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1 Cellular and Molecular Biology Letters

1 2000

1 Recillas-Targa F.

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The chicken alpha- and beta-globin gene domains and their chromatin organization

100%

Recillas-Targa F.

2000

tom 05

nr 4

451-467

The eukaryotic genome is organized into discrete chromatin domains. The globin groups of genes have been two of the classical biological systems to study the relationship between gene regulation and chromatin structure during development. The individual promoters, enhancers and silencers of the globin genes are stage- and tissue-specific regulatory elements that are controlled by the interaction of ubiquitous and erythroid nuclear factors. Such regulated activation requires an optimal chromatin organization. Erythroid and constitutive DNase I hypersensitive sites (DHs) contribute to chromatin domain remodeling mediated by locus control region (LCR) activity and defined by domain boundaries. A comparative analysis of the chicken α-and β-globin domains will outline the relevance and effect of chromatin structure on gene regulation.