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Medicinal and cosmetic products used in treatment of hair loss

100%

Abramek N. , Naja-Wiśniewska M. , Nieradko-Iwanicka B.

Polish Hyperbaric Research

2022

tom nr 3(80)

73--88

Hair loss or alopecia is a reduction in the volume or complete loss of hair and is a fairly common clinical problem, especially in the geriatric population. Androgenetic alopecia (AGA) is the most common type of hair loss in men. Androgenetic alopecia in women most often occurs before the age of 60. We also distinguish androgenetic alopecia in postmenopausal women and scarring, areata, telogen and drug-induced alopecia. The aim of the study was to analyze the composition of medicinal and cosmetic preparations available on the Polish market, recommended for people struggling with alopecia. In 2022, the composition of preparations used in alopecia available in pharmacies and drugstores was analyzed. In total 57 medicinal and cosmetic preparations recommended for people suffering from alopecia have been identified. The most common active substance in the analyzed preparations is finasteride. Frequently used active substances are biotin and minoxidil, rarely prednisolone. Conclusions: 1. In preparations intended for people with alopecia, the most frequently used active substance is finasteride. 2. Statistically, preparations for hair loss are most often in the form of tablets and shampoos. 3. The analyzed preparations for alopecia belong to the category of prescription drugs and cosmetics, less often in the category of OTC drugs or dietary supplements.

Splenic melanosis during normal murine C57BL/6 hair cycle and after chemotherapy

51%

Michalczyk-Wetula D. , Salwinski A. , Popik M. , Jakubowska M. , Plonka P. M.

Acta Biochimica Polonica

2013

tom 60

nr 3

Cancer chemotherapy is associated with serious side effects, including temporary hair loss and impairment of pigmentation. We suspect that ectopic melanin deposition occurring due to chemotherapy may add to these effects worsening the already unpleasant symptoms. We associated the ectopic occurrence of follicular melanin after chemotherapy with splenic melanosis - an interesting example of extradermal melanin localization - and we expected an increase in splenic melanin deposition after chemotherapy. Using the C57BL/6 murine model of synchronized hair cycle induced by depilation, we visualized splenic melanin by means of several histological and histochemical protocols of staining: hematoxylin and eosin, May-Grünwald-Giemsa and Fontana-Masson. Unexpectedly, the splenic deposition of melanin decreased due to application of cyclophosphamide (i.p. 120 mg/ kg body weight on day 9 post depilation). The drop was abrupt and lasted for at least 5 days (day 13-18 post depilation), as compared with normal hair cycle. Moreover, in mice with normal, depilation-induced hair cycle we observed a similar drop shortly before entering catagen (day 15 post depilation), followed by a slow and partial increase in splenic melanization up to day 27 post depilation in both groups. We conclude that cyclophosphamide negatively affects splenic melanization and/or extradermal transfer of ectopic melanin from the dystrophic hair follicles, but the most powerful down-regulator of splenic melanosis is normal and dystrophic catagen - the phase of hair follicle involution and re-modelling.

The expression of the renin-angiotensin-aldosterone system in the skin and its effects on skin physiology and pathophysiology

51%

Aleksiejczuk M. , Gromotowicz-Poplawska A. , Marcinczyk N. , Przylipiak A. , Chabielska E.

tom 70

nr 3

Herbs in treatment of the hairy skin of the head

51%

Linkowska M. , matlawska I.

Herba Polonica

2007

tom 53

nr 2