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Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

100%

Anna Sęk-Mastej A. , Sabina Galiniak S. , Izabela Krawczyk-Marć I. , Krzysztof Balawender K. , Artur Szymczak A. , Maciej Kaniewski M. , Natalia Leksa N. , Marek Biesiadecki M. , Stanisław Orkisz S.

European Journal of Clinical and Experimental Medicine

2018

nr 2

85-91

Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.

Starotestamentowe życie nienarodzonych

63%

Węgrzyniak W.

Polonia Sacra

2013

tom 17

nr 1

The article aims to analyze the Old Testament’s idea of life before birth. Firstly, I examine some expressions describing sexual intercourse. Secondly, I study the meaning of the word הרה hārāh “to conceive”. Thirdly, I analyze some crucial texts (ad es. Rdz 25, 21– 24; Wj 21, 22–25; Hi 10; Ps 139). At the end, I offer a brief synthesis of the Old Testament’s idea about life between conception and birth.

Ochrana embrya a plodu v trestním a občanském právu

51%

Valc J.

Časopis zdravotnického práva a bioetiky (Journal of Medical Law and Bioethics)

2021

tom 11

nr 1

36-52

What is the status of an embryo and a foetus? This question has been always the object of interest not only to lawyers but also to experts in other disciplines. Despite the fact, that knowledge about the circumstances of the origin and development of human life during the prenatal period has greatly expanded, there is still no consensus on that, when and why each of us once became a person and a holder of rights. The intention of this article is not to provide a wide range of individual philosophical or legal approaches to the problem, but to perform a definition of the legal status of an embryo and a foetus in the Czech Republic, with the focus on the specifics of its legal protection.

Jaký je status embrya a plodu? Tato otázka je od nepaměti objektem zájmu nejen právníků, ale také odborníků z jiných vědních oborů. Přestože se znalosti ohledně okolností vzniku a vývoje lidského života během prenatálního období díky technologickému pokroku značně rozšířily, stále neexistuje shoda ohledně toho, kdy a na základě jakých kritérií se každý z nás stal kdysi osobou a nositelem práv. Záměrem tohoto článku není poskytnout širokou škálu jednotlivých filozofických či právních přístupů, ale vymezit základní východiska právního postavení embrya a plodu v českém trestním a občanském právu, a to se zaměřením na rozsah a specifika jeho právní ochrany.