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  1. 21 Archivum Immunologiae et Therapiae Experimentalis
  2. 10 Folia Histochemica et Cytobiologica
  3. 10 Journal of Physiology and Pharmacology
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  5. 4 Acta Biochimica Polonica
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  1. 3 2021
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  1. 3 Ceranowicz P.
  2. 3 Dembinski A.
  3. 3 Konturek S. J.
  4. 3 Stachura J.
  5. 3 Stelmaszczyk-Emmel A.
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1
Content available remote Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells
100%
Walos S. , Szary J. , Szala S.
Acta Biochimica Polonica
|
1999
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tom 46
|
nr 4
967-970
EN
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10  tumor growth was decreased depending on the amount of secreted IL-10.
2
Human T regulatory cells: on the way to cognition
75%
Kaczorowski M. , Jutel M.
Archivum Immunologiae et Therapiae Experimentalis
|
2013
|
tom 61
|
nr 3
3
Expanding diversity and common goal of regulatory T and B cells. I: origin, phenotype, mechanisms
75%
Bocian K. , Kiernozek E. , Domagala-Kulawik J. , Korczak-Kowalska G. , Stelmaszczyk-Emmel A. , Drela N.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 6
4
Haemoglobin scavenger receptor: function in relation to disease
75%
Zuwala-Jagiello J.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr 2
EN
Highly efficient systems remove the toxic and proinflammatory haemoglobin from the circulation and local sites of tissue damage. Macrophages are major haemoglobin-clearing cells; CD163 was recently recognized as the specific haemoglobin scavenger receptor (HbSR). It is tightly involved in both physiological as well as pathophysiological processes, such as cytoprotection and inflammation. Haemoglobin functions as a double-edged sword. In moderate quantities and bound to haptoglobin, it forms a ligand for haemoglobin scavenger receptor CD163/HbSR, but when unleashed in large amounts, it can become toxic by mediating oxidative stress and inflammation. CD163/HbSR plays a crucial role in the control of inflammatory processes, probably in part through its effects on both ferritin induction and subsequent induction of antiinflammatory pathways through interleukin-10 and haem oxygenase. Besides the observation that the haemoglobin scavenger receptor provides a promising target for new treatment possibilities, it offers a novel view on the aetiology of diverse physiological as well as pathophysiological processes. In addition, monocyte CD163/HbSR and soluble CD163/HbSR are potential diagnostic tools in a variety of disease states, such as inflammation, atherosclerosis, transplant rejection, and carcinoma.
5
Content available remote IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis
75%
Warzecha Z. , Dembinski A. , Ceranowicz P. , Konturek S. J. , Tomaszewska R. , Stachura J. , Konturek P. C.
Journal of Physiology and Pharmacology
|
2003
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tom 54
|
nr 4
EN
Insulin-like growth factor-1 (IGF-1) and other growth factors overexpression was reported in acute pancreatitis. Previous studies have shown the protective effect of epidermal growth factor (EGF), Hepatocyte Growth Factor (HGF) and Fibroblast Growth Factor (FGF) in the course of experimental acute pancreatitis. The aim of our studies was to determine the effect of IGF-1 administration on the development of caerulein-induced pancreatitis. Methods: Acute pancreatitis was induced by infusion of caerulein (10 µg/kg/h) for 5 h. IGF-1 was administrated twice at the doses: 2, 10, 50, or 100 µg/kg s.c. Results: Administration of IGF-1 without induction of pancreatitis increased plasma interleukin-10 (IL-10). Infusion of caerulein led to development of acute edematous pancreatitis. Histological examination showed pancreatic edema, leukocyte infiltration and vacuolization of acinar cells. Also, acute pancreatitis led to an increase in plasma lipase and interleukin 1ß (IL-1ß) level, whereas pancreatic DNA synthesis and pancreatic blood flow were decreased. Treatment with IGF-1, during induction of pancreatitis, increased plasma IL-10 and attenuated the pancreatic damage, what was manifested by histological improvement of pancreatic integrity, the partial reversion of the drop in pancreatic DNA synthesis and pancreatic blood flow, and the reduction in pancreatitis-evoked increase in plasma amylase, lipase and IL-1ß level. Protective effect of IGF-1 administration was dose-dependent. Similar strong protective effect was observed after IGF-1 at the dose 2 x 50 and 2 x 100 µg/kg. Conclusions: (1) Administration of IGF-1 attenuates pancreatic damage in caerulein-induced pancreatitis; (2) This effect is related, at least in part, to the increase in IL-10 production, the reduction in liberation of IL-1ß and the improvement of pancreatic blood flow.
6
Increased level of soluble adenosine deaminase in bone marrow of visceral leishmaniasis patients: an inverse relation with parasite load
63%
Rai A. K. , Kumar P. , Saini S. , Thakur C. P. , Seth T. , Dipendra D. K.
Acta Parasitologica
|
2016
|
tom 61
|
nr 3
7
Comparative expression analysis of inflammatory and immune-related genes in cattle during acute infection with foot-and-mouth disease virus in Egypt
63%
El Nahas A. F. , Abd El Naby W. S. H. , Khatab S. A. , Fergany A.-Z. A. , Rashed R. R.
Journal of Veterinary Research
|
2021
|
tom 65
|
nr 1
8
The immunomodulatory activity of Staphylococcus aureus products derived from biofilm and planktonic cultures
63%
Sadowska B. , Wieckowska-Szakiel M. , Paszkiewicz M. , Rozalska B.
