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ATP-sensitive Kplus transport in adrenal chromaffin granules

100%

Szewczyk A. , Lobanov N. A. , Kicinska A. , Wojcik G. , Nalecz M. J.

nr 1

Intracellular potassium and chloride channels: An update

100%

Debska G. , Kicinska A. , Skalska J. , Szewczyk A.

Acta Biochimica Polonica

2001

tom 48

nr 1

Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targets for pharmacologically active compounds, e.g. mitochondrial potassium channels interact with potassium channel openers such as diazoxide. This review describes current observations concerning the properties and functional roles of intracellular potassium and chloride channels.

Myosin VI is associated with secretory granules and is present in the nucleus in adrenal medulla chromaffin cells

84%

Majewski L. , Sobczak M. , Redowicz M. J.

Acta Biochimica Polonica

2010

tom 57

nr 1

109-114

Myosin VI (MVI) is the only known myosin walking towards minus end of actin filaments. Here, MVI, but not myosins IB or IIB, was detected in chromaffin granules isolated from bovine medulla and found to be tightly associated with the granule apical surface. MVI also localized to secretory granules within rat pheochromocytoma PC12 cells as well as to the Golgi apparatus, endoplasmic reticulum and clathrin-coated pits. Notably, it was also found in the nucleus. RT-PCR revealed that MVI splice variants with a large insert (LI), characteristic of polarized cells, were barely detectable in PC12 cells, whereas variants with a small insert (SI) were the major isoforms. The presented data indicate that MVI in adrenal medulla cells is engaged in secretory vesicle trafficking within the cytoplasm and possibly also involved in transport within the nucleus.

Guinea pig adrenal medullary SGC (SIF) cells. Ultrastructurial, cytochemical and biochemical investigations. Morphobiochemical markers centifying the appurtenance of the cells to paraneurons

84%

Kmiec B. L.

Folia Histochemica et Cytobiologica

1986

tom 24

nr 4

The heterogeneity of ion channels in chromaffin granule membranes

84%

Hordejuk R. , Szewczyk A. , Dolowy K.

nr 3

Chromaffin granules are involved in catecholamine synthesis and traffic in the adrenal glands. The transporting membrane proteins of chromaffin granules play an important role in the ion homeostasis of these organelles. In this study, we characterized components of the electrogenic 86Rb+ flux observed in isolated chromaffin granules. In order to study single channel activity, chromaffin granules from the bovine adrenal medulla were incorporated into planar lipid bilayers. Four types of cationic channel were found, each with a different conductance. The unitary conductances of the potassium channels are 360 ± 10 pS, 220 ± 8 pS, 152 ± 8 pS and 13 ± 3 pS in a gradient of 450/150 mM KCl, pH 7.0. A multiconductance potassium channel with a conductivity of 110 ± 8 pS and 31 ± 4 pS was also found. With the exception of the 13 pS conductance channel, all are activated by depolarizing voltages. One type of chloride channel was also found. It has a unitary conductance of about 250 pS in a gradient of 500/150 mM KCl, pH 7.0.