A series containing twelve titled compounds were synthesized by solvent-free method and their purities were examined by literature procedure. These compounds were subjected to study the pharmacological effects such as antibacterial, antifungal and antioxidant activities and the insect antifeedant activities using Bauer-Kirby disc diffusion method with their bacterial and fungal strains, DPPH radical scavenging and leaf disc bio-assay method with 4th instar larvae Achoea janata L.
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A series of (5-chloro-2-thienyl)(3-(substituted phenyl) bicyclo [2.2.1] hept-5-en-2-yl) methanones have been synthesized by fly-ash catalyzed [4+2] cycloaddition Diels-Alder reaction of cyclopentadiene and 5-chloro-2-thienyl chalcones under cooling conditions. The yields of the methanones are more than 60%. The synthesized (5-chloro-2-thienyl)(3-(substituted phenyl) bicyclo [2.2.1] hept-5-en-2-yl) methanones are characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of synthesized methanones have been studied using their respective bacterial, fungal strains, DPPH radical scavenging activity and Dethler’s leaf-discs bioassay method.
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