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EN
There are higher requirements for microstructures and high-precision components in microelectronics, photonics, sensors, optoelectronics and medical devices. For changing the traditional manufacturing methods with cumbersome process and complex equipment, researchers put forward a laser shock forming technique which can contribute to the metal forming with high precision and efficiency in recent years. So far, the laser shock forming needed high pulse energy and high energy. In this paper, nanosecond laser with high frequency and low pulse energy was adopted to make possible the aluminum foil forming on the copper micro-molds with different sizes and shapes. The deformations of aluminum foil were measured by SEM, optical profiler and AFM. Also, the deformation laws were analyzed by comparing imprinting results under different micro-molds. Lastly, stress distribution and deformation process of aluminum foil was investigated by numerical simulations.
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Content available Seksualność a⁠ przywiązanie
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EN
This publication refers to the J. Bowlby’s attachment theory. This theory says that in human there is a⁠ biologically conditioned tendency to search and create proximity to significant persons. Followers of Bowlby – C. Hazan i⁠ P. Shaver considered romantic relation as an attachment relation. They have found that both in child-parent and romantic relation the same biological system is responsible for emotional and behavioral evolution of relation. The base of attachment is emotional and psychical proximity. In this work it is emphasized how important for creation of attachment in romantic relation first sexual contacts are. It is also underlined that breaking romantic or child-mother relation may provoke serious traumatism. The author of the publication claims that among factors influencing proximity in sexual relation are: emotional proximity, sex (stronger impact in case of women), earlier effort to abstain from this relation (eg. religiously motivated), whether the partner is or is not the first one (stronger impact in case of the first sexual partner).
EN
Genomic imprinting is a normal process causing genes to be expressed from only one of the two parental chromosome homologues according to their parental origin. Imprinted genes function in a range of developmental processes. In recent years, data has emerged indicating discordance of imprinting between mouse and man, polymorphic imprinting between different individuals and tissue-specific imprinting within individuals. This suggests that imprinting might be an adaptable and dynamic process with the potential to act as a mechanism regulating gene dosage in different developmental contexts. Delta-like homologue 1 (Dlk1) is a paternally expressed imprinted gene that encodes both a transmembrane protein and a secreted isoform generated by alternative splicing, and is an atypical member of the Notch/Delta/Serrate family of developmental signalling molecules. Although widely expressed during embryonic development, only a few tissues including neurogenic regions of the brain retain Dlk1 expression in adults. Analysis of neurogenesis in the SVZ of Dlk1 mutant mice shows a reduction in the numbers of stem cells in vivo and an impairment of newborn neurons incorporated into the olfactory bulb as well as fewer primary neurospheres in vitro suggesting that normal levels of Dlk1 are necessary for the life-long maintenance of neural stem cells (NSCs). Within the SVZ, DLK1 is a niche factor secreted by astrocytes and that membrane-bound DLK1 is required in NSCs to respond to it. In contrast to the neighbouring Gtl2 gene, we observe specific absence of Dlk1 imprinting in the stem cell and astrocyte populations in the SVZ niche indicating that the mechanism conferring biallelic expression can override the imprint selectively at Dlk1 to control normal neurogenesis in the adult brain. This neurogenic requirement for both the maternally and paternally expressed alleles of the canonically imprinted Dlk1 gene supports the hypothesis that control of gene dosage by absence of imprinting is an important developmental process. We are testing the hypothesis that other imprinted genes important in neurogenesis may also modulate imprinting to control gene dosage.
PL
Autor, podając przykłady ze świata zwierząt i analizując domniemane świadectwa istnienia istot pozaziemskich, dowodzi, że teoria inteligentnego projektu nie jest odrzucana współcześnie przez wzgląd na światopoglądowe uprzedzenia społeczności naukowców (jak twierdzą zwolennicy tej teorii), lecz dlatego, że istnieją przekonujące wyjaśnienia alternatywne.
EN
Invoking examples from the animal world and analyzing purported evidence of existence of extraterrestrials, author argues that intelligent design theory is not presently rejected because of the scientific community prejudices (as proponents of this theory claim), but because there exist plausible alternative explanations.
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