1 2015
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  1. 7 Szala S.
  2. 3 Cichon T.
  3. 3 Smolarczyk R.
  4. 3 Stasiak-Barmuta A.
  5. 2 Chyczewska E.
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1
Content available remote Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis
100%
Mroz R. M. , Korniluk M. , Stasiak-Barmuta A. , Chyczewska E.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
|
nr 6
507-513
2
Antitumor effects of recombinant antivascular protein ABRaA-VEGF121 combined with IL-12 gene therapy
100%
Ciomber A. , Smagur A. , Mitrus I. , Cichon T. , Smolarczyk R. , Sochanik A. , Szala S. , Jarosz M.
Archivum Immunologiae et Therapiae Experimentalis
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2014
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tom 62
|
nr 2
3
Cytokine-based immunotherapy of allergic disease
100%
Lewkowich I. P. , HayGlass K. T.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
|
tom 49
|
nr 4
4
Tumor-resident CD8plus T-cell: the critical catalyst in Il-12-mediated reversal of tumor immune suppression
84%
Egilmez N. K. , Kilinc M. O.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
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tom 58
|
nr 6
399-405
5
Increased level of soluble adenosine deaminase in bone marrow of visceral leishmaniasis patients: an inverse relation with parasite load
84%
Rai A. K. , Kumar P. , Saini S. , Thakur C. P. , Seth T. , Dipendra D. K.
Acta Parasitologica
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2016
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tom 61
|
nr 3
6
Content available remote Interferon gamma production in the course of Mycobacterium tuberculosis infection
84%
Winek J. , Rowinska-Zakrzewska E. , Demkow U. , Szopinski J. , Szolkowska M. , Filewska M. , Jagodzinski J. , Roszkowski-Sliz K.
Journal of Physiology and Pharmacology. Supplement
|
2008
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tom 59
|
nr 6
751-759
7
Combined tumor cell-based vaccination and interleukin-12 gene therapy polarizes the tumor microenvironment in mice
84%
Jarosz-Biej M. , Smolarczyk R. , Cichon T. , Kulach N. , Czapla J. , Matuszczak S. , Szala S.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
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tom 63
|
nr 6
8
Content available remote Upregulation of Th1 cytokine profile in bronchoalveolar lavage fluid of patients with hypersensitivity pneumonitis
84%
Mroz R. M. , Korniluk M. , Stasiak-Barmuta A. , Chyczewska E.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 6
499-505
9
The effect of Naja naja oxiana snake venom against Leishmania tropica confirmed by advanced assays
84%
Sharifi I. , Tabatabaie F. , Nikpour S. , Mostafavi M. , Oliaee R. T. , Sharifi F. , Babaei Z. , Jafari E. , Salarkia E. , Shahbazzadeh D.
Acta Parasitologica
|
2021
|
tom 66
|
nr 2
10
Current status of M1 and M2 macrophages pathway as drug targets for inflammatory bowel disease
84%
Seyedizade S. S. , Afshari K. , Bayat S. , Rahmani F. , Momtaz S. , Rezaei N. , Abdolghaffari A. H.
Archivum Immunologiae et Therapiae Experimentalis
|
2020
|
tom 68
|
nr 2
11
Immunocytochemical analysis of the tissue location of cytokines [IL-2 and IL-12] in neuroendocrine lung cancer
84%
Kasprzak A. , Przewozna M. , Zabel M. , Pankowski J. , Surdyk-Zasada J.
Folia Morphologica
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2003
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tom 62
|
nr 3
301-303
EN
The study aimed at immunocytochemical evaluation of the cellular expression of two cytokines, IL-2 and IL-12 in lung carcinoids (n = 10), following the earlier demonstration of two markers of endocrine tumours (chromogranin A and NSE — neuron-specific enolase). In the immunocytochemical studies the classical avidin-biotinylated peroxidase (ABC) technique was used. Results of the tests were semiquantitatively appraised employing the IRS scale. In 9/10 cases intense reaction (score: 6–12 points) was noted for both lung neuroendocrine markers. In all cases of carcinoma co-expression of IL-2 and IL-12 was demonstrated in cells of the tumours. The cytokines showed a cytoplasmic localisation of mean (score: 3–4 points) or high (score: 6–12 points) intensity of reaction. Our studies point to a possible role of the two cytokines in the proliferation of lung neuroendocrine carcinomas but more detailed analysis is required on a broader material.
