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Bioequivalence study of two formulations of enrofloxacin following oral administration in chickens

100%

Posyniak A. , Zmudzki J. , Niedzielska J. , Biernacki B.

nr 2

The aim of this study was to demonstrate the bioequivalence of two formulations base on enrofloxacin i.e. between a test formulation Enrofloksacyna 10% per os (Biowet Drwalew) and the reference Baytril 10% (Bayer), according to a framwork required for the registration files. Both formulations were administered in a single oral administration at the recommended dose of 10 mg enrofloxacin per kg of b.w. in chickens. The study was conducted following conventional design, blood samples were collected until 72 h after drug application and analysed by validated method. The plasma disposition kinetics of enrofloxacin in chickens was similar following treatment with both formulations Cmax values (0.92 and 0.98 μg/ml, respectively) and were achieved at the 2nd h after administration of both formulations. None of the estimated pharmacokinetic parameters of both drug formulations were statistically different. Findings show that Enrofloksacyna 10% per os is equivalent to reference Baytril 10%.

Antybiotykoterapia u świń cz.5. Charakterystyka fluorochinolonów

67%

Pomorska-Mol M.

nr 3

Leczenie zapalenia uszu u psów. Tak wiele możliwości - którą wybrać?

42%

Cole L.

tom 20

nr 5