Wyniki wyszukiwania - Biblioteka Nauki

1

Gastrointestinal Bleeding in Patients with Acute Surgical Diseases

100%

Winiarski M. , Matłok M. , Biesiada Z. , Bolt L. , Woźniak M. , Merak A.

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2009

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tom 81

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nr 12

603-608

EN

The aim of the study was to analyse patients in whom upper gastroinentestinal bleeding appeared during hospitalization in the surgical clinic.Material and methods. The study group consisted on 61 patients. 35 were women and 26 were men. The mean age of women was 76 and men 64.8 years. The mean age of the whole group was 72.3 years. 30 patients (49%) were hospitalized in general surgery ward, 16 (26%) in trauma unit and 15 patients (25%) in intensive care unit.Results. The reasons of hospitalisation in general surgery ward were: acute cholecystitis, acute pancrtatitis, peritonitis, lower extremity ischemia with foot necrosis, large bowel cancer and cancer of the gall-bladder. Patients were admitted to trauma unit because of hip and pelvic fractures. Patients were hospitalized in intensive care unit because of polytrauma, diffuse peritonitis, isolated head trauma and necrotising pancreatitis. The main source of bleeding were duodenal and gastric ulcers. It appeared in 28 (45.9%) and 18 (29.5%) patients respectively. The other reasons of bleeding were: erosive gastritis (9 patients) and Mallory-Weiss syndrome (6 patients). Bleeding recurrence was found in 21 patients (34.4%). This group of patients was characterised by high mortality rate 43%. The highest was among patients in intensive care unit. It reached 60%.Conclusions. Based on the performed analysis we come to the following conclusions: 1. Upper gastrointestinal bleeding is serious complication during hospitalisation in surgical clinic; 2. Usually it affects older patients; 3. This complication is associated with high rate of rebleeding and high mortality rate.

2

Formation of new blood vessels during gastric ulcer healing. Role of bone marrow derived endothelial progenitor cells

86%

Ahluwalia A. , Brzozowski T. , Jones M. K. , Ichikawa Y. , Tarnawski A. S.

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nr 4

3

Gastric and duodenal ulcer and concomitant diseases among rural population

86%

Schabowski J. P.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

4

Interleukin-1 and experimental gastric ulcer healing in the rat

86%

Schuerer-Maly C. C. , Emmenegger U. , Ott K. , Flogerzi B. , Halter F.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 1

5

Non-variceal upper gastrointestinal bleeding-guidelines on management

86%

Celinski K. , Cichoz-Lach H. , Madro A. , Slomka M. , Kasztelan-Szczerbinska B. , Dworzanski T.

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nr 2

EN

In gastroenterology non-variceal upper gastrointestinal bleeding is health hazard. Frequency of occurrence accounts for 40-150 cases per 100000 inhabitants with death rate of 7-14%. Researches which goal is to improve treatment effectiveness as well as to establish standardized procedures for managing patients with symptoms of non-variceal upper gastrointestinal bleeding; have been conducted since many years. At the moment of admission, designed standards enable appropriate elaboration of patients’ health state, referral to the right clinic and implementation of the most accurate treatment methods. Increase of suppression of primary bleeding as well as prevention of recurrence is associated with dynamic development of endoscopic treatment methods as well as with optimization of pharmacological treatment. In significant percentage, efficiency of non – variceal bleedings treatment depends on clinic’s character (availability of equipment, experience of personnel) and on cooperation between several specialists (including gastroenterologist, surgeon, anesthetist, operative radiologist). Aim of the work is to present the latest evaluation of the mentioned subject, based on accessible literature. This work includes the basic principles for determination of bleeding intensity and risk of its recurrence as well as directions referring to fluids resuscitation and to monitoring of patients. Information on currently applied endoscopic methods for inhibition of non variceal upper gastrointestinal bleeding (injection, mechanical and thermo-coagulation techniques), comparison of their efficiency and possibility of application is provided in the work. The paper work also presents the newest directives for pharmacological treatment and guidelines for possible surgical treatment.

