Wyniki wyszukiwania - Biblioteka Nauki

1

Evaluation of toxicological threat to health caused by some carcinogenic factors in the working environment of an industrial plant

100%

Wojcik A. , Brzeski Z. , Kolodziej K. , Lojko W. , Letkiewicz D. , Sieklucka-Dziuba M.

Polish Journal of Environmental Studies

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2000

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tom 09

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nr 6

531-535

EN

This study was carried out in a car factory at workplaces in various states of activity. The measurements of substances enlisted as carcinogenic found at workplaces in some departments in 1995-1997 was carried out as well as the evaluation of microclimatic conditions and the evaluation of sick absenteism in the whole factory. Analysis of results revealed that microclimates in the rooms in the studied departments did not exceed permissible hygienic standards, except for some workplaces in the suspension springs department and the tool room. The analysis of exposure to particular/specific factors in 1995-1997 enlisted among carcinogenic substances did not reveal any toxicological health hazard. Sick absenteism in the whole factory and studied departments in the analyzed period varied. The prevailing group of diseases were diseases of the respiratory system. Morbidity from cancer was low.

2

Wplyw pol elektromagnetycznych na organizmy zywe jako czynnik ryzyka [rakotworczy]

84%

Jaskowski J.

Acta Biologica et Medica

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1992

|

tom 18

129-136

3

Zanieczyszczenie gleby przez wielopierscieniowe weglowodory aromatyczne [WWA]

84%

Kluska M.

Bromatologia i Chemia Toksykologiczna

|

2003

|

tom 36

|

nr 3

221-226

4

Pharmacological and dietary factors in prevention of colorectal cancer

84%

Waluga M. , Zorniak M. , Fichna J. , Kukla M. , Hartleb M.

Journal of Physiology and Pharmacology

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2018

|

tom 69

|

nr 3

5

Ilosciowe metody szacowania ryzyka kancerogennego

67%

Szymczak W.

Roczniki Państwowego Zakładu Higieny

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2003

|

tom 54

|

nr Supl.

14-15

6

Akrylamid. Cz.II. Aktywnosc biologiczna i metody analizy

67%

Szumska M. , Janoszka B. , Bodzek D.

Bromatologia i Chemia Toksykologiczna

|

2004

|

tom 37

|

nr 1

43-51

7

Metoda oznaczania aktywnosci mutagennej substancji smolowych zawartych w pylach powietrza atmosferycznego

67%

Krogulski A. , Borkowska M.

Roczniki Państwowego Zakładu Higieny

|

1996

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tom 47

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nr 2

175-180

PL

W pracy przedstawiono metodą oznaczania aktywności mutagennej ekstraktu cykloheksanowego pyłów powietrza atmosferycznego. Użyto zmodyfikowanego testu somatycznej mutacji i re-kombinacji u muszki owocowej (SMART)

EN

For assessing of the environmental contamination with potentially carcinogenic mutagens the possibility of the measurement of the mutagenic activity of the substances absorbed on dust suspended in air would be important. These substances include at least several hundreds of organic compounds. Only a small part of them have been studied in detail, and, on the other hand, it is known that at least a score of them are carcinogenic. Additionally, the prescence of some of them can change significantly the action of other ones. Because of that, the effects of a mixture of these substances should be studied as a whole. The fact that the discussed contaminants are present in the air and can be transported over great distances causes that they are dangerous to man both directly (when inhaled) and trough contamination of water, soil and food. Paraleli use in the described method of two cross-bred strains of fruit flies made possible separate assessment of the activity of mutagens and promutangens requiring activation in presence of cytochrome P 450. The use of the eukaryotic organism in which mutations are observed in many cells in one individual (about 2500) enables reliable data to be obtained about the degree of human health risk.

8

Soja a rak piersi

67%

Klys W.

Biuletyn Informacyjny Instytutu Żywności i Żywienia

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1994

|

tom 03

|

nr 1

13-14

9

Metylacja DNA - alternatywny mechanizm chemicznej kancerogenezy

67%

Kostka G. , Urbanek K.

|

2005

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tom 56

|

nr 1

1-14

PL

Na podstawie piśmiennictwa omówiono podstawy epigenetycznych zmian metylacji DNA, jako alternatywnego mechanizmu transformacji nowotworowej komórki Przedstawiono rolą metylacji DNA w regulacji ekspresji genów w aspekcie rakotwórczego działania związków chemicznych nie wywołujących bezpośrednich uszkodzeń DNA.

