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Immunospecific nuclear proteins of colorectal tumors

100%

Szymczyk P. , Krajewska W. M. , Jakubik J. , Berner A. , Berner J. , Brocki M. , Rajczyk B. , Kilianska Z.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

Electrophoretically specific nuclear proteins of human colon adenocarcinoma with mol. wt of 35-40 kDa were used as immunogen to produce rabbit antiserum. Expression of cancer-specific antigens was investigated by Western blot technique among nuclear proteins from normal and cancerous mucosa. Obtained antiserum crossreacted mainly with 36 kDa polypeptide in 23 of 26 (88,5%) colorectal tumor nuclear fractions but not with any of normal ones. It was also observed that this antiserum recognized 36 kDa antigen in 10 of 12 and 6 of 7 nuclear fractions from other cancers, ie. gastric and lung, respectively. In part of studied tumors antiserum crossreacted also with the antigens of 38 and 32-33 kDa. Expression of 36 and 32-33 kDa components seems to be correlated with colorectal cancer progression from A to B stage of disease according to the classification of Dukes. Immunoblot analysis revealed that cancer-specific 36 kDa polypeptide, mainly associated with nuclear compartment, can be also detected within 10P and 100P fractions of colorectal tumors.

DNA ploidy and morphology of colon tumors in the adenoma–carcinoma sequence

84%

Staarmann J. , Kotb W. F. A. , Petersen I.

Folia Histochemica et Cytobiologica

2015

tom 53

nr 1

Activity of cancer procoagulant [CP] in serum of patients with cancer of lung, breast, oesophagus and colorectum

84%

Rucinska M. , Furman M. , Skrzydlewski Z. , Zaremba E.

Acta Biochimica Polonica

1997

tom 44

nr 1

Activity of cancer procoagulant (CP) was studied in blood serum of 90 patients with cancer of lung, breast, oesophagus and colorectum, and of 15 healthy people. The activity of CP was determined by the coagulation method. Sera of patients with cancer showed higher mean activity of CP than sera of healthy control. Of the 90 cancer patients 78 were identified correctly by this test as having cancer (sensitivity 85%). In the case of lung and colorectal cancers the higher CP activity was observed the more advanced was the clinical stage of cancer, and the test was positive in 100%. After radical removal of malignant tumor of lung, decreased CP activity was found.