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Molecular identification of Paramecium bursaria syngens and studies on geographic distribution using mitochondrial cytochrome C oxidase subunit I (COI)

100%

Zagata P. , Greczek-Stachura M. , Tarcz S. , Rautian M.

Folia Biologica

2015

tom 63

nr 1

The role of alternative oxidase in hypoxic metabolism of nitric oxide

84%

Igamberdiev A. , Shah J. , Cochrane D. , Gupta K. , Vanlerberghe G.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2013

tom 94

nr 2

Biomarkers of leguminous plant viability in response to soil contamination with diclofenac

67%

Ziolkowska A. , Piotrowicz-Cieslak A. I. , Rydzynski D. , Adomas B. , Nalecz-Jawecki G.

Polish Journal of Environmental Studies

2014

tom 23

nr 1

Pharmaceuticals have become an emerging environmental protection problem due to their presence in water and soil ecosystems. Reliable cell viability biomarkers (mitochondrial and cytosol distribution of cytochrome c oxidase activity), germination, and growth of seedlings were assessed to be sensitive endpoints of diclofenac toxicity. Moreover, the content of soluble carbohydrates in seedlings of three leguminous plants was an additional indicator of germination. The tested diclofenac concentrations (from 0 to 12 mM) in the three plant species (lupin, pea, and lentil) resulted in increased activity of the enzyme in cytosol, and a decreased activity in mitochondrions. The increase of the cytochrome c oxydase activity in cytosol was most rapid in pea and slowest in lupin. The decrease in mitochondrions was gradual, yet in roots growing in the soil contaminated with 12 mM of diclofenac, from 35 to 68% of total enzyme activity leaked from the mitochondrion to the cytoplasm. The dynamics of seedling growth was a better parameter of soil contamination with diclofenac than germination. On the basis of the described morphological and biochemical features, it was found that diclofenac is decidedly less phytotoxic toward leguminous plants (lupin, pea, lentil) than e.g. sulfamethazine. The research has shown that carbohydrate metabolism is a good parameter of seedling growth, but it is not an indicator of contamination and thus cannot be applied to assess soil ecosystem contamination with medicines.

Interaction of an anticancer ruthenium complex HInd[RuInd2CI4] with cytochrome C

67%

Trynda-Lemiesz L.

nr 1

Cytochrome c is an important electron transfer protein in the respiratory chain, shuttling electrons from cytochrome c reductase to cytochrome c oxidase. Extensive chemical modification studies indicate significant electrostatic interactions between these proteins and show that all structural and conformational changes of cytochrome c can influence the electron transport. In the present work we examine the effect of an anticancer ruthenium complex, trans-Indazolium (bisindazole) tetra- chlororuthenate(III) (HInd[RuInd2Cl4]), on the conformation of cytochrome c, the state of the heme moiety, formation of the protein dimer and on the folding state of apocytochrome c. For this purpose, gel-filtration chromatography, absorption second derivative spectroscopy, circular dichroism (CD) and inductively coupled plasma atomic emission spectroscopy (ICP(AES)) were used. The present data have revealed that binding of the potential anticancer drug HInd[RuInd2Cl4] complex to cytochrome c induces a conformation of the protein with less organized secondary and tertiary structure.