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Pancreatic heterotopia in the gallbladder: an incidental finding after cholecystectomy

100%

Sroczynski M. , Sebastian M. , Halon A. , Rudnicki J. , Sebastian A. , Agrawal A. K. , Piekarz P.

Folia Histochemica et Cytobiologica

2013

tom 51

nr 2

The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levels

100%

Krawczyk M. , Gruenhage F. , Mahler M. , Tirziu S. , Acalovschi M. , Lammert F.

nr 3

Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease. Additionally, insulin resistance - linked to the development of non-alcoholic steatohepatitis - increases the risk of developing gallstones. Here we assessed whether the PNPLA3 p.I148M (c.444 C>G) polymorphism affects glucose and lipid levels and increases gallstone risk. We analysed 229 individuals with gallstones from 108 families (age 24-80 years, BMI 17-55 kg/m2) and 258 gallstone-free controls (age 20-70 years, BMI 14-43 kg/m2). Fasting glucose, triglyceride and cholesterol serum levels were determined. The p.I148M polymorphism was genotyped using a PCR-based assay with 5'-nuclease and fluorescence detection. Case-control association tests and nonparametric linkage (NPL) analysis in sib-pairs were performed. Individuals carrying the [GG] genotype had significantly (P<0.0001) higher median fasting glucose levels as compared to [GC] and [CC] carriers. After adjustment for multiple testing, we detected a trend for an association between triglyceride levels and variant adiponutrin in gallstone patients (P=0.032), and gallstone cases carrying the genotype [CC] presented with significantly higher triglyceride levels than the corresponding controls (P<0.003). No significant effects on cholesterol metabolism were detected. Neither genotype distributions nor NPL scores provided evidence for association or linkage between the PNPLA3 variant and gallstones. In conclusion, homozygous carriers of the PNPLA3 risk allele display higher fasting glucose. Although this adiponutrin variant may affect triglyceride homeostasis, it does not increase the risk of cholelithiasis.

Comparison of uroliths and gallstones crystallization with metal crystallization

100%

Klimek L.

Archives of Foundry Engineering

2011

tom Vol. 11, iss. 3 spec.

117--120

The human organism creates different deposits in the form of minerals which play an important role in its functioning. Some of them located mainly in blood vessels, kidneys and urinary tracts, biliary tracts, salivary, pancreatic, new growths etc. have a determinately negative effect. Recognition of these minerals, getting to know the conditions in which they grow and first of all the processes of their appearance have a primary meaning in the possibility of prevention of their crystallization. The work shows the results of microscopic and diffractometric tests of uroliths and gallstones. On the basis of this research it is possible to state that there is a certain analogy in the crystallization process of these deposits with crystallization of metals. As far as the process of nucleation is concerned, only heterogenic nucleation takes place. But in the process of growth faced crystals and non-faced crystals appear. Thus, it can be assumed that there are some analogies in the process of metal crystallization with the crystallization of deposits in the human body.

Polysaccharides and mucin 5AC (MUC5AC) expression in gallbladder mucosa of young patients with gallstones as evaluated by spatial visualization and quantification

100%

Kasprzak A. , Malkowski W. , Helak-Lapaj C. , Seraszek A. , Kaczmarek E. , Adamek A. , Zabel M.

Folia Histochemica et Cytobiologica

2010

tom 48

nr 4

Zastosowanie metody analizy czynnikow glownych do oceny roli zelaza i manganu w skladzie chemicznym kamieni zolciowych

80%

Bogunia M. , Kwapulinski J. , Ahnert B. , Bogunia E. , Nogaj E. , Rutkiewicz J. , Mitko K. , Bebek M.

2006

tom 39

nr 4

391-395