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Macrophage migration inhibitory factor and its role in autoimmune diseases

100%

Denkinger C. M. , Metz C. , Fingerle-Rowson G. , Denkinger M. D. , Forsthuber T. G.

Archivum Immunologiae et Therapiae Experimentalis

2004

tom 52

nr 6

Potential role of macrophage migration inhibitory factor in the pathogenesis of Marek’s disease

84%

Fan Z. , Wang H. , Pan J. , Yu S. , Xia W.

Journal of Veterinary Research

2020

tom 64

nr 1

Leukemia inhibitory factor inhibits the proliferation of primary rat astrocytes induced by oxygen-glucose deprivation

84%

Fan Y.-Y. , Zhang J.-M. , Wang H. , Liu X.-Y. , Yang F.-H.

Acta Neurobiologiae Experimentalis

2013

tom 73

nr 4

Leukemia inhibitory factor (LIF) is a neuroprotective cytokine that is necessary for the normal development of astrocytes. Oxygen-glucose deprivation (OGD) can induce astrocyte proliferation by increasing hypoxia-inducible factor alpha (HIF- 1a) and vascular endothelial growth factor (VEGF). Here, we studied whether LIF affects the proliferation of cultured primary rat astrocytes under OGD conditions by measuring EdU incorporation into astrocyte DNA and the expression of proliferating cell nuclear antigen (PCNA) mRNA and protein. Our findings show that low concentrations of LIF (5 and 10 ng/mL) significantly decreased EdU incorporation and downregulated the expression of PCNA mRNA and PCNA protein in astrocytes subjected to OGD. A low concentration of LIF (10 ng/mL) clearly inhibited astrocyte proliferation induced by OGD, while a higher concentration (50 ng/mL) had no effect. To investigate the mechanism of this inhibition by LIF (10 ng/ mL), the expression of 3 related genes (LIF receptor, HIF-1a, and VEGF) was assessed using real-time PCR; VEGF protein expression was measured by Western blot. Our results indicate that LIFR mRNA was downregulated in astrocytes subjected to OGD. Interestingly, treatment with LIF further reduced LIFR mRNA expression in these cells. LIF treatment also decreased the expression of HIF-1a mRNA, VEGF mRNA, and VEGF protein induced by OGD. Low concentrations of LIF were observed to inhibit astrocyte proliferation induced by OGD.

Differential effect of interleukin-1 on interleukin-6 stimulated alpha-1-antichymotrypsin expression in human hepatoma cell lines

84%

Rokita H. , Bartle L. , Sipe J. D.

Folia Histochemica et Cytobiologica

1992

tom 30

nr 4

Cell response to the stimulatory and inhibitory factors under the interaction with macrophages influenced by lipopolysaccharides [LPS] and dimerized lysosyme [DL]

84%

Lukaszyk A. , Klein P. , Gozdzicka-Jozefiak A. , Balcerek M. , Filipiak K. , Gorska-Rafinska L. , Ludwiczak H. , Butowska W. , Piescikowska I. , Sawinski P. , Stolzmann W. M.

Folia Histochemica et Cytobiologica. Supplement

1997

tom 35

nr 2

Regulation of the rat alpha 2 macroglobulin gene by interleukin 6 and leukemia inhibitory factor

67%

Hocke G. M. , Cui M. Z. , Ripperger J. A. , Fey G. H.

Folia Histochemica et Cytobiologica

1992

tom 30

nr 4

Role of alpha-1-microglobulin in immune response and inflammation

67%

Akerstrom B.

Folia Histochemica et Cytobiologica

1992

tom 30

nr 4