12
Combined delivery of an antiangiogenic protein [angiostatin] and an immunomodulatory gene [interleukin-12] in the treatment of murine cancer
84%
Wilczynska U. , Kucharska A. , Szary J. , Szala S.
Acta Biochimica Polonica
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2001
|
tom 48
|
nr 4
EN
We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein admin­istration), this produced a synergistic therapeutic effect.
13
Combination of IL-12 gene therapy and CTX chemotherapy inhibits growth of primary B16[F10] melanoma tumors in mice
84%
Mitrus I. , Delic K. , Wrobel N. , Missol-Kolka E. , Szala S.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr 2
EN
We investigated suppression of murine B16(F10) melanoma tumor growth following a therapy which involved concomitant administration of cyclophosphamide and plasmid DNA bearing interleukin-12 gene. Since both therapeutic factors display antiangiogenic capabilities, we assumed that their use in blocking the formation of new blood vessels would result in augmented inhibition of tumor growth. This combined therapy regimen indeed resulted in a considerable suppression of tumor growth. We observed a statistically significant extension of treated animals' lifespan. Interestingly, the therapeutic effect was also obtained using a plasmid without an interleukin gene insert. This observation suggests that plasmid DNA, which has been widely applied for treating neoplastic tumors, contains element(s) that elicit immune response in mice.
14
Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27
84%
Beadling C. , Slifka M. K.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 1
15
Tumor-associated macrophages as target for antitumor therapy
67%
Sawa-Wejksza K. , Kandefer-Szerszen M.
Archivum Immunologiae et Therapiae Experimentalis
|
2018
|
tom 66
|
nr 2
16
Gamma delta T cell positively regulate contact sensitivity (CS) reaction via modulation of INF-gamma, IL-12 and TNF-alpha production
67%
Strzępa A. , Majewska-Szczepanik M. , Szczepanik M.
Folia Biologica
|
2013
|
tom 61
|
nr 3-4
17
In vitro IL-4, IL-12, and IFN-gamma production by splenocytes from Ancylostoma ceylanicum infected hamsters
67%
Dlugosz E. , Wisniewski M. , Wojcik L. , Wedrychowicz H.
Bulletin of the Veterinary Institute in Puławy
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2010
|
tom 54
|
nr 3
EN
The aim of the study was the production of chicken polyclonal antibodies recognising hamster IL-4, IL-12p35, and IFN-γ, which were further used to estimate cytokine concentrations in splenocyte culture supernatants, obtained from three age groups of Ancylostoma ceylanicum infected hamsters. Worm burdens differed significantly among age groups; the younger animals were the more heavily infected. Th1 and Th2 type cytokines were detected only in cultures containing spleen cells from the oldest hamsters, which were the most resistant to hookworm infection. In cultures of cells from young more susceptible hamsters, the presence of IL-4 and IL-12 but not IFN-γ were observed.
18
Antitumoral effect of IL-12 gene transfected via liposomes into B16F0 cells
67%
Speroni L. , Gasparri J. , de los A.Bustuoabad V. , Chiaramoni N. S. , Smagur A. , Szala S. , Taira M. C. , del V.Alonso S.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 2
249-253
EN
 Murine melanoma B16F0 cells were transfected with SA:DPPC:DOPE (2:1:1 molar ratio) liposomes associated with a plasmid encoding murine IL-12. Stearylamine, a cationic lipid, showed a greater transfection efficiency compared to DOTAP-containing liposomes. The lipid:DNA ratio was 2:1 (w/w). Control groups were mock transfected or transfected with an empty plasmid (pNeo). pNeo or IL-12 transfected cells and controls were inoculated intradermically into the dorsal region of the foot or the lateral flank of C57BL6 mice. Results showed that IL-12 expression had a marked effect on in vivo growth of B16 melanoma tumors developed in both anatomic sites, significantly retarding their growth and prolonging host survival.
19
Interleukin-27: biological properties and clinical application
67%
Jankowski M. , Kopinski P. , Goc A.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
|
tom 58
|
nr 6
417-425
20
Evaluation of CD40, its ligand CD40L and Bcl-2 in psoriatic patients
67%
Mysliwiec H. , Flisiak I. , Baran A. , Gorska M. , Chodynicka B.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 1
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