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Into the unknown - the death pathways in the neonatal gut epithelium

100%

Godlewski M. M. , Slupecka M. , Wolinski J. , Skrzypek T. , Skrzypek H. , Motyl T. , Zabielski R.

Journal of Physiology and Pharmacology. Supplement

2005

tom 56

nr 3

7-24

Apoptosis is a fundamental process in the development of the fast growing intestinal mucosa. Apoptotic cells are present along the whole length of the villi and in the crypts. The mechanisms involved in the induction of apoptosis in the gut mucosa are still unknown. Cytokines are believed to play a role in auto- and paracrine models because the cells are dying in so-called "packets" containing neighboring cells. In the rapidly developing gut of neonates, the apoptosis rate is transiently reduced in the first days of life, enhancing the growth of mucosa. Afterwards, apoptosis plays a role in the exchange of the enterocyte population, facilitating maturation of the mucosa. The presence of autophagic cells has been confirmed for the first time in the developing gut. Deprivation of growth factors during feeding artificial milk formula led to an increased apoptosis rate. Supplementation with leptin reduced cell apoptosis and increased the mitosis-to-apoptosis ratio. Autophagy was also diminished. The key to healthy gut mucosa growth in early life, especially in fast-growing animals, is colostrum, which supplies nutritional and defensive components together with supplementary growth factors, cytokines and hormones essential for growth and maturation of gut mucosa.

Molecular mechanism of programmed cell death in the gut epithelium of neonatal piglets

80%

Godlewski M. M. , Hallay N. , Bierla J. B. , Zabielski R.

Journal of Physiology and Pharmacology. Supplement

2007

tom 58

nr 3

97-113

Intestinal MMC-related electric fields and pancreatic juice control the adhesion of gram-positive and gram-negative bacteria to the gut epithelium - in vitro study

80%

Jankowska A. , Wrzesinski M. , Laubitz D. , Kazimierczak W. , Skrzypek H. , Bardowski J. , Zabielski R. , Grzesiuk E.

Journal of Physiology and Pharmacology

2008

tom 59

nr 4

795-810

The adhesion of six different Lactobacillus and Lactococcus and three pathogenic Escherichia and Salmonella strains was studied using Caco-2 cell line. In this in vitro model system the influence of weak electric field (EF) on bacterial adhesion was tested. The EF source was the in vitro reconstruction of spiking potentials recorded in the duodenum of a healthy calf during one myoelectrical migration complex (MMC) cycle. The ability to adhere to Caco-2 cells of bacteria belonging to two groups, Gram-positive lactobacilli and lactococci, and Gram-negative Escherichia and Salmonella differed considerably. The pathogenic bacteria adhered better to well-differentiated Caco-2 cells whereas lactobacilli and lactococci displayed better adhesion to non-differentiated Caco-2 cells. In the presence of MMC-related EF an increased adhesion of Lactobacillus and Lactococcus but not of Salmonella enterica s. Enteritidis and E. coli 269 to Caco-2 cells was observed. Two later strains adhered even less in the presence of EF. The same tendency was found in the presence of pancreatic juice in a cell medium. In conclusion, the myoelectric component of the small intestinal motility, the MMC-related EF, and pancreatic juice may increase the ability of lactic acid bacteria to adhere to GI epithelial cells, creating better environmental conditions for colonization of the intestine and competition with Gram-negative pathogens.

Potassium ion transporting ATPase activities in insect cells: elektrophysiology, biochemistry and molecular biology

60%

Djamgoz M. B. A. , Billingsley P. F. , Emery A. M. , Fitzgerald E. M. , MacVicker J. A. K. , Pickard B. , Ready P. D.

Biophysics of Membrane Transport

1992

tom 11

nr 1