Wyniki wyszukiwania - Biblioteka Nauki

1

The influence of saturated fatty acids on human lung epithelial cells

100%

Reczyńska K. , Pamuła E. , Chrzanowski W.

Engineering of Biomaterials

|

2017

|

tom Vol. 20, no. 143 spec. iss.

55

2

On the metabolism of prostaglandin E1 administered intravenously to human volunteers

75%

Peskar B. A. , Cawello W. , Rogatti W. , Rudofsky G.

Journal of Physiology and Pharmacology

|

1991

|

tom 42

|

nr 3

EN

We have demonstrated recently the formation of a biologically active metabolite of prostaglandin (PG) E₁, 13,14-dihydro-PGE₁, during intravenous infusions of PGE₁ in patients with peripheral arterial occlusive disease. We have now investigated the levels of the immediate precursor of 13,14-dihydro-PGE₁ , the biologically inactive 15-keto-13,14-dihydro-PGE₁, during intravenous administration of 20 pig, 40pig or 80 pig PGE₁ over a period of 60 min to human volunteers. It was found that levels of 15-keto-13,14- -dihydro-PGE₁, but not those of PGEx itself, increased in a dose-dependent manner. Thus, increased formation of 13,14-dihydro-PGE₁ from 15-keto- 13,14-dihydro-PGE₁ with increasing doses of PGE₁ can be expected to occur. It remains to be investigated, to which extent formation of small amounts of 13,14-dihydro-PGE₁ during intravenous infusion of PGE₁ could contribute to the therapeutic effects of PGE₁ in patients with peripheral arterial occlusive disease.

3

Venous pattern of the left apical bronchopulmonary segment (S6) of the human lower lobe

75%

Topol M.

Folia Morphologica

|

1986

|

tom 45

|

nr 3

4

75%

Topol M.

Folia Morphologica

|

1998

|

tom 57

|

nr 3

5

Venous drainage of the middle lobe of the right lung in man

75%

Ryba S. , Topol M.

Folia Morphologica

|

2004

|

tom 63

|

nr 3

EN

The shape of the middle lobe of the right lung may vary greatly because of the varying extent of its surfaces in different specimens and the profuse branching of the two segmental bronchi, arteries and veins. The architecture of the middle lobe is therefore especially difficult to understand. For these reasons, attention must be paid to the arrangements of the veins which separate its segments. Thus, the aim of this study was to investigate the ways in which venous drainage of the middle lobe segments may take place. The studies were performed on 40 organs taken from adult human cadavers of both sexes. The pulmonary vessels and bronchi were filled with Plastogen G, after which corrosion casts were made and skeletonised. The lateral segment (SIV) and the medial segment (SV) of the middle lobe were drained in 55% of specimens by one vein and in 35% of specimens by two separately terminated veins. Considerably less frequently there were 3 veins (7.5% of specimens) and only in 2.5% of specimens — 4 veins. In specimens where the middle lobe was drained by one vein (55%) it was formed by joining the lateral (V4) and the medial (V5) segmental veins. In 32.5% of specimens these two segmental veins were formed by a junction of their typical sub-segmental tributaries, where the posterior sub-segmental vein V4a and the superior sub-segmental vein V5a were intra-segmental veins, whereas the anterior sub-segmental vein V4b and the inferior sub-segmental vein V5b were inter-segmental veins. In the remaining 22.5% of specimens with one vein of the middle lobe we noticed modifications in the course of the bronchi, arteries and veins. In the middle lobes drained by two separate veins (35% of specimens) there were independently running segmental veins, V4 and V5. These were formed by their typical tributaries (15%), whereas in the remaining 20% of specimens there were unusual patterns. Three individual veins of the middle lobe (7.5% of specimens) accompanied the lateral-medial type of bronchial arrangement in 5% of specimens, while in 2.5% of specimens the bronchial pattern was of the superior-inferior type. These veins run so as to form more often two superior and one inferior vein. The venous pattern of the middle lobe was consistent with the bronchial and arterial patterns in 35% of specimens. However, this conformation was present in those organs (32.5% of specimens) where the middle lobe was drained by one vein and only in 2.5% of specimens if there were two veins. If 3 or 4 individually emptied veins were present, we could not find any organ in which the bronchial, arterial and venous pattern would be fully compatible. Thus, the research revealed that convenient conditions for the separation of the segments of the middle lobe of the right lung were present in approximately 1/3 of the middle lobes.

6

Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells

63%

Ma Z. , Dong A. , Kong M. , Qian J.

|

tom 12

|

nr 4

556-572

EN

The type 1 insulin-like growth factor receptor (IGF-1R), which is over-expressed or activated in many human cancers, including lung cancer, mediates cancer cell proliferation and metastasis. Several studies indicate that blocking IGF-1R expression can inhibit tumor cell proliferation and metastasis. In this study, inhibition of the endogenous IGF-1R by recombinant adenoviruses encoding short hairpin RNAs against IGF-1R was found to significantly suppress IGF-1R expression, arrest the cell cycle, enhance the apoptotic response, and inhibit proliferation, adhesion, invasion and migration in A549 cells. Moreover, silencing IGF-1R decreases the expression of invasive-related genes including matrix metalloproteinase-2 (MMP-2), MMP-9, and urokinase-plasminogen activator (u-PA), and the phosphorylation of Akt and ERK1/2. These results suggest that the silencing of IGF-1R has the potential to be an effective cancer gene therapy strategy for human lung cancer.

7

Influence of air-ions on people subjected to physical effort and at rest

63%

Wiszniewski A. , Suchanowski A.

|

tom 17

|

nr 5

801-810

EN

This work analyzes the influence of air-ions of different types and concentrations on people subjected to physical effort and at rest. The outcome of the conducted research indicates that air-ions at a concentration level of 7.5 million ions/cm³ decrease the consumption of O₂ by around 20%, and release CO₂. Furthermore, the positive air-ions shorten the period necessary to achieve the anaerobic change threshold by almost 70%, at a high significance ratio of 0.001. A secondary research outcome also shows that the change of these physiological indicators probably results from the permeation of ionized molecules to the lower parts of human lungs.

8

Cigarette smoke extract influences intracellular calcium concentration in A549 cells

63%

Yoo Y.-M. , Jung E.-M. , Jeon B.-H. , Tran D. N. , Jeung E.-B.

Journal of Physiology and Pharmacology

|

2020

|

tom 71

|

nr 5

9

Application of short-term tests in assessment of atmospheric air pollution

38%

Piekarska K. , Zaciera M. , Czarny A. , Zaczyńska E.

Environment Protection Engineering

|

2011

|

tom Vol. 37, nr 2

85-98

EN

Results of analyses of airborne particulates collected in winter and summer seasons from two locations of Wroclaw (city centre and the outskirts area) have been presented. Samples of particulate matter were collected on sintered-glass filters, using a high performance air aspirator Staplex-PMIO. Extraction with dichloromethane was carried out in a Soxhlet apparatus. Mutagenicity of dichloromethane extracts was studied based on a conventional Salmonella assay. Two Salmonella typhimurium strains TA98 and YG1041 were employed in the assay. Genotoxicity of organic air pollutants was detected using a miniaturized SOS chromotest obtained from EBPI (Brampton, Ontario, Canada). Bacterial assays were carried out with and without metabolic activation by the S9 microsomal fraction. Cytotoxicity of the particulate extracts was studied by the method of their direct contact with onelayer culture of human lung carcinoma epithelial cells - A549.