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EN
Proximal femoral focal deficiency is an extremely rare congenital anomaly with only a few case reports in the literature. This case illustrates one diagnosed by prenatal ultrasound. The diagnosis may be isolated or associated with other abnormalities and syndromes. This report describes the early obstetrical ultrasound diagnosis, its evolution and associated findings throughout pregnancy. To the best of our knowledge, it is the first report associating this diagnosis with sickle cell trait. Another finding in our patient was a concomitant intrauterine growth restriction that we attribute to placental infarctions and a retro placental hemorrhage, also on the basis of sickle cell trait. At birth, placental weight was under the 10th percentile for gestational age. Obstetrical ultrasound in the prenatal diagnosis of proximal femoral focal deficiency is important, because early recognition of this malformation could provide useful information to parents and physicians regarding newborn management and therapeutic planning.
PL
Wrodzony niedorozwój kości udowej jest niezwykle rzadką wadą wrodzoną, zaledwie kilkukrotnie udokumentowaną w literaturze przedmiotu. Może występować niezależnie bądź też w powiązaniu z innymi zaburzeniami i zespołami wad. Niniejsza praca dotyczy przypadku rozpoznanego podczas diagnostyki ultrasonograficznej płodu. Opisujemy wczesne rozpoznanie w trakcie ultrasonograficznej diagnostyki położniczej, rozwój przypadku oraz powiązane ustalenia dokonane podczas ciąży. Wedle naszej najlepszej wiedzy jest to pierwszy opis przypadku, w którym wrodzony niedorozwój kości udowej wiąże się z niedokrwistością sierpowatą. Kolejną cechą było wewnątrzmaciczne zahamowanie wzrostu płodu, które przypisujemy zawałom łożyska oraz przedwczesnemu oddzieleniu łożyska, również na tle niedokrwistości sierpowatej. Przy urodzeniu waga łożyska znajdowała się poniżej 10. percentyla dla wieku ciążowego. Badanie ultrasonograficzne jest istotne w diagnostyce wrodzonego niedorozwoju kości udowej, ponieważ wczesne rozpoznanie tej malformacji daje rodzicom i lekarzom prowadzącym możliwość uzyskania cennych informacji dotyczących postępowania z dzieckiem po urodzeniu oraz zaplanowanie odpowiedniej terapii. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/wydawnictwa/volume-17-no-71
EN
Studies were performed on the levator palpebrae superioris muscle, isolated from foetuses aged 17 to 30 weeks. The number of muscle spindles varied from 2 in the 17th week to 7 in the 30th week. The length of the muscle spindles ranged from 20 to 500 mm, and the diameter varied from 10 to 70 μm. These observations show that the number of muscle spindles in levator palpebrae superioris muscles is significantly lesser than that in the extraocular muscles.
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tom 4
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nr 2
20-23
EN
Interrupted aortic arch is a rare and very difficult to diagnose congenital heart defect, which is divided into three types according to the place of interruption. The most common is type B, where the interruption is between the left carotid artery and left subclavian artery. This case report shows the description of the anomaly during the first and second trimester scan and review of the literature regarding interrupted aortic arch.
EN
The neural arches, transverse processes, spinous processes, and superior and inferior articular processes of each of the 5 lumbar vertebrae can often be found under the common heading of ‘posterior element’. The aim of our study was to assess the changes in geometry of the posterior elements of the foetal lumbar vertebrae during the foetal period. A total of 50 human foetuses, both female and male, from natural abortions, C-R length ranging from 58 to 220 mm, were examined. The methodology of the research included classical anatomical preparation, detailed measurements of the structural elements of the lumbar vertebrae and statistical analysis. Geometrical reconstruction was subsequently performed. The shape of the posterior elements changed gradually from wide and massive to slender. We observed a descending sequence of these alterations, the first vertebra to change being L₁, with L₅ the last. The dynamic of the change was at its greatest during the first 4 weeks of the period evaluated. On the basis of our observations we concluded that the geometry of the posterior elements of the lumbar vertebrae undergoes a process of a great transformation during the foetal period, a process which progresses dynamically until the 14th week of intra-uterine development. The associations with micro-angiogenesis, the ossification process and the notion of structural adaptation of the lumbar spine to heightening mechanical stress are also discussed.
