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Zakażenia szpitalne - nierozwiązany problem w lecznictwie zamkniętym

100%

Wasilewski P.

Kontrola Państwowa

2018

tom 63

nr 6 (383)

75-88

Hospital infections result in complications of the original disease, which frequently leads to disabilities or even to death. They also pose a problem for the very medical entities, due to prolonged stays in hospitals and increased costs of the services provided. Therefore, the Supreme Audit Office decided to conduct the first planned coordinated audit in the area. The audit seems to be especially important in the context of increased drug resistance of micro-organisms, which do not react to the available antibiotics, and the growing number of patients infected with pathogens resistant to many drugs, being very difficult to eliminate from hospitals.

In vitro activity of caspofungin against planktonic and sessile Candida sp. cells

100%

Serefko A. , Chudzik B. , Malm A.

Polish Journal of Microbiology

2006

tom 55

nr 2

Candida sp. may be regarded as one of the leading etiologic agents of hospital-acquired infections, including those related with the indwelling medical devices, which become colonized by the yeasts, accompanied by biofilm formation. In this paper we assayed in vitro susceptibility to caspofungin of planktonic and sessile cells of nasopharyngeal isolates of Candida sp. Two types of biomaterials were used - silicone elastomer-coated latex urinary Foley catheter and PCV Thorax catheter. The minimal inhibitory concentrations (MIC) of caspofungin for planktonic Candida sp. cells ranged from 0.008 to 0.031 mg/l, while the minimal fungicidal concentrations (MFC) from 0.008 to 0.062 mg/l, with MFC/MIC ratios ≤2. The minimal concentration of caspofungin preventing adhesion process of Candida sp. on both biomaterials ranged from 0.004 to 0.031 mg/l, while preventing biofilm formation from 0.004 to 0.062 mg/l. In contrast, much higher minimal concentrations of caspofungin were needed to eradicate the mature biofilm (0.25 to >8 mg/l). In all cases, drug concentrations depended on the strain and the biomaterial used. Our preliminary data suggest that caspofungin, showing good anti-adherent activity in vitro against Candida sp., appears to be a potential agent rather for prophylaxis of the yeast infections associated with biomaterials but not for their treatment.

BOX-PCR is an adequate tool for typing of clinical Pseudomonas aeruginosa isolates

67%

Wolska K. , Kot B. , Jakubczak A. , Rymuza K.

Folia Histochemica et Cytobiologica

2011

tom 49

nr 4