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1 Acta Biochimica Polonica

1 1993

1 Ulaszewski S.

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Interactions between the gene products of pma1 encoding plasma membrane H+-ATPase, and pdr1 controlling multiple drug resistance in Saccharomyces cerevisiae

100%

Ulaszewski S.

tom 40

nr 4

In Saccharomyces cerevisiae, the pmal mutations controlling the vanadate resistance of the H+-ATPase activity from the plasma membrane, map on chromosome VII in the vicinity of pdrl mutations controlling multiple drug resistance. However, the pmal-1 mutants exhibit a genotype and a multidrug resistant phenotype quite different from those obtained for pdrl mutants. Quantitative modifications of cycloheximide and N,N'-(p-xylylidene)-bis-aminoguanidine-2HCl resistance are observed in diploids containing the pmal and pdrl genes in trans configuration. Each of the pdrl mutations interacts with pmal as shown by a decrease in the ATPase activity in pdrl/pmal diploids. The in vitro resistance of ATPase activity to vanadate is totally or partially suppressed in pdrl mutants in haploid double mutants. These results suggest that the expression of PMA1 might be controlled by the PDR1 gene product.