Wyniki wyszukiwania - Biblioteka Nauki

1

A concurrent presentation of nonspecific colitis as well as likely myocarditis

100%

Heavener T. , Jepson M. , Bushe B. , Thotakura S. , Chiles C.

Progress in Health Sciences

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2018

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tom 8(1)

225-230

EN

An ST-segment elevation myocardial infarction represents a time-sensitive cardiac pathology with utmost importance placed upon timely coronary angiography with percutaneous coronary intervention. While emphasis is placed on atherosclerotic or thrombotic coronary occlusion, it is important to recognize other etiologies which may present in a similar fashion. This case demonstrates a 71-year-old female patient with prior coronary artery disease and stenting who presented with acute abdominal pain and elevated cardiac biomarkers as well as ST-segment elevation on initial EKG. Coronary angiography revealed only mild to moderate coronary lesions and patent stents while echocardiography was essential unchanged from prior evaluation. Computed tomography of the abdomen would show findings suggestive of infectious colitis and empiric antibiotics led to full resolution of symptoms. While no definitive cause for her cardiac manifestations was discovered, the authors propose coronary vasospasm or myo-pericarditis as likely etiologies in response to an overwhelming inflammatory state. The case underscores the importance of formulating a comprehensive differential diagnosis during the initial workup of a ST-segment elevation myocardial infarction.

2

Preventive use of Lactobacillus plantarum LS/07 and inulin to relieve symptoms of acute colitis

100%

Hijová E. , Šoltésová A. , Salaj R. , Kuzma J. , Strojný L. , Bomba A. , Gregová K.

Acta Biochimica Polonica

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2015

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tom 62

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nr 3

553-557

EN

The aim of presented study was to investigate the influence of Lactobacillus plantarum LS/07 and inulin on the activity of β-glucuronidase enzyme, and counts of coliform and lactobacilli in fresh caecal digesta, cytokine levels (IL-6, IL-8), and trancription nuclear factor kappa beta (NFκB) activities in colon tissue and blood samples of rats with dextran sulphate sodium (DSS) induced acute colitis. The rats were randomly divided into four groups - CG, AC, AC+PRE and AC+PRO. Colitis was induced using of 5% DSS in drinking water for 7d. DSS application increased activity of β-glucuronidase (P < 0.001), increased counts of coliforms, and decreased lactobacilli counts (P < 0.05) in comparison to control group. Serum and tissue levels of IL-6 and IL-8 as well as tissue NFκB activities showed increased expression in acute colitis group. Inulin diet modified counts of microorganims and decreased β-glucuronidase activity, suppressed NFκB activities (P < 0.001) and down regulate synthesis of IL-6 (P < 0.01) in serum and colon tissue and tissue IL-8 (P < 0.05). Lactobacillus plantarum LS/07 decreased β-glucuronidase activity (P < 0.05), levels of IL-6 and IL-8 (P < 0.001). These results were consistent with the addition of histological findings. Our results indicate that dietary intake of Lactobacillus plantarum LS/07 and inulin suppressed expression observed markers, which play an important role in the inflammatory process, which predisposes their use in prevention or treatment of acute colitis.

3

Activation of dendritic cells by nematode antigens during colitis

88%

Maruszewska-Cheruiyot M. , Donskow-Lysoniewska K. , Piechna K.

Annals of Parasitology

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2016

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tom 62

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nr Suppl.

4

Ultrasound findings in extragenital endometriosis

88%

Dong Y. , Braden B. , Klinger C. , Ripolles T. , Dietrich C. F.

Journal of Ultrasonography

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2018

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tom 18

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nr 74

247-254

EN

We present a report on ultrasound findings in extragenital endometriosis and a literature review accompanied by illustrations. Intestinal endometriosis should be considered in female patients of reproductive age who present with constipation, gastrointestinal bleeding, nausea, vomiting, cramp-like abdominal pain, diarrhoea and pelvic pain. Although definitive preoperative diagnosis of endometriosis is difficult, clinical suspicion and appropriate imaging might prevent extensive surgical procedures with higher morbidity. Contrast-enhanced ultrasound is an efficient non-invasive imaging method without any radiation exposure that supports the early diagnosis of intestinal endometriosis and may help assess the vascularization of endometriotic lesions within the distinct layers of the intestinal wall.

PL

Autorzy przedstawiają sprawozdanie dotyczące badań ultrasonograficznych przeprowadzonych u pacjentek z endometriozą zlokalizowaną poza narządami rozrodczymi wraz z przeglądem piśmiennictwa poparte przykładami klinicznymi. U pacjentek w wieku rozrodczym, u których występują zaparcia, krwawienie z przewodu pokarmowego, nudności, wymioty, bolesne skurcze brzucha, biegunka i ból w obrębie miednicy mniejszej należy rozważyć endometriozę jelitową. Choć postawienie ostacznego rozpoznania przedoperacyjnego jest trudne, wysunięcie klinicznego podejrzenia oraz odpowiednie badania obrazowe mogą pozwolić na uniknięcie rozległego zabiegu chirurgicznego obarczonego wyższą częstością powikłań. Badanie ultrasonograficzne z użyciem środka kontrastującego to skuteczna i nieinwazyjna metoda obrazowania, która nie wiąże się z narażeniem pacjentki na promieniowanie oraz która może zasugerować wczesne rozpoznanie endometriozy jelitowej i pomóc w ocenie unaczynienia zmian endometrialnych w obrębie poszczególnych warstw ściany jelita.

