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3 Cellular and Molecular Biology Letters

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Use of the post-insertion method for the formation of ligand-coupled liposomes

100%

Allen T. M. , Sapra P. , Moase E.

Cellular and Molecular Biology Letters

2002

tom 07

nr 3

A new technique is described for the formation of ligand-targeted liposomes that can be used with whole antibodies, antibody fragments, peptides or other ligands. The ligands are coupled to polyethylene glycol micelles and then transferred in a simple incubation step from the micelles into the outer monolayer of pre-formed, drug-loaded liposomes, This versatile method allows a combinatorial approach to the design of targeted liposomes that minimises manufacturing complexities, allowing a variety of ligands to be inserted into a variety of pre-formed liposomes containing a variety of drugs. This allows the ligand-targeted therapeutics to be tailored to the needs of individual patients.

ATP-loaded liposomes and immunoliposomes protect ischemic myocardium in isolated rat hearts and in rabbits with experimental myocardial infarction

100%

Torchilin V. P. , Verma D. D. , Levchenko T. S. , Hartner W. C. , Bernstein E. A.

Cellular and Molecular Biology Letters

2005

tom 10

nr Suppl.

Immunoliposomes for the simultaneous targeted inhibition of angiogenesis and tumor growth

100%

Marty C. , Ballmer-Hofer K. , Neri D. , Klemenz R. , Schwendener R. A.

Cellular and Molecular Biology Letters

1999

tom 04

nr 2