EN

It is increasingly accepted that the initiation of chemical carcinogenesis should be considered as a transformation process of a normal cell caused by genetic changes, i.e. mutational DNA damage and/or epigenetic changes, which render normal gene expression impossible with the preservation of the DNA sequence intact. Epigenetic DNA methylation changes have been among the most extensively investigated processes in the recent years. Many types of cancer cells have been found to exhibit an increased or reduced level of CpG sequence methylation in promoter regions of genes, especially the genes whose protein products take part in the control of cell cycle regulation. In view of the fact that DNA methylation is thought to play a role in gene expression, its abnormal level in the genes that encode proteins participating in the control of the cell cycle and apoptosis regulation may disturb cell homeostasis resulting in pathologies that may, in turn, lead to neoplastic transformation. Although changes in the mechanisms of transcriptional activity caused by methylation of cytosine in CpG sequences have not been completely elucidated, it has been determined that this relationship is associated with a decreased level of histone acetylation, which induced a more densely-packaged chromatin structures in the methylated regions of chromosomal DNA. A large proportion of chemical carcinogens consists of chemicals whose carcinogenic activity is not related to direct damage of the genetic material. The changes in DNA methylation are being considered as one mechanism of action for non-genotoxic carcinogens (NGCs). The significance of nongenotoxic agents in the development of the carcinogenesis rocess indicate that their mechanisms of the action should be investigated in terms of health hazards they pose to humans exposed to this type of environmental pollutants.

10

Wplyw wybranych polifenoli na proces utleniania bialek w watrobach szczurow z nowotworami indukowanymi DMBA

59%

Tokarz A. , Bobrowska B. , Grynkiewicz G. , Matysiak M.

Bromatologia i Chemia Toksykologiczna

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2007

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tom 40

|

nr 2

187-194

PL

W pracy określono zależność między stosowaną dietą, zróżnicowaną pod względem zawartości polifenoli (ich dawki i rozpuszczalnika, w którym związki były podawane), a procesem peroksydacji białek. Stosownym biowskaźnikiem oksydacyjnych uszkodzeń białek były grupy karbonylowe aminokwasów. W badaniach określono stopień powstawania związków karbonylowych jako skutek równoczesnego działania czynnika kancerogennego 9,10-dimetylobenzantracenu (DMBA). W wyniku przeprowadzonych badań stwierdzono, że obecność związków polifenolowych w diecie może decydować o intensywności przebiegu procesów oksydacyjnych w organizmie.

EN

The aim of the present study was to assess the effect of diets with various content of polyphenols (polyphenol dose and solvent type) upon protein peroxidation. Aminoacid carboxyl groups were used as the biomarkers of the protein oxidative damage. The formation of carbonyl compounds was assessed as an effect of the simultaneous activity of a carcinogen, 9,10-dimethylbenzene anthracene (DMBA). Livers of 20-week Spraque-Dawley female rats killed by decapitation were used as the test material. Our results demonstrate that the polyphenol compounds in the diet may critically affect the intensity of the oxidative processes taking place in the system. The polyphenols (genistein, quercetin, resveratrol) acted to inhibit DMBA-induced formation of oxidated proteins; on the other hand, when DMBA was not present, the process of carbonyl group formation was more intense. The fats contained in the diet show a synergistic effect with the DMBA carcinogen to stimulate the process of aminoacid oxidation.

11

Ryzyko skutkow zdrowotnych zwiazanych z narazeniem srodowiskowym na wielopierscieniowe weglowodory aromatyczne [WWA]

59%

Jakubowski M.

Roczniki Państwowego Zakładu Higieny

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2003

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tom 54

|

nr Supl.

29

12

Prekursory karbaminianu etylu w napojach alkoholowych

59%

Balcerek M.