5

Effect of iron supplementation on intestinal function and oxidative stress in piglets with induced colitis

75%

Chen Q. , Le G. W. , Shi Y. H. , Zhang S. M. , Jin X.

Journal of Animal and Feed Sciences

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2007

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tom 16

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nr 2

205-213

6

Experimental inflammatory bowel disease - role of T cells

75%

Szczepanik M. , Gryglewski A. , Bryniarski K. , Stachura J. , Ptak W.

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nr 2

7

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

75%

Holma R. , Salmenpera P. , Virtanen I. , Vapaatalo H. , Korpela R.

Journal of Physiology and Pharmacology

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2007

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tom 58

|

nr 3

EN

Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor antagonist montelukast on a mild colitis model in rats. Colitis was induced by administrating 4% dextran sulphate sodium (DSS, MW 45 000) in drinking water for 9 days. Montelukast (10 mg/kg/day) or vehicle was given by gastric gavage once daily simultaneously with DSS administration. A healthy control group receiving water as drinking fluid and vehicle by gastric gavage was included. Body weight loss, consistency of faeces (loose/diarrhoea) and occult blood in the faeces/ gross bleeding were assessed on days 6 - 9. After sacrifice, the following were assessed: colonic histology, the expression of inducible nitric oxide synthase, macrophage/monocyte marker ED1, cyclooxygenase-1 and cyclooxygenase-2, as well as the production of leukotriene B4 and E4, prostaglandin E2, its metabolite bicyclic-prostaglandin E2 and thromboxane B2 in the colonic tissue incubation in vitro. Rats receiving DSS exhibited bloody diarrhoea from day 6 onwards. Montelukast significantly reduced the occult blood in the faeces/ gross bleeding, maintained normal body weight gain and tended to decrease the ratio of leukotriene B4/ prostaglandin E2 production in the colon in vitro. The results indicate that montelukast has some potential to ameliorate mild experimental colitis induced by DSS.

8

Dual role of endogenous nitric oxide in development of dextran sulfate sodium-induced colitis in rats

75%

Rumi G. , Tsubouchi R. , Nishio H. , Kato S. , Mozsik G. , Takeuchi K.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 4

EN

The role of nitric oxide (NO) in the etiology of ulcerative colitis is controversial with reports of the improvement and aggravation of colonic lesions by inducible NO synthase (iNOS) inhibitors. In the present study, we compared the effect of the selective iNOS inhibitor aminoguanidine and the nonselective NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on a dextran sulfate sodium (DSS)-induced model of colitis in rats. Experimental colitis was induced by a 3% DSS-solution added to drinking water for 7 days. Aminoguanidine (5~20 mg/kg) and L-NAME (10 mg/kg) were administered p.o. twice daily for the first 3 days, the last 3 days or all 6 days of DSS treatment. Body weight and severity of colitis (diarrhea, bloody feces) were observed over a period of 7 days. DSS treatment resulted in severe colonic lesions, accompanied by diarrhea, bloody feces, decrease of body weight and colon shortening. All of the parameters investigated improved significantly with aminoguanidine treatment at 20 mg/kg for 6 days or the last 3 days of DSS-treatment, but L-NAME did not significantly affect the colitis during these periods. When L-NAME or aminoguanidine was given in the first 3 days of DSS treatment, the colonic lesions were slightly aggravated by L-NAME but not affected by aminoguanidine. The expression of iNOS mRNA was observed from the 3rd day of DSS treatment. These results suggested that endogenous NO exerts a biphasic influence on DSS-induced colitis, depending on the NOS isoenzyme; a beneficial effect of NO derived from constitutive NOS and a detrimental effect of NO produced by iNOS in the development of colitis.

9

St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis of rats through the induction of pregnane X receptors and/or P-glycoproteins

63%

Sehirli A. O. , Cetinel S. , Ozkan N. , Selman S. , Tetik S. , Yuksel M. , Dulger F. G. A.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 2

10

Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis

63%

Krajewska J. B. , Pietruszka P. , Tomczyk D. , Chen C. , Owczarek A. , Karolewicz B. , Czapor-Irzabek H. , Gorniak A. , Fichna J.

Journal of Physiology and Pharmacology

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2019

|

tom 70

|

nr 2

11

Exploring novel colon-targeting antihistaminic prodrug for colitis

63%

Dhaneshwar S. , Gautam H.

Journal of Physiology and Pharmacology

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2012

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tom 63

|

nr 4

12

High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice

63%

Zielinska M. , Szymaszkiewicz A. , Salaga M. , Zatorski H. , Wlodarczyk J. , Jacenik D. , Kordek R. , Krajewska W. M. , Misicka A. , Fichna J. , Sacharczuk M.

Journal of Physiology and Pharmacology

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2018

|

tom 69

|

nr 5

13

Prostaglandins and inflammation: the cyclooxygenase controversy

63%

Morteau O.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

|

nr 6 Spec.Iss.

