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Effect of chronic ethanol treatment and the abstinence period on the ethanol elimination by isolated rat liver lesioned by carbon tetrachloride

100%

Rajtar G. , Kleinrok Z.

Acta Physiologica Polonica

1990

tom 41

nr 7

Rajtar G. and Kleinrok Z.: Effect of chronic ethanol treatment and the abstinence period on the ethanol elimination by isolated rat liver lesioned by carbon terachloride Acta Physiol. Pol. The study was carried out on perfused livers isolated from rats receiving ethanol (EtOH) as their only drinking fluid for the period of 4 weeks. Twelve, 24, 72 and 120 hours after EtOH withdrawal the livers were isolated and perfused with 100 ml of perfusion mixture with addition of EtOH (0.2% final concentration). After 12 hours of EtOH withdrawal acceleration of the EtOH elimination from perfusate was observed. It returned to the control level after 24 hours, but after 72 and 120 hours of abstinence the rate of EtOH elimination from perfusate was found to diminish. CC1₄ injected to the rats in doses of 2 and 5 mmoles/kg once a week for the period of 4 or 8 weeks, resulted in decreased EtOH elimination from the perfusate. In the EtOH-drinking group previously treated with CC1₄ we found that irrespective of the time of EtOH withdrawal, EtOH elimination did not differ from that in the respective CC1₄ treated group, only 12 hours after its withdrawal EtOH elimination was decreased in livers injured with CC1₄ in dose of 5 mmoles/kg.

Influence of some psychotropic drugs on the ethanol elimination by the isolated liver of rats chronically fed with ethanol

84%

Rajtar G. , Kleinrok Z.

Acta Physiologica Polonica

1990

tom 41

nr 7

Rajtar G. and Kleinrok Z.: Influence of some psychotropic drugs on the ethanol elimination by the isolated liver of rats chronically fed with ethanol. Acta Physiol. Pol. During a 4-week period the rats received ethanol (EtOH), as their only drinking fluid, in a concentration ranging from 6% to 20%. In the period of 72 hours after EtOH withdrawal the rats received diazepam (DZP), imipramine (IMI) or caffeine (CAFF) i.p. twice a day in a 12-hours interval. In the experiments carried out on the livers isolated from these rats, we observed the diminution of the rate of EtOH elimination from the perfusate by the livers of DZP and IMI treated rats. CAFF did not change the rate of EtOH elimination.

Skeletal muscle wasting occurs in adult rats under chronic treatment with paracetamol when glutathione-dependent detoxification is highly activated

84%

Mast C. , Joly C. , Savary-Auzeloux I. , Remond D. , Dardevet D. , Papet I.

Journal of Physiology and Pharmacology

2014

tom 65

nr 5

A new ulcer model unhealed gastric ulcers, induced by chronic treatment with indomethacin in rats with acetic acid ulcers

67%

Amagase K. , Okabe S.

Journal of Physiology and Pharmacology

1999

tom 50

nr 2