Przemysł Fermentacyjny i Owocowo-Warzywny

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2006

|

tom 50

|

nr 05

23-26

EN

In this paper the physical and chemical characterization of ethyl carbamate and its occurrence in alcoholic beverages were described. Actual knowledge with specific objectives of the studies were reviewed.

PL

W artykule przedstawiono fizykochemiczną charakterystykę karbaminianu etylu oraz jego występowanie w napojach alkoholowych. Dokonano przeglądu literatury dotyczącej prekursorów uretanu oraz sposobów ograniczania jego zawartości.

13

Heterocykliczne aromatyczne aminy w zywnosci: zawartosc aminoazaarenow w wysokobialkowej zywnosci oraz szacunkowe narazenie czlowieka na te zwiazki

59%

Janoszka B.

Bromatologia i Chemia Toksykologiczna

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2006

|

tom 39

|

nr 4

345-352

14

Heterocykliczne aminy aromatyczne w zywnosci: wplyw antyoksydantow i dodatkow pochodzenia roslinnego na stezenie aminoazaarenow w zywnosci wysokobialkowej

59%

Janoszka B.

Bromatologia i Chemia Toksykologiczna

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2006

|

tom 39

|

nr 4

353-360

15

Stezenia insektycydow chloroorganicznych w tkance tluszczowej gruczolu piersiowego kobiet w Polsce w latach 1997-2001

59%

Strucinski P. , Ludwicki J. K. , Goralczyk K. , Czaja K. , Olszewski W. , Jethon J. , Baranska J. , Hernik A.

Roczniki Państwowego Zakładu Higieny

|

2002

|

tom 53

|

nr 3

221-230

PL

Oznaczono stężenia wybranych insektycydów chloroorganicznych: α-, ß-, у- i δ -HCH, izomerów і metabolitów p, p'-DDT, oxy-chlordanu i heptachloru w wycinkach tkanki tłuszczowej pobranych z gruczołu piersiowego 67 kobiet w wieku od 15 do 74 lat. We wszystkich próbkach stwierdzono obecność ß-HCH, p,p'-DDE oraz p, p'-DDT. Stężenia pozostałych związków, wykrywanych w mniejszym odsetku próbek, były w większości przypadków zbliżone do odpowiednich granic oznaczalności. Stała obecność niektórych związków chloroorganicznych w tkance tłuszczowej sutka kobiet budzi uzasadnione obawy, zwłaszcza w świetle doniesień o roli tych substancji jako czynników zwiększających ryzyko zachorowania na raka sutka.

EN

Although manufacture and use of chlorinated insecticides was banned or severely restricted in most of countries in the 1970s, the residues of these compounds are still detected in various environmental matrices all over the world. Their highest levels are found in adipose tissue of beings at the top of food chain, including humans. Levels of persistent organochlorine compounds in human specimens are monitored by numerous scientific organizations in various countries, including Poland. The рurpose of the study was to survey the current levels of selected organochlorine insecticides (isomers α-, ß-, y-, δ-HCH, о,p'- and p,p'-DDT, DDE і DDE, oxy-chlordane and heptachlor) in women's breast adipose tissue which can be an indicator of body burden. A total of 67 samples of adipose breast tissue collected between 1997 and 2001 from non-cancer patients, aged from 15 to 74 years have been analyzed. The analytical procedure included extraction, clean-up and analysis by means of GC-ECD with GC-MS confirmation. In all the samples analyzed p,p'-DDE, p,p'-DDT and ß-HCH were present (mean values, expressed as mg/kg of fat: 0.7700, 0.0720, and 0.0635 respectively) with p,p'-DDE, found to be dominant analyte. The levels of the remaining compounds, were usually about or below the method quantification limits (from 0.0025 to 0.0060 mg/kg of fat). The results for DDTs and ß-HCH for the oldest group (above 50 years) were 2.1 to 3.6 times higher than the youngest group (below 39 years). The results obtained in this study are similar to those reported in analogous samples collected from women living in other European countries with similar climate and history or organochlorines usage as well as in the USA. The presence of some organochlorine insecticide residues in women's adipose tissue, even those, who were born even 10-15 years after most countries introduced severe restrictions or banned the use of these compounds may be cause for anxiety. That is due to the potential of these compounds to promote toxic effects, including disrupting the human endocrine system.