6

Influence of the stimulation of central chemoreceptors on the gastric mucosal blood flow in artificially ventilated and spontaneously breathing rats

86%

Sinski M. , Kowalczyk P. , Stolarczyk A. , Sawionek L. , Przybylski J.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 4

EN

Respiratory failure coincides frequently with the occurrence of gastric ulceration. In advanced respiratory insufficiency hypoxemia is often accompanied by hypercapnia, which is the stimulus for central chemoreceptors as well as for carotid body chemoreceptors. The purpose of the work was to investigate the reflex effect of stimulation of central chemoreceptors on gastric mucosal blood flow (GMBF) in the rat. Central chemoreceptors were stimulated by a gas mixture composed of 10% carbon dioxide, 50% oxide and 40% nitrogen. In artificially ventilated and spontaneously breathing animals, the stimulation of central chemoreceptors caused a significant increase in gastric mucosal vascular resistance, accompanied by a marked decline in blood flow. We hypothesize that in patients with respiratory insufficiency accompanied by hypercapnia, the reflex impairment of GMBF may contribute to gastric ulceration.

7

Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats

86%

Ogihara Y. , Okabe S.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 2

8

Mucosal adenosine deaminase activity and stump ulcer healing

86%

Namiot Z. , Namiot A. , Stasiewicz J. , Marcinkiewicz M. , Jaroszewicz W. , Gorski J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 2

9

A mutein of human basic fibroblast growth factor TGP-580 accelerates colonic ulcer healing by stimulating angiogenesis in the ulcer bed in rats

72%

Satoh H. , Szabo S.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 5

10

Involvement of cyclooxygenase-1 and cyclooxygenase-2 activity in the therapeutic effect of ghrelin in the course of ethanol-induced gastric ulcers in rats

72%

Warzecha Z. , Ceranowicz P. , Dembinski M. , Cieszkowski J. , Ginter G. , Ptak-Belowska A. , Dembinski A.

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nr 1

11

Pierwotny chłoniak wątroby powikłany perforacją przewodu pokarmowego u chorej z aktywną infekcją SARS-CoV-2

72%

Kisiel A. , Wojnarowicz A. , Komorowski A. L.

Państwo i Społeczeństwo

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2021

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nr 1

179-183

EN

Primary hepatic lymphoma is a rare occurrence as the liver is typically the location of lymphoproliferative diseases in their advanced stages. Usually the diagnosis is made late due to the lack of characteristic symptoms, but in some cases co-existing diseases may guide us to the diagnosis. We report the case of a 70- year-old patient in whom primary hepatic lymphoma was recently diagnosed and surgery for gastric ulcer perforation had to be performed in the presence of a concurrent active SARS-CoV-2 infection.

PL

Pierwotny chłoniak wątroby jest rzadką chorobą nowotworową ustępującą znacznie częstotliwością występowania wtórnym zmianom w przebiegu chorób limfoproliferacyjnych. Rozpoznanie jest zazwyczaj stawiane późno z powodu braku charakterystycznych objawów. W niektórych przypadkach objawy chorób współistniejących mogą pomóc w ustaleniu rozpoznania. W artykule przedstawiono przypadek 70-letniej chorej ze świeżo rozpoznanym chłoniakiem wątroby zakwalifikowanej do pilnej operacji ze względu na perforację wrzodu żołądka w przebiegu aktywnego zakażenia wirusem SARS-CoV-2.

12

Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats

72%

Tsukimi Y. , Nakai H. , Itoh S. , Amagase K. , Okabe S.

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2001

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tom 52

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nr 3

13

Multicenter evaluation of dual-therapy [omeprazole and amoxicillin] for Helicobacter pylori-associated duodenal and gastric ulcer [two years of the observation]

72%

Gabryelewicz A. , Laszewicz W. , Dzieniszewski J. , Ciok J. , Marlicz K. , Bielicki D. , Popiela T. , Knapik Z. , Poniewierka E.

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tom 48

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nr 1

14

Peptic ulcer among Polish rural population and the nicotinic index

72%

Schabowski J.

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2000

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tom 07

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nr 2

15

Effect of local injection with basic fibroblast growth factor (BFGF) and neutralizing antibody to BFGF on gastric ulcer healing, gastric secretion, angiogenesis and gastric blood flow

72%

Ernst H. , Konturek P. C. , Hahn E. G. , Stosiek H. P. , Brzozowski T. , Konturek S. J.

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2001

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tom 52

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nr 3

16

Role of p38 mitogen-activated protein kinase in the healing of gastric ulcers in rats

72%

Kabayashi N. , Kataoka T. , Ono A. , Tsukimi Y. , Okabe S.

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2001

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tom 52

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nr 2

17

Tryptophan free diet delays healing of chronic gastric ulcers in rat

72%

Konturek P. C. , Burnat G. , Brzozowski T. , Zopf Y. , Konturek S. J.

