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Bioequivalence study of two formulations of enrofloxacin following oral administration in chickens

100%

Posyniak A. , Zmudzki J. , Niedzielska J. , Biernacki B.

nr 2

The aim of this study was to demonstrate the bioequivalence of two formulations base on enrofloxacin i.e. between a test formulation Enrofloksacyna 10% per os (Biowet Drwalew) and the reference Baytril 10% (Bayer), according to a framwork required for the registration files. Both formulations were administered in a single oral administration at the recommended dose of 10 mg enrofloxacin per kg of b.w. in chickens. The study was conducted following conventional design, blood samples were collected until 72 h after drug application and analysed by validated method. The plasma disposition kinetics of enrofloxacin in chickens was similar following treatment with both formulations Cmax values (0.92 and 0.98 μg/ml, respectively) and were achieved at the 2nd h after administration of both formulations. None of the estimated pharmacokinetic parameters of both drug formulations were statistically different. Findings show that Enrofloksacyna 10% per os is equivalent to reference Baytril 10%.

Pathogenesis of quinolone-induced arthropathy: A review of hypotheses'

100%

Maslanka T. , Jaroszewski J. J. , Chrostowska M.

nr 4

The arthropathogenic effects of quinolones have been described in juvenile animals of multiple species such as dogs, rats, non-human primates, rabbits and guinea pigs. Several studies have been performed to clarify the exact mechanism leading to cartilage damage. In these studies, the investigators focused on the inhibitory effects of quinolones on DNA, collagen and proteoglycan synthesis and on the formation of oxygen-derived reactive molecules. Recently, it was suggested that quinolone-induced arthropathy is possibly associated with the magnesium-chelating properties of quinolones. However, the exact mechanism of quinolone-induced arthropathy is still unkown. This article reviews and summarizes several possible mechanisms for quinolone-induced arthropathy.

Analytical procedure for the determination of fluoroquinolones in animal muscle

84%

Posyniak A. , Mitrowska K.

nr 3

A liquid chromatography-fluorescence detection method for the determination of five fluoroquinolones in muscle tissue was proposed. The method is selective and robust enough for the required purposes. The whole procedure was validated in accordance with the Commission Decision 657/2002/EC. Detection capabilities were from 132.8 to 421.0 µg/kg, and recoveries ranged from 51.7% to 80.91%, depending on the analyte.

Antybiotykoterapia u świń cz.5. Charakterystyka fluorochinolonów

67%

Pomorska-Mol M.

nr 3

Leczenie zapalenia uszu u psów. Tak wiele możliwości - którą wybrać?

42%

Cole L.

tom 20

nr 5

Stosowane leki przeciwdrobnoustrojowe w terapii trzody chlewnej w latach 2010-2015 na podstawie Programu Wieloletniego

42%

Krasucka D. M.