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1
Content available remote Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method
100%
Radomski J. , Słonimski P. , Zagórski-Ostoja W. , Borowicz P.
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nr 3
441-451
EN
Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics - allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.
2
Content available remote Antivirals - current trends in fighting influenza
100%
Król E. , Rychłowska M. , Szewczyk B.
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nr 3
495-504
EN
Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.
3
A universal flu vaccine
100%
Kesik-Brodacka M. , Plucienniczak G.
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tom 61
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nr 3
4
Content available remote Structural biology of the influenza virus fusion peptide
100%
Worch R.
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nr 3
421-426
EN
The release of influenza RNA inside the host cell occurs through the fusion of two membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by the influenza hemagglutinin protein (HA), in particular by the fusion peptide (HAfp) located in the N-terminal fragment of HA2 subunit. This protein fragment anchors in the internal endosomal membrane, whereas the C-terminal HA2 part comprises a transmembrane domain (TMD) embedded in the viral envelope. A drop of pH in the endosome acts as the main trigger for HA2 large conformational change that leads to anchoring of the fusion peptide, close contact of the membranes and the subsequent fusion. Throughout the years the major research effort was focused on a 20-aminoacid fragment (HAfp1-20), shown by NMR to adopt a 'boomerang'-like structure. However, recent studies showed that extending HAfp1-20 by three highly conserved residues W21-Y22-G23 leads to formation of a unique, tight helical hairpin structure. This review summarizes recently discovered structural aspects of influenza fusion peptides and their relations with the membrane fusion mechanism.
5
Influenza viruses resistant to neuraminidase inhibitors
100%
Nitsch-Osuch A. , Brydak L. B.
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tom 61
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nr 3
6
Structural biology of the influenza virus fusion peptide
100%
Worch R.
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tom 61
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nr 3
7
The role of target membrane sialic acid residues in the fusion activity of the influenza virus: the effect of two types of ganglioside on the kinetics of membrane merging
100%
Ramalho-Santos J. , Pedroso De Lima M. C.
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2004
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tom 09
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nr 2
EN
The influenza virus enters target cells via the action of hemagglutinin proteins (HA) inserted into the viral envelope. HA promotes membrane fusion between the viral envelope and endosomal membrane at low pH, following viral binding to sialic acid-containing receptors on target cells, and internalization by endocytosis. The effect of target membrane sialic acid residues on the fusion activity of the influenza virus towards model membranes was evaluated by both reduction, (i.e. treating somatic cells with neuraminidase- (NA-) prior to virus-cell interactions), and by supplementing liposomes with the gangliosides GD1a and GT1b. The harshness of the neuraminidase pretreatment of target cells required to affect virus-induced membrane merging was found to greatly depend on the assay conditions, i.e. whether a virus-cell prebinding step at neutral pH was included prior to acidification. Minor concentrations of neuraminidase were found to greatly reduce virus fusion, but only in the absence of a prebinding step; they had no effect if this step was included. Although membrane merging was greatly reduced following cell neuraminidase pretreatment, virus-cell association at low pH was not disturbed proportionately. This probably reflects unspecific virus-cell binding under these conditions, probably of inactivated or aggregated virus particles, which does not translate into membrane merging. This seems to suggest both that target membrane sialic acid can protect the virus from losing its activity before triggering membrane merging, and that the importance of this interaction is not merely to ensure virus-target proximity. With liposomes, we found that both types of ganglioside supported efficient fusion, with GD1a promoting a slightly faster initial rate. However, in this case, virus-target proximity closely mirrored fusion activity, thus pointing to differential specificity between targets routinely used to assay influenza virus fusion activity.
8
A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR
86%
Miarka M. , Horban A. , Maliszewska H. , Bilinski P. , Prus-Kowalczuk W.
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tom 61
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nr 3
9
Antiviral activity of novel oseltamivir derivatives against some influenza virus strains
86%
Kocik J. , Kolodziej M. , Joniec J. , Kwiatek M. , Bartoszcze M.
