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Cushing’s disease: is pasireotide LAR a breakthrough in adjuvant therapy after unsuccessful surgery?

100%

Witek P. , Mazur M. , Witek J.

nr 4

176-179

Cushing’s disease is a rare endocrine disorder caused by ACTH-secreting pituitary adenoma. The treatment of choice is a transsphenoidal surgery performed by an experienced neurosurgeon. However, in some patients adjuvant treatment is required due to ineffective surgery or disease recurrence. This article discusses new aspects of pharmacological treatment of ACTH-dependent hypercortisolism in light of a recent publication reporting the efficacy and safety of once a month pasireotide LAR injections in Cushing’s disease.

Corticotrophin releasing factor modulates the morphine effect on the mu, delta and kappa opioid receptor agonist binding in lamb hypothalamic-pituitary-adrenal axis

86%

Pierzchala-Koziec K. , Zubel-Lojek J. , Latacz A. , Oclon E.

tom 21

Comparison of the activity of ACTH 4-10 fragment and analogue and tripeptide pro-gly-pro during 3-hour-observation of rabbits' behaviour under acute stress conditions

86%

Teter M. , Dec-Szlichtyng M. , Cygan B. , Kozlovska M. M.

nr 1

Immunohistochemical detection of prolactin in clinically non-functioning pituitary adenomas

72%

Winczyk K. , Toszek J. , Swietoslawski J. , Wojtczak E. , Pawlikowski M.

nr 2

The lysosomal system of some cell types of the adenohypophysis

72%

Bacsy E. , Moi V. D. , Gaal G. , Rappay G.

Folia Histochemica et Cytobiologica

1984

tom 22

nr 3-4