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Detecting and determining carazolol residues in biological samples

100%

Posyniak A. , Semeniuk S. , Niedzielska J. , Zmudzki J.

nr 4

A simple and rapid method is described which allows analysis of Carazolol (ß-blocker agent) in tissue of pig by thin layer and liquid chromatography. The method utilizes an octadecyl solid phase column that selectively absorbs this drug and significantly improves sample clean-up procedure. The compound is eluted from the column with acidic acetonitrile. Analysis is performed using TLC for detection and qualitative determination and isocratic reversed-phase LC for confirmation and quantitation. The detection limit was 10 ng g-1 (TLC) and 2 ng g-1 (LC). The recoveries of Carazolol from spiked samples were above 80%. The procedure is suitable for routine residue analysis.

Screening procedure for simultaneous determination of azaperone, carazolol, and chlorpromazine in animal urine

84%

Sell B. , Posyniak A. , Grylik M.

2011

tom 55

nr 3

A liquid chromatographic method coupled with UV-Vis and fluorescence detectors for the determination of azaperone, carazolol, and chlorpromazine residues in urine has been described. Analytes were isolated from biological samples with acetonitrvle. The obtained extracts were applied to solid phase extraction Strata X-C 33 µn Polimeric Strong Cation columns. The analytes were eluted with alkalised acetonitrvle. The whole procedure was validated according to European Decision 657/2002/EC. The detection limits were established at the level 2 µg/L for Carazolol and 5 µg/L for azaperone and chlorpromazine. Detection capabilities for carazolol, azaperone, and chlorpromazine were 8.62, 18.9, and 6.53 µg/L, respectively. Recoveries were above 90%.