7
Content available remote Influence of cadmium and copper on tissue element levels of pregnant rats
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EN
In the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.
EN
With the use of conventional anatomical dissection, radiography, digital and statistical analysis, morphometry and skeletopy of the pancreas was carried out in 60 human foetuses of both sexes (28 female, 32 male) between the 17th and 40th week of intrauterine life. The material was fixed in a 10% formalin solution. The age of the foetuses was determined by crown-rump (CR) lenght measurement on the basis of the Iffy et al. tables. Photographic documentation was made and then digitally processed in the Computer Image Digital Analysis System. The following parameters were taken into account: the length and width of 3 parts of the pancreas, namely the head, corpus and tail. Additionally, radiograms were made to obtain a projection of the gland on the vertebral column. Development of the pancreas was correlated with the age of the foetuses calculated on the basis of crown-rump (CR) lenght measurements. The correlation coefficient with CR was 0.998 for the pancreas length, 0.709 for the width of the head, 0.703 for the width of the corpus and 0.712 for the width of tail. Gender dimorphism was not found (p > 0.05) with regard to the morphometry of the pancreas. In the material under examination the pancreas did not change its position in relation to the vertebral column. The head projected on the vertebral column in the range Th₁₂–L₂ (most frequently L₁–L₂), the corpus on Th₁₂–L₂ and the tail on Th₁₁.
EN
The development of the spiral ganglion was studied in steps sections of 81 human temporal bones. By the 8th week, the spiral ganglion has already separated from the vestibular ganglion. At 13 weeks two distinct populations are observed that correspond to neuron and Schwann cells. At 15 weeks the spiral ganglion has increased its distance from the cochlear duct and is surrounded by mesenchyme near the scala tympani. At 14 weeks a gradual decrease in the nucleus-to-cell area ratio was observed in spiral ganglion neurons that may reflect a morphological adaptation to function. By the 23rd week the modiolus begins to ossify and the spiral ganglion is surrounded by bony trabeculae. The time course of spiral ganglion development follows that of the stria vascularis and organ of Corti, although maturation changes are still observed in the neuronal population even beyond 20 weeks.
EN
The study was performed on 82 small saphenous veins in human fetuses of both sexes aged 9 to 37 weeks. The earliest valves were observed in 13 week-old fetuses. In fetuses between 13 and 18 weeks old the number of valves increased from 1 to 8. In the older fetuses between 19 and 37 weeks the number of valves varied from 5 to 9 and does not seem to be related to age. During development more valves were found in the upper part of the small saphenous vein. The height of valves increases with age and differs between particular valves of the same vein.
15
Content available remote Prenatal Sonographic Diagnosis of Pierre-Robin Sequence - A Case Report
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EN
The rare anomalies diagnosed in prenatal ultrasonographic examination include Pierre-Robin sequence. The aim of the report was to demonstrate a well-documented case of Pierre-Robin sequence detected by ultrasonography at the 24th week of gestation, present the differentiation of Pierre-Robin sequence in the prenatal ultrasonography and to emphasize the importance of early sonographic diagnosis of the anomaly. The prenatal diagnosis of Pierre-Robin sequence in prenatal ultrasonographic assessment is of great importance as it permits planning further course of pregnancy as well as EXIT procedure and postnatal treatment.
EN
By means of anatomical and radiological methods and with help of the Computer Digital Image Analysis System the brachiocephalic trunk and the common carotid arteries in relation to the vertebral column were studied in 60 human fetuses. The vessels were found to be between the upper borders: of the third thoracic vertebra and the first cervical vertebra (Th3s-C1s). In the 6th month of the ontogenetic development the vessels descended by one vertebra and established their location in the next prenatal compartment (8-9) between the lower borders: of these same vertebra (Th 3i - C 1i ). We have counted the skeletopic age correlation coefficients of these vessels andfound the diminuation of their values. Sexual skeletopic dimorphisms have not been observed. These investigations have clinical implications.
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