Archivum Immunologiae et Therapiae Experimentalis
|
2013
|
tom 61
|
nr 5
9
Monocytic MDSC as a source of immunosuppressive cytokines in chronic lymphocytic leukemia (CLL) microenvironment
63%
Kowalska W. , Bojarska-Junak A.
Folia Histochemica et Cytobiologica
|
2020
|
tom 58
|
nr 1
10
Low frequency of regulatory T cells in the peripheral blood of children with type 1 diabetes diagnosed under the age of five
63%
Szypowska A. , Stelmaszczyk-Emmel A. , Demkow U. , Luczynski W.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 4
11
Plasma TNF-alpha and IL-10 level-based prognostic model predicts outcome of patients with diffuse large B-cell lymphoma in different risk groups defined by the International Prognostic Index
63%
Lech-Maranda E. , Bienvenu J. , Broussais-Guillaumat F. , Warzocha K. , Michallet A.-S. , Robak T. , Coiffier B. , Salles G.
|
|
tom 58
|
nr 2
131-141
12
The therapeutic potential of interleukin 10 in infection and inflammation
63%
Kumar A. , Creery W. D.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 6 Spec.Iss.
529-538
13
Content available remote The role of local and systemic cytokines in patients infected with Clostridium difficile
63%
Czepiel J. , Biesiada G. , Brzozowski T. , Ptak-Belowska A. , Perucki W. , Birczynska M. , Jurczyszyn A. , Strzalka M. , Targosz A. , Garlicki A.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 5
14
Effects of resveratrol on the expression and DNA methylation of cytokine genes in diabetic rat aortas
63%
Lou X.-D. , Wang H.-D. , Xia S.-J. , Skog S. , Sun J.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
|
tom 62
|
nr 4
15
IgG from non-atopic individuals induces in vitro IFN-gamma and IL-10 production by human Intra-thymic gamma deltaT cells: a comparison with atopic IgG and IVIg
63%
Souza Santos L. , da Ressureicao Sgnotto F. , Inoue A. H. S. , Padreca A. F. , Menghini R. P. , da Silva Duarte A. J. , Victor J. R.
Archivum Immunologiae et Therapiae Experimentalis
|
2019
|
tom 67
|
nr 4
16
Content available The presence of CD25 on bovine WC1 plus gamma delta T cells is positively correlated with their production of IL-10 and TGF-beta, but not IFN-gamma
63%
Maslanka T. , Jaroszewski J. J. , Markiewicz W. , Ziolkowski H. , Barski D.
Polish Journal of Veterinary Sciences
|
2012
|
tom 15
|
nr 1
EN
WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-γ and IL-10 seems to be related to WC1+ cells’ effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells. Due to increasingly frequent emphasised role of consumption of IL-2 in the mechanism of suppressor action of mouse CD25+CD4+ T regulatory cells, expression of the receptor’s α chain for interleukin 2 (CD25) on WC1+ lymphocytes has been evaluated. An average of 5.21% of WC1+ cells obtained from PBMCs of 12-month-old heifers show constitutive expression of the CD25 molecule, with CD25highWC1+ and CD25lowWC1+ cells accounting for 1.05% and 4.10% of WC1+ lymphocytes, respectively. For detection of intracellular cytokine production, PBMCs were stimulated with concanavalin A. Both IFN-γ- and IL-10-producing cells within the CD25-WC1+ and CD25+WC1+ subpopulations were mainly separate subpopulations. The average percentage of IFN-γ+IL-10-, IFN-γ-IL-10+ and IFN-γ+IL-10+ cells among CD25-WC1+ lymphocytes was 4.03%, 2.67% and 0.51%, respectively. A positive correlation was observed between the presence of the CD25 molecule on WC1+ lymphocytes and production of IL-10 and TGF-β, because the average percentage of IFN-γ-IL-10+ and IFN-γ+IL-10+ among CD25+WC1+ lymphocytes was 3 and 4.5 times higher as compared to the corresponding cells in the CD25-WC1+ subpopulation, whereas the percentage of IFN-γ+IL-10- cells in both the subpopulations was not significantly different. The percentage of TGF-β+ cells within the CD25+WC1+ subpopulation was 2.72 times as high as that of CD25-WC1+ lymphocytes. Therefore, with respect to the production of IFN-γ, IL-10 and TGF-β, CD25+WC1+ lymphocytes turn out to have a more suppressor profile than CD25-WC1+.
17
Inhibition of tumor growth by interleukin 10 gene transfer in B16[F10] melanoma cells
63%
Walos S. , Szary J. , Szala S.
|
|
nr 4
EN
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.
18
Content available Pancreatic damage and regeneration in the course of ischemia-reperfusion induced pancreatitis in rats
63%
Dembinski A. , Warzecha Z. , Ceranowicz P. , Stachura J. , Tomaszewska R. , Konturek S. J. , Sendur R. , Dembinski M. , Pawlik W. W.
Journal of Physiology and Pharmacology
|
2001
|
tom 52
|
nr 2
19
Gene therapy for autoimmune demyelinating disease of the central nervous system
63%
Mathisen P. M. , Tuohy V. K.
Archivum Immunologiae et Therapiae Experimentalis
|
1999
|
tom 47
|
nr 1
20
Abnormal cytokine production by bone marrow stomal cells of multiple myeloma patients in response to RPMI8226 myeloma cells
63%
Zdzisinska B. , Bojarska-Junak A. , Dmoszynska A. , Kandefer-Szerszen M.
Archivum Immunologiae et Therapiae Experimentalis
|
2008
|
tom 56
|
nr 3
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