16

Toksykokinetyka i metabolizm O-anizydyny w ustroju szczura

59%

Sapota A. , Czerski B.

Roczniki Państwowego Zakładu Higieny

|

2003

|

tom 54

|

nr Supl.

32-33

17

Ocena metody oznaczania aflatoksyn w orzechach arachidowych przy uzyciu chromatografii powinowactwa immunologicznego z detekcja fluorymetryczna

59%

Postupolski J. , Jankowska B. , Urbanek-Karlowska B.

Roczniki Państwowego Zakładu Higieny

|

1996

|

tom 47

|

nr 3

277-283

PL

W pracy przedstawiono ocenę metody chromatografii powinowactwa immunologicznego do oznaczania sumy aflatoksyn w orzechach arachidowych z wykorzystaniem testu AFLATEST firmy Vicám. Wyznaczono parametry analityczne metody: odzysk, precyzję i dokładność. Metoda ta może być stosowana do półilościowego oznaczania aflatoksyn w rutynowej kontroli żywności.

EN

The aim of the study was determination of the basic analytical parameters of the AFLATEST method (accuracy, precision, recovery) and testing of its usefulness in concentrations down to 10 µ/kg. In the test the studied extracts are purified passing them through columns with monoclonal antibodies, followed by fluorimetric determination after reaction with bromine solution. The capacity and the efficiency of the columns were tested and fluorimeter calibration was checked. The reliability of the method was assessed fortifying a series of arachids samples with aflatoxin Bi and determining then recovery and precision. The accuracy of the method was checked by determination of certified reference standard. In the light of the obtained results the AFLATEST method was found to be applicable for semiquantitative determination of aflatoxins in arachids in the concentrations above 5 µ/kg.

18

Porownanie zawartosci N-nitrozodimetyloaminy w wybranych produktach miesnych

51%

Ciemniak A.

Roczniki Państwowego Zakładu Higieny

|

2006

|

tom 57

|

nr 4

341-346

PL

Przeprowadzono badania wybranych produktów mięsnych pod kątem zawartości w nich N—nitrozodimetyloaminy. Analizy wykonano techniką chromatografii gazowej sprzężonej ze spektrometria mas (GC-MS). Najwyższe zawartości N-nitrozodimetyloaminy stwierdzono w produktach peklowanych i wędzonych.

EN

Nitrosamines are know as the most potent group of carcinogens. Approximately 300of these compounds have been tested, and about 90% of them have been found to be carcinogenic in laboratory animals. N-nitrosodimethylamine causes liver cancer, whereas some of tobacco specific nitrosamines causes lung cancer. Volatile N-nitrosamines induce tumors in a variety of human organs, including the tongue, esophagus, lung, pancreas, liver, kidney and bladder. They are formed during reaction of secondary or tertiary amino compounds and nitrite or nitrogen oxides. Nitrosamines occurs as contaminants in many foodstuff including food and beverages: beers, cheeses, sausages, smoked and pickled foods. They are formed during frying, smoking and food preserved with pickling salt. These compounds can also be produced in man and other mammals under the acidic conditions in the stomach. The present study was carried out to determine level of N-nitrosodimethylamine in selected 13 meat products. The extraction procedure was based on Raoul's method, ie. on two consecutive extraction-concentration step using extrelut and florisil columns. The level of N-nitrosodimethylamine was varied from 0,049 mg/kg to 16,47 mg/kg. The highest level of NDMA was found in smoked sausage.

19

Ocena narazenia dzieci na wielopierscieniowe weglowodory aromatyczne zawarte w glebie placow zabaw w Beskidach

51%

Lukasik K. , Dziewiecka B. , Kulka E.

Roczniki Państwowego Zakładu Higieny

|

2003

|

tom 54

|

nr Supl.

66-67

20

Zastosowanie biomarkerow w ocenie ryzyka zdrowotnego zwiazanego z narazeniem na srodowiskowe chemiczne kancerogeny

51%

Kostka G.

Roczniki Państwowego Zakładu Higieny

|

2003

|

tom 54

|

nr Supl.

30-31