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1 Polish Journal of Veterinary Sciences

1 2000

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Monitoring of selected immunological parameters in bitches with glandular cystic hyperplasia - pyometra complex before and after ovariohysterectomy

100%

Mojzisova J. , Valocky I. , Maracek I.

2000

tom 03

nr 1

The aim of the study was to determine the degree of phagocytic activity of neutrophils, lymphocyte histogenesis and total immunoglobulin level in six bitches with glandular cystic hyperplasia - pyometra complex (GCH - PC) before and after ovariohysterectomy in comparison to healthy dogs. Haematological study showed significant increases (P<0.005) in the white blood cell count and neutrophilia. After ovariohysterectomy these parameters gradually returned to normal. The phagocytic ability (expressed as phagocytic activity PA and index of phagocytic activity IPA) of neutrophils was impaired in bitches wit GCH - PC and has improved during the therapy. The degree of concanavalin A induced lymphocyte blastogenesis expressed as a stimulation index was significantly (P<0.005) depressed in affected bitches and after surgical treatment had not reached values comparable with that found in healthy dogs. The level of total immunoglobulins was significantly (P<0.05) decreased at the beginning of observation and gradually increased after treatment. The results of the present study have provided usuful information for diagnosis and prognosis of GCH - PC in bitches because the success of the treatment and recovery from the GCH - PC is in direct relation with the optimal condition of the immune system.