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tom 61
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nr 3
10
Antivirals - current trends in fighting influenza
86%
Krol E. , Rychlowska M. , Szewczyk B.
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tom 61
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nr 3
11
Detection of the influenza virus yesterday and now
86%
Wozniak-Kosek A. , Kempinska-Miroslawska B. , Hoser G.
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tom 61
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nr 3
12
Lactococcus lactis IBB477 presenting adhesive and mucoadhesive properties as a candidate carrier strain for oral vaccination against influenza virus
72%
Radziwill-Bienkowska J. M. , Zochowska D. , Bardowski J. , Mercier-Bonin M. , Kowalczyk M.
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tom 61
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nr 3
13
Content available Zakażenia wirusowe układu oddechowego w środowisku pracy służby zdrowia
72%
Roży A. , Jaguś P. , Chorostowska-Wynimko J.
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tom nr 4
27-29
PL
Infekcje wirusowe dróg oddechowych stanowią poważny problem zdrowotny i ekonomiczny na całym Świecie wysoka zakaźność tej grupy wirusów bezpośrednio wynika z łatwości transmisji, szczególnie w większych skupiskach ludzkich, takich jak placówki medyczne i oświatowe, duże zakłady pracy czy środki transportu. Ryzyko zakażenia dla tych grup zawodowych, a zwłaszcza pracowników ochrony zdrowia fest więc znacząco wyższe. Konieczne jest świadome stosowanie zasad profilaktyki czynnej (szczepienia ochronne), a w okresie wzrostu zapadalności również profilaktyki biernej (izolacja zakażonych, higiena). Niski poziom wyszczepialności przeciw grypie w populacji polskiej, w tym również wśród pracowników opieki zdrowotnej stanowi istotny problem, niosący znaczące ryzyko dla zdrowotności społeczeństwa i gospodarki kraju.
EN
Respiratory viral infections pose a significant health and economic burden all over the world. Due to their easy transmission. respiratory viruses are highly infective, particularly in the larger human groupings, such as medical and educational facilities, larger industrial units and public transportation. Therefore, respective professional groups are regarded as the high risk population In those groups, in particular in medical staff, the premeditated proactive flu prophylaxis by means of regular immunization is strongly advised. A secondary prophylaxis, the strict isolation of infected patients must be introduced in health care facilities during flu season or epidemic. The unexceptionally low flu vaccination rate in Poland, both in general population and medical staff is of particular concern as a potential serious treat for society's state of health but also country economy.
14
Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method
72%
Radomski J. P. , Slonimski P. P. , Zagorski-Ostoja W. , Borowicz P.
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tom 61
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nr 3
15
Evaluation of immunological status of horses against influenza virus based on the presence of antibodies against NS1 and M1 proteins
72%
Rozek W. , Polak M. P. , Zmudzinski J. F.
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nr 2
16
New approaches to the prevention and treatment of viral diseases
58%
Pronin A. V. , Narovlyansky A. N. , Sanin A. V.
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2021
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tom 69
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nr 1
17
Characterization of a novel transcript variant of human STAU1 gene
58%
Nie F. , Yao H. , Qi R. , Li X. , Wu C.
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2008
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tom 55
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nr 3
473-478
EN
Human STAU1 is one member of the family of double-stranded RNA (dsRNA)-binding proteins. It is thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1). Four transcripts coding two isoforms have been identified before. In this study, we have isolated a novel transcript of STAU1, coding a novel isoform that has six amino acids more (SFPLKQ) than isoform a. In order to examine the tissue distribution of this novel isoform, we have performed RT-PCR experiments and the analysis showed that it was highly expressed in heart, liver, kidney and pancreas.
18
Molecular methods for the detection of avian influenza type A viruses
58%
Domanska-Blicharz K. , Smietanka K. , Minta Z.
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nr 3
19
Characteristic of humoral response of elderly to inactivated influenza vaccine
58%
Siennicka J.
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nr 5-6
20
Influenza: problem in Poland as elsewhere
58%
Magdzik W. , Brydak L. B.
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nr 5-6
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