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Multi-molecule imaging and inter-molecular imaging in nuclear medicine

100%

Shimazoe K. , Uenomachi M.

Bio-Algorithms and Med-Systems

2022

tom Vol. 18, no. 1

127--134

Multi-molecule imaging and inter-molecular imaging are not fully implemented yet, however, can become an alternative in nuclear medicine. In this review article, we present arguments demonstrating that the advent of the Compton positron emission tomography (Compton-PET) system and the invention of the quantum chemical sensing method with double photon emission imaging (DPEI) provide realistic perspectives for visualizing inter-molecular and multi-molecule in nuclear medicine with MeV photon. In particular, the pH change of InCl3 solutions can be detected and visualized in a three-dimensional image by combining the hyperfine electric quadrupole interaction sensing and DPEI. Moreover, chemical states, such as chelating, can be detected through angular correlation sensing. We argue that multi-molecule and chemical sensing could be a realistic stream of research in future nuclear medicine.

All-optical sensor based on nonlinear multimode interference coupler features

100%

Tajaldini M. , Jafri M. Z. M.

Optica Applicata

2015

tom Vol. 45, nr 3

327--340

In this study, we investigate the sensing applications in the presence of the nonlinear effects by proposing an all-optical sensor and considering nonlinear effects on modal propagation and output intensity based on an ultra-compact nonlinear multimode interference coupler. The sensor can be tuned to have the highest sensitivity in the wavelength and refractive index ranges and can detect water-soluble chemicals, air-pollutions, earthquake wave, blood parameters, and heart operation. The results indicate high output sensitivity to input wavelength whereas the nonlinear effects appear in the medium. This sensitivity led us to propose a wave sensor of both transverse and longitudinal waves, such as acoustic and light waves, when an external wave interacts with an input waveguide. For instance, this sensor can be implemented using a long input that is inserted in the land, and any wave could then be detected from the Earth. The visible changes in intensity at the output facet in various refractive indices of the surrounding layer show the high sensitivity to the refractive index of the surrounding layer, which is the foundation of introducing a sensor. Generally, the results show the high efficiency of nonlinear effects in all-optical sensing performances.