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1 Progress on Chemistry and Application of Chitin and its Derivatives

1 2022

1 Małolepsza-Jarmołowska K.

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INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

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Małolepsza-Jarmołowska K.

Progress on Chemistry and Application of Chitin and its Derivatives

2022

tom 27

183-193

Gastro-oesophageal reflux disease is a serious social problem that affects every sphere of life. The quality of life of people with this disease is reduced due to the presence of troublesome symptoms, which translates into reduced work efficiency and vitality. The major problem is acidic gastro-oesophageal reflux. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and carboxymethylcellulose sodium salt on the protective properties of prepared gels in the treatment of acid reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. Preparations containing 0.3% carboxymethylcellulose sodium salt showed the highest pH. The texture tests showed the effect of carboxymethylcellulose sodium salt concentration on the adhesion work of the tested gels. These gels could be used in the treatment of advanced acid reflux.