473-480

14

Curcumin improves experimentally induced colitis in mice by regulating follicular helper T cells and follicular regulatory T cells by inhibiting interleukin-21

63%

Li S.-Q. , Lv X.-D. , Liu G.-F. , Gu G.-L. , Chen R.-Y. , Chen L. , Fan J.-H. , Wang H.-Q. , Liang Z.-L. , Jin H. , Qin L.-F. , Xie Y.-F. , Lu F. , Jiang H.-X. , Zhan L.-L. , Lv X.-P.

Journal of Physiology and Pharmacology

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2021

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tom 72

|

nr 1

15

The pathogenic role of Blastocystis isolated from patients with irritable bowel syndrome and colitis from Iasi, Romania

63%

Matiut D. S. , Hritcu L.

Acta Parasitologica

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2015

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tom 60

|

nr 1

16

Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid [TNBS]-induced colitis

63%

Engel M. A. , Kellermann C. A. , Burnat G. , Hahn E. G. , Rau T. , Konturek P. C.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 1

89-97

EN

This study was performed to assess whether mice lacking the cannabinoid receptor CB1, CB2 or both receptors show increased susceptibility to TNBS colitis in comparison to wildtype mice. Previously, activation of CB1 and CB2 receptors showed attenuation of TNBS colitis in mice. The aim of the study was to investigate the susceptibility of three mouse strains CB1-, CB2- and CB1+2 double knockout mice in the model of TNBS colitis. The different knockout mice were given each a single enema with TNBS 7 mg, volume 150 µl (in 50% ethanol solution) on day 1. Control group (C57BL/6 mice) received the same concentration of TNBS enema and each strain received vehicle application of 150 µl 50% ethanol solution. After a 3-day period, the animals were sacrificed and their colon excised. A scoring system was used to describe macroscopical and histological changes. Messenger RNA-expression of TNF- and IL-1ß as pro-inflammatory markers was measured by RT-PCR. All three knockout strains showed increased susceptibility to TNBS colitis quantified by macroscopical and histological scoring systems and pro-inflammatory cytokine expression in comparison to the TNBS control group (wild type C57BL/6 animals). Mice lacking the CB1-, CB2-receptor or both receptors showed aggravation of inflammation in the model of TNBS colitis. Lacking of both cannabinoid receptors did not result in potentiation of colitis severity compared to lacking of each CB1 or CB2, respectively. These results suggest that the endocannabinoid system may have tonic inhibitory effects on inflammatory responses in the colon.

17

Anti-inflammatory effects of nesfatin-1 in rats with acetic acid - induced colitis and underlying mechanisms

63%

Ozturk C. C. , Oktay S. , Yuksel M. , Akakin D. , Yarat A. , Kasimay Cakir O.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 5

18

Roles of nitric oxide (NO) and NO synthases in healing of dextran sulfate sodium-induced rat colitis

63%

Aoi Y. , Terashima S. , Ogura M. , Nishio H. , Kato S. , Takeuchi K.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 2

EN

We examined the effects of various NO inhibitors on the healing of DSS-induced rat colitis. Experimental colitis was induced by feeding rats for 6 days with 2.5% DSS in drinking water. After DSS treatment, the animals were fed normally and killed various days up to 7 days later. L-NAME (a nonselective NOS inhibitor) or aminoguanidine (a selective iNOS inhibitor) was given p.o. twice daily for 6 days starting from the termination of DSS treatment. The area of lesions, colon length and MPO activity were measured on day 7 after DSS treatment. DSS treatment caused severe lesions in the colon, accompanied by an increase in MPO activity and a decrease in colon length. The lesions healed gradually after discontinuation of DSS treatment, with a histological restoration and subsidence of inflammation. The healing of DSS-induced colonic lesions was significantly impaired by daily administration of L-NAME or aminoguanidine, the effects being all but equivalent between these drugs, and the effect of L-NAME was significantly reverted by the co-administration of L-arginine. The expression of nNOS protein was observed in the colonic mucosa with or without DSS treatment, while those of iNOS and eNOS were markedly upregulated after DSS treatment. Likewise, the expression of VEGF was also up-regulated in the colon following DSS treatment, and this response was suppressed by both L-NAME and aminoguanidine. These results suggest that endogenous NO produced by mainly iNOS and partly eNOS contributes to the healing of DSS-induced colonic lesions, through the upregulation of VEGF expression and enhancement of angiogenesis.

19

Beneficial anti-inflammatory effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in the treatment of dextran sulfate sodium-induced colitis in mice

51%

Salmenkari H. , Pasanen L. , Linden J. , Korpela R. , Vapaatalo H.

Journal of Physiology and Pharmacology

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2018

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tom 69

|

nr 4

20

Influence of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist, rosiglitazone and antagonist , biphenol-A-diglicydyl ether (BADGE) on the course of inflammation in the experimental model of colitis in rats

51%

Dworzanski T. , Celinski K. , Karolczuk A. , Slomka M. , Radej S. , Czechowska G. , Madro A. , Cichoz-Lach H.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 6