This paper proposes a method to demonstrate that 123789 Dibenzodioxine and 2378 Dibenzofurane enhance membrane permeability to the ions in mitochondria from rat liver. The procedure can be employed: i) as a general method to assess the enhancement of membrane permeability by toxic compounds, ii) to study the decrease in conductivity of carrier-systems induced by inhibitors of transport, and iii) to study the behaviour of ion-carrier systems which are potentially dependent on biological membranes.
Omówiono polichlorowane dibenzodioksyny (PCDDs) oraz pokrewne im związki. Wskazano na główne źródła ich powstawania oraz omówiono problemy analityczne związane z identyfikacją i oznaczaniem tych związków.
EN
Polychlorinated dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) as well as similar compounds are described and chracterized as a group of environmental pollutants which have been arousing interest only since a short time. The toxicity of the compouds in this group of xenobiotics is compared with that of other compounds generally regarded as highly toxic. The main sources of origin of PCDDs/PCDFs are found in nearly all fields of the technological actions of man. Problems of detection and identification of these compouds extremely difficult in analysis are discussed. These problems are a challenge to even specialists laboratories.
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