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1 Cellular and Molecular Biology Letters

1 1996

1 Coakley W. T.

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Involvement of interfacial instability in morphological changes of some membrane-bound bodies

100%

Coakley W. T.

Cellular and Molecular Biology Letters

1996

tom 01

nr 3

Systems consisting of single membranes or of interacting membranes with an intervening aqueous layer can be modelled as interfacial regions. Treatments of the stability of thin fluid films against bending and squeezing waves give guidance on the behaviour of such regions. Evidence of bending wave instability on erythrocyte membranes when the spectrin component of the membrane skeleton is denatured is presented. There are two alternative outcomes of such instability. In one case a regular surface wave grows on the rim of the erythrocyte at rates of the order of 3 s-1 and vesicles pinch from the wave crests. In the second outcome the cell rounds up and the membrane partially internalises a discoid volume of suspending phase. The rim of that volume becomes unstable and sends vesicles into the cell. The outcome (internalisation or externalisation of membrane) can be controlled experimentally by altering the surface charge or the transmembrane potential or by exposure to amphiphilic drugs. When two interacting membranes of normal erythrocytes at room temperature adhere in the presence of adhesion-inducing polymers or of lectins two distinct adhesion outcomes are also possible. In one case parallel membranes form a continuous seam. In the second outcome localised regions of close contact formed at regular intervals along the membrane surface are separated by regions of larger normal separation. The characteristic lateral spacing of contact regions changes with different modifiers of the membrane interaction profile in a manner consistent with interfacial instability theory.