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1 Polish Journal of Environmental Studies

1 1999

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Metabolic interaction in rats treated with acetylsalicylic acid anbd trichloroethyline

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Zielinska-Psuja B. , Orlowski J. , Plewka A. , Kaminski M. , Kowalowka-Zawieja J. , Zieba-Proc B.

Polish Journal of Environmental Studies

1999

tom 08

nr 5

The influence of acetylsalicylic acid (ASA) on elimination of trichloroacetic acid and trichloroethanol in the urine and liver and kidney of cytochrome P-450-dependent monooxygenase systems in rats exposed to trichloroethylene (TRI) vapours were examined. The obtained results show that acetylsalicylic acid decreased the elimination of both trichloroethylene metabolites and induced cytochrome P-450 concentration in the liver, whereas slightly inhibited cytochrome b5 and activites of NADPH-cytochrome P-450 reductase and NADH-cytochrome b5 reductase. After mixed exposures, acetylsalicylic acid elevated cytochrome P-450 concentration and NADPH-cytochrome P-450 reductase activity to values observed in the control group. The concentration of cytochrome b5 was much lower than after ASA or trichloroethylene alone. The activity of NADPH-cytochrome P-450 reductase was strongly inhibited by TRI, whereas in ASA presence was elevated, but it was still lower than in control. Acetylsalicylic acid stimulates cytochrome P-450, however other compounds of MFO system do not react positively on this ester.