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nr 2

EN

Melatonin (MT) is an ubiquitous molecule, representing one of the phylogenetically oldest signaling mechanisms. Our previous studies demonstrated that MT and its precursor L-tryptophan (L-Trp) show strong protective effect on gastric mucosa. The aim of the present study was: 1) to assess the effect of MT and L-Trp on healing of chronic gastric ulcer and accompanying changes in gastric mucosal blood flow (GBF); 2) to study the effect of MT and L-Trp on expression of iNOS. cNOS and HSP70 in ulcerated mucosa; 3) to compare the effect of L-Trp free and L-Trp rich diet on ulcer healing and gene expression of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-), superoxide dismutase (SOD), cyclooxygenase-2 (COX-2) and NFkappaB-p65 protein expression in ulcer area and intact non-ulcerated. Chronic ulcers were induced in Wistar rats by Okabe’s modification of acetic acid method. Rats with chronic gastric ulcers were divided in following treatment groups: 1) vehicle (saline); 2) MT (20mg/kg-d i.p.) and 3) L-Trp (100 mg/kg i.p.). The expression of iNOS, cNOS and HSP70 protein was measured by Western blot. In separate experiments, the influence of commercially available (Bio-Serv, USA) L-Trp free diet (TFD) was compared to the L-Trp rich diet (TRD) on the course of ulcer healing was assessed. The ulcer area was measured by planimetry. The expression of TNF, COX-2 and SOD mRNA in ulcerated mucosa was analyzed by RT-PCR method. MT and its precursor L-Trp significantly accelerated ulcer healing. Healing ulcerated mucosa showed increased protein expression of iNOS and HSP70 as compared to intact gastric mucosa. TFD in contrast to normal diet significantly attenuated the ulcer healing, whereas the TRD exerted opposite effects and significantly accelerated ulcer healing. This last effect was accompanied by significant decrease of TNF- mRNA expression and expression of NFkB-p65 in gastric mucosa. We conclude that: 1) MT and its precursor L-Trp significantly accelerate healing of gastric ulcer; 2) L-Trp free diet significantly attenuates experimental ulcer healing and this is due to decreased synthesis of MT from L-Trp by EE cells in gastric mucosa and 3) MT shows strong anti-inflammatory effects due to inhibition of NFkappaB and TNF- expression.

18

The role of reactive oxygen species and capsaicin-sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress

72%

Kwiecien S. , Brzozowski T. , Konturek P. C. , Pawlik M. W. , Pawlik W. W. , Kwiecien N. , Konturek S. J.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 3

EN

Gastric microcirculation plays an important role in the maintenance of the gastric mucosal barrier and mucosal integrity. Sensory nerves are involved in the regulation of mucosal blood circulation and mucosal defense. Therefore, the ablation of these nerves by neurotoxic doses of capsaicin provides the possibility of determination of their role in gastric mucosal integrity. Stress ulceration represents a serious gastric lesions. Results of our previous experiments have indicated that water immersion and restraint stress (WRS) led to increased oxidative metabolism. Ablation of sensory nerves by high doses of capsaicin retards healing of gastric ulcers, but the role of reactive oxygen species (ROS) in the healing process has been little studied. Therefore, the aim of our present investigations was to determine the participation of ROS in sensory nerve activity during WRS. Experiments were caried out on 90 male Wistar rats and the area of gastric lesions was measured by planimetry.Colorimetric assays were used to determine gastric mucosal levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), as well as superoxide dismutase (SOD) activity. We demonstrated that inactivation of sensory nerves resulted in magnification of gastric mucosal damage induced by the WRS. In this process, oxidative stress, as reflected by an increase of MDA and 4-HNE tissue concentrations (an index of lipid peroxidation), as well as decrease of SOD activity, could play an important role. Aspirin, applied in a low dose, exerts a protective activity, possibly due to its metabolites, which possess the anti-oxidant and ROS scavanging properties. Pentoxyfilline-induced gastroprotection and hyperemia depends upon attenuation of the oxidative stress. This protection and hyperemia were, at least in part, attenuated by ASA.

19

Helicobacter pylori infection and gastric secretion in duodenal and gastric ulcer patients - the effect of eradication after one year

72%

Laszewicz W. , Zaremba-Woroniecka A. , Gabryelewicz A.

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tom 48

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nr 1

20

Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor

72%

Brzozowski T. , Konturek P. C. , Konturek S. J. , Pajdo R. , Schuppan D. , Drozdowicz D. , Ptak A. , Pawlik M. , Nakamura T. , Hahn E. G.

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2000

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tom 51

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nr 4,1